Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 05:49, 4 November 2007 (UTC)[edit]
Proteins without matches (14)[edit]
Proteins with a High Potential Match (12)[edit]
Redirected Proteins (1)[edit]
Created (9)[edit]
Manual Inspection (Page not found) (17)[edit]
Updated (1)[edit]
Protein Status Grid - Date: 05:49, 4 November 2007 (UTC)[edit]
Vebose Log - Date: 05:49, 4 November 2007 (UTC)[edit]
- INFO: Beginning work on ANXA2... {November 3, 2007 4:16:53 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein ANXA2 image.jpg {November 3, 2007 4:18:33 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:18:58 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ANXA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1w7b.
| PDB = {{PDB2|1w7b}}, {{PDB2|1xjl}}, {{PDB2|2hyu}}, {{PDB2|2hyv}}, {{PDB2|2hyw}}
| Name = Annexin A2
| HGNCid = 537
| Symbol = ANXA2
| AltSymbols =; ANX2; ANX2L4; CAL1H; LIP2; LPC2; LPC2D; P36; PAP-IV
| OMIM = 151740
| ECnumber =
| Homologene = 20857
| MGIid = 88246
| GeneAtlas_image1 = PBB_GE_ANXA2_201590_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_ANXA2_208816_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ANXA2_210427_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004859 |text = phospholipase inhibitor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005544 |text = calcium-dependent phospholipid binding}} {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 302
| Hs_Ensembl = ENSG00000182718
| Hs_RefseqProtein = NP_001002857
| Hs_RefseqmRNA = NM_001002857
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 58426643
| Hs_GenLoc_end = 58477477
| Hs_Uniprot = P07355
| Mm_EntrezGene = 12306
| Mm_Ensembl = ENSMUSG00000032231
| Mm_RefseqmRNA = XM_622573
| Mm_RefseqProtein = XP_622573
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 69252847
| Mm_GenLoc_end = 69290959
| Mm_Uniprot = Q3UCD3
}}
}}
'''Annexin A2''', also known as '''ANXA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ANXA2 annexin A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=302| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kwon M, MacLeod TJ, Zhang Y, Waisman DM |title=S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. |journal=Front. Biosci. |volume=10 |issue= |pages= 300-25 |year= 2006 |pmid= 15574370 |doi= }}
*{{cite journal | author=Babiychuk EB, Draeger A |title=Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement? |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 374-6 |year= 2006 |pmid= 16709165 |doi= 10.1042/BST0340374 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BIRC4... {November 3, 2007 4:18:59 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein BIRC4 image.jpg {November 3, 2007 4:20:08 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:20:28 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BIRC4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c9q.
| PDB = {{PDB2|1c9q}}, {{PDB2|1f9x}}, {{PDB2|1g3f}}, {{PDB2|1g73}}, {{PDB2|1i3o}}, {{PDB2|1i4o}}, {{PDB2|1i51}}, {{PDB2|1kmc}}, {{PDB2|1nw9}}, {{PDB2|1tfq}}, {{PDB2|1tft}}, {{PDB2|2opy}}, {{PDB2|2opz}}
| Name = Baculoviral IAP repeat-containing 4
| HGNCid = 592
| Symbol = BIRC4
| AltSymbols =; API3; ILP1; MIHA; XIAP; XLP2
| OMIM = 300079
| ECnumber =
| Homologene = 901
| MGIid = 107572
| GeneAtlas_image1 = PBB_GE_BIRC4_206536_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BIRC4_206537_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043027 |text = caspase inhibitor activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 331
| Hs_Ensembl = ENSG00000101966
| Hs_RefseqProtein = NP_001158
| Hs_RefseqmRNA = NM_001167
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 122821558
| Hs_GenLoc_end = 122875510
| Hs_Uniprot = P98170
| Mm_EntrezGene = 11798
| Mm_Ensembl = ENSMUSG00000025860
| Mm_RefseqmRNA = NM_009688
| Mm_RefseqProtein = NP_033818
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 38315952
| Mm_GenLoc_end = 38350134
| Mm_Uniprot = Q60989
}}
}}
'''Baculoviral IAP repeat-containing 4''', also known as '''BIRC4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.<ref>{{cite web | title = Entrez Gene: BIRC4 baculoviral IAP repeat-containing 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=331| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lacasse EC, Kandimalla ER, Winocour P, ''et al.'' |title=Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640. |journal=Ann. N. Y. Acad. Sci. |volume=1058 |issue= |pages= 215-34 |year= 2006 |pmid= 16394139 |doi= 10.1196/annals.1359.032 }}
*{{cite journal | author=Eckelman BP, Salvesen GS, Scott FL |title=Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. |journal=EMBO Rep. |volume=7 |issue= 10 |pages= 988-94 |year= 2006 |pmid= 17016456 |doi= 10.1038/sj.embor.7400795 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCNE1... {November 3, 2007 4:20:28 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCNE1 image.jpg {November 3, 2007 4:21:04 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:21:17 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCNE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1w98.
| PDB = {{PDB2|1w98}}
| Name = Cyclin E1
| HGNCid = 1589
| Symbol = CCNE1
| AltSymbols =; CCNE
| OMIM = 123837
| ECnumber =
| Homologene = 14452
| MGIid = 88316
| GeneAtlas_image1 = PBB_GE_CCNE1_213523_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016538 |text = cyclin-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000307 |text = cyclin-dependent protein kinase holoenzyme complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006270 |text = DNA replication initiation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 898
| Hs_Ensembl = ENSG00000105173
| Hs_RefseqProtein = NP_001229
| Hs_RefseqmRNA = NM_001238
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 34994741
| Hs_GenLoc_end = 35007056
| Hs_Uniprot = P24864
| Mm_EntrezGene = 12447
| Mm_Ensembl = ENSMUSG00000002068
| Mm_RefseqmRNA = NM_007633
| Mm_RefseqProtein = NP_031659
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 37806746
| Mm_GenLoc_end = 37816294
| Mm_Uniprot = A0JLN2
}}
}}
'''Cyclin E1''', also known as '''CCNE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.<ref>{{cite web | title = Entrez Gene: CCNE1 cyclin E1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=898| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Akita H |title=[Prognostic importance of altered expression of cell cycle regulators in lung cancer] |journal=Nippon Rinsho |volume=60 Suppl 5 |issue= |pages= 267-71 |year= 2003 |pmid= 12101670 |doi= }}
*{{cite journal | author=Mazumder S, DuPree EL, Almasan A |title=A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. |journal=Current cancer drug targets |volume=4 |issue= 1 |pages= 65-75 |year= 2004 |pmid= 14965268 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD209... {November 3, 2007 10:46:47 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD209 image.jpg {November 3, 2007 10:47:55 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 10:48:16 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD209_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k9i.
| PDB = {{PDB2|1k9i}}, {{PDB2|1sl4}}, {{PDB2|1sl5}}, {{PDB2|2b6b}}, {{PDB2|2it5}}, {{PDB2|2it6}}
| Name = CD209 molecule
| HGNCid = 1641
| Symbol = CD209
| AltSymbols =; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; MGC129965
| OMIM = 604672
| ECnumber =
| Homologene = 64372
| MGIid = 2157942
| GeneAtlas_image1 = PBB_GE_CD209_207277_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD209_207278_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005537 |text = mannose binding}} {{GNF_GO|id=GO:0042607 |text = exogenous peptide antigen binding}} {{GNF_GO|id=GO:0046790 |text = virion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007159 |text = leukocyte adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0009988 |text = cell-cell recognition}} {{GNF_GO|id=GO:0019048 |text = virus-host interaction}} {{GNF_GO|id=GO:0019062 |text = virion attachment to host cell surface receptor}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0046795 |text = intracellular virion transport}} {{GNF_GO|id=GO:0046800 |text = enhancement of virulence}} {{GNF_GO|id=GO:0046968 |text = peptide antigen transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 30835
| Hs_Ensembl = ENSG00000090659
| Hs_RefseqProtein = NP_066978
| Hs_RefseqmRNA = NM_021155
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 7710882
| Hs_GenLoc_end = 7718406
| Hs_Uniprot = Q9NNX6
| Mm_EntrezGene = 170786
| Mm_Ensembl = ENSMUSG00000031494
| Mm_RefseqmRNA = NM_133238
| Mm_RefseqProtein = NP_573501
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 3743395
| Mm_GenLoc_end = 3748984
| Mm_Uniprot = Q2TA59
}}
}}
'''CD209 molecule''', also known as '''CD209''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The phylogenetically ancient innate immune system governs the initial detection of pathogens and stimulates the first line of host defense. Recognition of pathogens is mediated by phagocytic cells through germline-encoded receptors, known as 'pattern recognition receptors,' which detect pathogen-associated molecular patterns that are characteristic products of microbial physiology. This initial interaction is then translated into a set of endogenous signals that ultimately lead to the induction of the adaptive immune response. The C-type lectin receptors are involved in the primary interface between host and pathogens. Two prototypic members of the C-type lectin-receptor family act as both cell-adhesion receptors and pathogen-recognition receptors: CD209 and its close relative CD209L (MIM 605872) (Barreiro et al., 2005).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CD209 CD209 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30835| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Geijtenbeek TB, Engering A, Van Kooyk Y |title=DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. |journal=J. Leukoc. Biol. |volume=71 |issue= 6 |pages= 921-31 |year= 2002 |pmid= 12050176 |doi= }}
*{{cite journal | author=Baribaud F, Doms RW, Pöhlmann S |title=The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? |journal=Expert Opin. Ther. Targets |volume=6 |issue= 4 |pages= 423-31 |year= 2006 |pmid= 12223058 |doi= 10.1517/14728222.6.4.423 }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
*{{cite journal | author=van Kooyk Y, Geijtenbeek TB |title=DC-SIGN: escape mechanism for pathogens. |journal=Nat. Rev. Immunol. |volume=3 |issue= 9 |pages= 697-709 |year= 2003 |pmid= 12949494 |doi= 10.1038/nri1182 }}
*{{cite journal | author=Turville S, Wilkinson J, Cameron P, ''et al.'' |title=The role of dendritic cell C-type lectin receptors in HIV pathogenesis. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 710-8 |year= 2004 |pmid= 12960229 |doi= 10.1189/jlb.0503208 }}
*{{cite journal | author=Cambi A, Figdor CG |title=Dual function of C-type lectin-like receptors in the immune system. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 5 |pages= 539-46 |year= 2004 |pmid= 14519388 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD36... {November 3, 2007 4:21:17 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:22:01 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD36 molecule (thrombospondin receptor)
| HGNCid = 1663
| Symbol = CD36
| AltSymbols =; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
| OMIM = 173510
| ECnumber =
| Homologene = 73871
| MGIid = 107899
| GeneAtlas_image1 = PBB_GE_CD36_206488_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 948
| Hs_Ensembl = ENSG00000135218
| Hs_RefseqProtein = NP_000063
| Hs_RefseqmRNA = NM_000072
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 80069459
| Hs_GenLoc_end = 80141668
| Hs_Uniprot = P16671
| Mm_EntrezGene = 12491
| Mm_Ensembl = ENSMUSG00000002944
| Mm_RefseqmRNA = NM_007643
| Mm_RefseqProtein = NP_031669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 17297546
| Mm_GenLoc_end = 17340718
| Mm_Uniprot = Q3TA14
}}
}}
'''CD36 molecule (thrombospondin receptor)''', also known as '''CD36''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.<ref>{{cite web | title = Entrez Gene: CD36 CD36 molecule (thrombospondin receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=948| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Abumrad NA, Ajmal M, Pothakos K, Robinson JK |title=CD36 expression and brain function: does CD36 deficiency impact learning ability? |journal=Prostaglandins Other Lipid Mediat. |volume=77 |issue= 1-4 |pages= 77-83 |year= 2005 |pmid= 16099393 |doi= 10.1016/j.prostaglandins.2004.09.012 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CETP... {November 3, 2007 4:22:01 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 3, 2007 4:22:40 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:22:50 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CETP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2obd.
| PDB = {{PDB2|2obd}}
| Name = Cholesteryl ester transfer protein, plasma
| HGNCid = 1869
| Symbol = CETP
| AltSymbols =;
| OMIM = 118470
| ECnumber =
| Homologene = 47904
| MGIid =
| GeneAtlas_image1 = PBB_GE_CETP_206210_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1071
| Hs_Ensembl = ENSG00000087237
| Hs_RefseqProtein = NP_000069
| Hs_RefseqmRNA = NM_000078
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 55553263
| Hs_GenLoc_end = 55575257
| Hs_Uniprot = P11597
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cholesteryl ester transfer protein, plasma''', also known as '''CETP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cholestery ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect susceptibility to atherosclerosis.<ref>{{cite web | title = Entrez Gene: CETP cholesteryl ester transfer protein, plasma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1071| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Okajima F |title=[Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 480-7 |year= 2002 |pmid= 11915346 |doi= }}
*{{cite journal | author=Barter PJ, Brewer HB, Chapman MJ, ''et al.'' |title=Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 2 |pages= 160-7 |year= 2003 |pmid= 12588754 |doi= }}
*{{cite journal | author=Dallinga-Thie GM, Dullaart RP, van Tol A |title=Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 251-7 |year= 2007 |pmid= 17495597 |doi= 10.1097/MOL.0b013e3280e12685 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FADD... {November 3, 2007 10:45:59 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein FADD image.jpg {November 3, 2007 10:46:33 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 10:46:47 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FADD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a1w.
| PDB = {{PDB2|1a1w}}, {{PDB2|1a1z}}, {{PDB2|1e3y}}, {{PDB2|1e41}}, {{PDB2|2gf5}}
| Name = Fas (TNFRSF6)-associated via death domain
| HGNCid = 3573
| Symbol = FADD
| AltSymbols =; GIG3; MGC8528; MORT1
| OMIM = 602457
| ECnumber =
| Homologene = 2836
| MGIid = 109324
| GeneAtlas_image1 = PBB_GE_FADD_202535_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8772
| Hs_Ensembl = ENSG00000168040
| Hs_RefseqProtein = NP_003815
| Hs_RefseqmRNA = NM_003824
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 69726917
| Hs_GenLoc_end = 69731134
| Hs_Uniprot = Q13158
| Mm_EntrezGene = 14082
| Mm_Ensembl = ENSMUSG00000031077
| Mm_RefseqmRNA = NM_010175
| Mm_RefseqProtein = NP_034305
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 144387713
| Mm_GenLoc_end = 144391826
| Mm_Uniprot = Q8CD57
}}
}}
'''Fas (TNFRSF6)-associated via death domain''', also known as '''FADD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.<ref>{{cite web | title = Entrez Gene: FADD Fas (TNFRSF6)-associated via death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8772| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sheikh MS, Huang Y |title=The FADD is going nuclear. |journal=Cell Cycle |volume=2 |issue= 4 |pages= 346-7 |year= 2004 |pmid= 12851487 |doi= }}
*{{cite journal | author=Bhojani MS, Chen G, Ross BD, ''et al.'' |title=Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1478-81 |year= 2007 |pmid= 16258269 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGG... {November 3, 2007 4:22:50 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein FGG image.jpg {November 3, 2007 4:23:34 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 4:23:42 PM PDT}
- CREATED: Created new protein page: FGG {November 3, 2007 4:23:51 PM PDT}
- INFO: Beginning work on HCG4P11... {November 3, 2007 10:49:01 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 10:49:18 PM PDT}
- CREATED: Created new protein page: HCG4P11 {November 3, 2007 10:49:26 PM PDT}
- INFO: Beginning work on HDAC2... {November 3, 2007 4:23:51 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 4:24:28 PM PDT}
- CREATED: Created new protein page: HDAC2 {November 3, 2007 4:24:37 PM PDT}
- INFO: Beginning work on HMGB1... {November 3, 2007 4:25:48 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein HMGB1 image.jpg {November 3, 2007 4:48:41 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 4:49:00 PM PDT}
- CREATED: Created new protein page: HMGB1 {November 3, 2007 4:49:09 PM PDT}
- INFO: Beginning work on HSPA5... {November 3, 2007 4:49:09 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:49:57 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
| HGNCid = 5238
| Symbol = HSPA5
| AltSymbols =; MIF2; BIP; FLJ26106; GRP78
| OMIM = 138120
| ECnumber =
| Homologene = 3908
| MGIid = 95835
| GeneAtlas_image1 = PBB_GE_HSPA5_211936_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0043022 |text = ribosome binding}} {{GNF_GO|id=GO:0043027 |text = caspase inhibitor activity}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0008303 |text = caspase complex}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0043154 |text = negative regulation of caspase activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3309
| Hs_Ensembl = ENSG00000044574
| Hs_RefseqProtein = NP_005338
| Hs_RefseqmRNA = NM_005347
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 127036953
| Hs_GenLoc_end = 127043430
| Hs_Uniprot = P11021
| Mm_EntrezGene = 14828
| Mm_Ensembl = ENSMUSG00000026864
| Mm_RefseqmRNA = NM_022310
| Mm_RefseqProtein = NP_071705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 34594099
| Mm_GenLoc_end = 34598538
| Mm_Uniprot = Q3TI47
}}
}}
'''Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)''', also known as '''HSPA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3309| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li J, Lee AS |title=Stress induction of GRP78/BiP and its role in cancer. |journal=Curr. Mol. Med. |volume=6 |issue= 1 |pages= 45-54 |year= 2006 |pmid= 16472112 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPB1... {November 3, 2007 4:49:57 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:50:24 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 27kDa protein 1
| HGNCid = 5246
| Symbol = HSPB1
| AltSymbols =; CMT2F; DKFZp586P1322; HS.76067; HSP27; HSP28; Hsp25
| OMIM = 602195
| ECnumber =
| Homologene = 1180
| MGIid = 96240
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0009986 |text = cell surface}}
| Process = {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3315
| Hs_Ensembl = ENSG00000106211
| Hs_RefseqProtein = NP_001531
| Hs_RefseqmRNA = NM_001540
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 75769966
| Hs_GenLoc_end = 75771545
| Hs_Uniprot = P04792
| Mm_EntrezGene = 15507
| Mm_Ensembl = ENSMUSG00000004951
| Mm_RefseqmRNA = NM_013560
| Mm_RefseqProtein = NP_038588
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 136172606
| Mm_GenLoc_end = 136174189
| Mm_Uniprot = Q545F4
}}
}}
'''Heat shock 27kDa protein 1''', also known as '''HSPB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IGFBP1... {November 3, 2007 4:50:24 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein IGFBP1 image.jpg {November 3, 2007 4:58:22 PM PDT}
- SEARCH REDIRECT: Control Box Found: Insulin-like growth factor 1 {November 3, 2007 4:58:45 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 3, 2007 4:58:47 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 3, 2007 4:58:47 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 3, 2007 4:58:47 PM PDT}
- UPDATED: Updated protein page: Insulin-like growth factor 1 {November 3, 2007 4:58:58 PM PDT}
- INFO: Beginning work on ITGA3... {November 3, 2007 4:58:59 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 5:00:00 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
| HGNCid = 6139
| Symbol = ITGA3
| AltSymbols =; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a
| OMIM = 605025
| ECnumber =
| Homologene = 21129
| MGIid = 96602
| GeneAtlas_image1 = PBB_GE_ITGA3_201474_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007613 |text = memory}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3675
| Hs_Ensembl = ENSG00000005884
| Hs_RefseqProtein = NP_002195
| Hs_RefseqmRNA = NM_002204
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 45488431
| Hs_GenLoc_end = 45522843
| Hs_Uniprot = P26006
| Mm_EntrezGene = 16400
| Mm_Ensembl = ENSMUSG00000001507
| Mm_RefseqmRNA = NM_013565
| Mm_RefseqProtein = NP_038593
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 94860566
| Mm_GenLoc_end = 94892891
| Mm_Uniprot = Q5SWB9
}}
}}
'''Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)''', also known as '''ITGA3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').<ref>{{cite web | title = Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3675| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bosman FT |title=Integrins: cell adhesives and modulators of cell function. |journal=Histochem. J. |volume=25 |issue= 7 |pages= 469-77 |year= 1993 |pmid= 8407358 |doi= }}
*{{cite journal | author=Fornaro M, Languino LR |title=Alternatively spliced variants: a new view of the integrin cytoplasmic domain. |journal=Matrix Biol. |volume=16 |issue= 4 |pages= 185-93 |year= 1998 |pmid= 9402008 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITGAM... {November 3, 2007 5:00:00 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein ITGAM image.jpg {November 3, 2007 5:00:39 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 5:01:01 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGAM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bho.
| PDB = {{PDB2|1bho}}, {{PDB2|1bhq}}, {{PDB2|1idn}}, {{PDB2|1ido}}, {{PDB2|1jlm}}, {{PDB2|1m1u}}, {{PDB2|1mf7}}, {{PDB2|1n9z}}, {{PDB2|1na5}}
| Name = Integrin, alpha M (complement component 3 receptor 3 subunit)
| HGNCid = 6149
| Symbol = ITGAM
| AltSymbols =; CD11B; CR3A; MAC-1; MAC1A; MGC117044; MO1A
| OMIM = 120980
| ECnumber =
| Homologene = 526
| MGIid = 96607
| GeneAtlas_image1 = PBB_GE_ITGAM_205786_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0001846 |text = opsonin binding}} {{GNF_GO|id=GO:0001948 |text = glycoprotein binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0030593 |text = neutrophil chemotaxis}} {{GNF_GO|id=GO:0045123 |text = cellular extravasation}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3684
| Hs_Ensembl = ENSG00000169896
| Hs_RefseqProtein = NP_000623
| Hs_RefseqmRNA = NM_000632
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 31180512
| Hs_GenLoc_end = 31251207
| Hs_Uniprot = P11215
| Mm_EntrezGene = 16409
| Mm_Ensembl = ENSMUSG00000030786
| Mm_RefseqmRNA = NM_008401
| Mm_RefseqProtein = NP_032427
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 127853827
| Mm_GenLoc_end = 127918264
| Mm_Uniprot = A1E2I0
}}
}}
'''Integrin, alpha M (complement component 3 receptor 3 subunit)''', also known as '''ITGAM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable<ref>{{cite web | title = Entrez Gene: ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3684| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stewart M, Thiel M, Hogg N |title=Leukocyte integrins. |journal=Curr. Opin. Cell Biol. |volume=7 |issue= 5 |pages= 690-6 |year= 1996 |pmid= 8573344 |doi= }}
*{{cite journal | author=Todd RF, Petty HR |title=Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors. |journal=J. Lab. Clin. Med. |volume=129 |issue= 5 |pages= 492-8 |year= 1997 |pmid= 9142045 |doi= }}
*{{cite journal | author=Schymeinsky J, Mócsai A, Walzog B |title=Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications. |journal=Thromb. Haemost. |volume=98 |issue= 2 |pages= 262-73 |year= 2007 |pmid= 17721605 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MMP7... {November 3, 2007 5:01:02 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein MMP7 image.jpg {November 3, 2007 5:01:51 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 5:02:06 PM PDT}
- CREATED: Created new protein page: MMP7 {November 3, 2007 5:02:22 PM PDT}
- INFO: Beginning work on NAT2... {November 3, 2007 4:15:55 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein NAT2 image.jpg {November 3, 2007 4:16:33 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 4:16:44 PM PDT}
- CREATED: Created new protein page: NAT2 {November 3, 2007 4:16:53 PM PDT}
- INFO: Beginning work on NCOA1... {November 3, 2007 10:44:00 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCOA1 image.jpg {November 3, 2007 10:45:38 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 10:45:59 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCOA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oj5.
| PDB = {{PDB2|1oj5}}, {{PDB2|2c52}}, {{PDB2|2prg}}
| Name = Nuclear receptor coactivator 1
| HGNCid = 7668
| Symbol = NCOA1
| AltSymbols =; SRC1; F-SRC-1; MGC129719; MGC129720; NCoA-1; RIP160
| OMIM = 602691
| ECnumber =
| Homologene = 7859
| MGIid = 1276523
| GeneAtlas_image1 = PBB_GE_NCOA1_209106_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCOA1_209105_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCOA1_209107_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8648
| Hs_Ensembl = ENSG00000084676
| Hs_RefseqProtein = NP_003734
| Hs_RefseqmRNA = NM_003743
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 24660850
| Hs_GenLoc_end = 24847075
| Hs_Uniprot = Q15788
| Mm_EntrezGene = 17977
| Mm_Ensembl = ENSMUSG00000020647
| Mm_RefseqmRNA = XM_001000135
| Mm_RefseqProtein = XP_001000135
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 4257418
| Mm_GenLoc_end = 4491127
| Mm_Uniprot = Q3U3A3
}}
}}
'''Nuclear receptor coactivator 1''', also known as '''NCOA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: NCOA1 nuclear receptor coactivator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8648| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Qi C, Zhu Y, Reddy JK |title=Peroxisome proliferator-activated receptors, coactivators, and downstream targets. |journal=Cell Biochem. Biophys. |volume=32 Spring |issue= |pages= 187-204 |year= 2001 |pmid= 11330046 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NRG1... {November 3, 2007 4:24:37 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein NRG1 image.jpg {November 3, 2007 4:25:14 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:25:48 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NRG1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hae.
| PDB = {{PDB2|1hae}}, {{PDB2|1haf}}, {{PDB2|1hre}}, {{PDB2|1hrf}}
| Name = Neuregulin 1
| HGNCid = 7997
| Symbol = NRG1
| AltSymbols =; ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; NDF; SMDF
| OMIM = 142445
| ECnumber =
| Homologene = 8509
| MGIid = 96083
| GeneAtlas_image1 = PBB_GE_NRG1_206343_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0030297 |text = transmembrane receptor protein tyrosine kinase activator activity}} {{GNF_GO|id=GO:0030971 |text = receptor tyrosine kinase binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3084
| Hs_Ensembl = ENSG00000157168
| Hs_RefseqProtein = NP_004486
| Hs_RefseqmRNA = NM_004495
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 31617043
| Hs_GenLoc_end = 32741608
| Hs_Uniprot = Q15491
| Mm_EntrezGene = 211323
| Mm_Ensembl = ENSMUSG00000062991
| Mm_RefseqmRNA = XM_620642
| Mm_RefseqProtein = XP_620642
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 33283963
| Mm_GenLoc_end = 33475044
| Mm_Uniprot =
}}
}}
'''Neuregulin 1''', also known as '''NRG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.<ref>{{cite web | title = Entrez Gene: NRG1 neuregulin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3084| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lupu R, Lippman ME |title=William L. McGuire Memorial Symposium. The role of erbB2 signal transduction pathways in human breast cancer. |journal=Breast Cancer Res. Treat. |volume=27 |issue= 1-2 |pages= 83-93 |year= 1994 |pmid= 7903175 |doi= }}
*{{cite journal | author=Corfas G, Roy K, Buxbaum JD |title=Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. |journal=Nat. Neurosci. |volume=7 |issue= 6 |pages= 575-80 |year= 2004 |pmid= 15162166 |doi= 10.1038/nn1258 }}
*{{cite journal | author=Harrison PJ, Law AJ |title=Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. |journal=Biol. Psychiatry |volume=60 |issue= 2 |pages= 132-40 |year= 2006 |pmid= 16442083 |doi= 10.1016/j.biopsych.2005.11.002 }}
*{{cite journal | author=Munafò MR, Thiselton DL, Clark TG, Flint J |title=Association of the NRG1 gene and schizophrenia: a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 539-46 |year= 2006 |pmid= 16520822 |doi= 10.1038/sj.mp.4001817 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OGG1... {November 3, 2007 5:02:23 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein OGG1 image.jpg {November 3, 2007 5:04:04 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 5:04:22 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OGG1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ebm.
| PDB = {{PDB2|1ebm}}, {{PDB2|1fn7}}, {{PDB2|1hu0}}, {{PDB2|1ko9}}, {{PDB2|1lwv}}, {{PDB2|1lww}}, {{PDB2|1lwy}}, {{PDB2|1m3h}}, {{PDB2|1m3q}}, {{PDB2|1n39}}, {{PDB2|1n3a}}, {{PDB2|1n3c}}, {{PDB2|1yqk}}, {{PDB2|1yql}}, {{PDB2|1yqm}}, {{PDB2|1yqr}}, {{PDB2|2i5w}}, {{PDB2|2nob}}, {{PDB2|2noe}}, {{PDB2|2nof}}, {{PDB2|2noh}}, {{PDB2|2noi}}, {{PDB2|2nol}}, {{PDB2|2noz}}
| Name = 8-oxoguanine DNA glycosylase
| HGNCid = 8125
| Symbol = OGG1
| AltSymbols =; HMMH; HOGG1; MUTM; OGH1
| OMIM = 601982
| ECnumber =
| Homologene = 1909
| MGIid = 1097693
| GeneAtlas_image1 = PBB_GE_OGG1_205301_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OGG1_205760_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0008534 |text = oxidized purine base lesion DNA N-glycosylase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4968
| Hs_Ensembl = ENSG00000114026
| Hs_RefseqProtein = NP_002533
| Hs_RefseqmRNA = NM_002542
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 9765705
| Hs_GenLoc_end = 9783421
| Hs_Uniprot = O15527
| Mm_EntrezGene = 18294
| Mm_Ensembl = ENSMUSG00000030271
| Mm_RefseqmRNA = NM_010957
| Mm_RefseqProtein = NP_035087
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 113292779
| Mm_GenLoc_end = 113299963
| Mm_Uniprot = Q3UIL3
}}
}}
'''8-oxoguanine DNA glycosylase''', also known as '''OGG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.<ref>{{cite web | title = Entrez Gene: OGG1 8-oxoguanine DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4968| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Boiteux S, Radicella JP |title=The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. |journal=Arch. Biochem. Biophys. |volume=377 |issue= 1 |pages= 1-8 |year= 2000 |pmid= 10775435 |doi= 10.1006/abbi.2000.1773 }}
*{{cite journal | author=Park J, Chen L, Tockman MS, ''et al.'' |title=The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk. |journal=Pharmacogenetics |volume=14 |issue= 2 |pages= 103-9 |year= 2004 |pmid= 15077011 |doi= }}
*{{cite journal | author=Hung RJ, Hall J, Brennan P, Boffetta P |title=Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. |journal=Am. J. Epidemiol. |volume=162 |issue= 10 |pages= 925-42 |year= 2006 |pmid= 16221808 |doi= 10.1093/aje/kwi318 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAN... {November 3, 2007 5:04:23 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 3, 2007 5:08:28 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 5:08:45 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a2k.
| PDB = {{PDB2|1a2k}}, {{PDB2|1byu}}, {{PDB2|1i2m}}, {{PDB2|1ibr}}, {{PDB2|1k5d}}, {{PDB2|1k5g}}, {{PDB2|1qbk}}, {{PDB2|1qg2}}, {{PDB2|1qg4}}, {{PDB2|1rrp}}, {{PDB2|1wa5}}, {{PDB2|2bku}}, {{PDB2|3ran}}
| Name = RAN, member RAS oncogene family
| HGNCid = 9846
| Symbol = RAN
| AltSymbols =; ARA24; Gsp1; TC4
| OMIM = 601179
| ECnumber =
| Homologene = 68143
| MGIid = 1333112
| GeneAtlas_image1 = PBB_GE_RAN_200750_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAN_200749_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000178 |text = exosome (RNase complex)}} {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006405 |text = RNA export from nucleus}} {{GNF_GO|id=GO:0006606 |text = protein import into nucleus}} {{GNF_GO|id=GO:0006611 |text = protein export from nucleus}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007052 |text = mitotic spindle organization and biogenesis}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5901
| Hs_Ensembl = ENSG00000132341
| Hs_RefseqProtein = NP_006316
| Hs_RefseqmRNA = NM_006325
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 129922521
| Hs_GenLoc_end = 129927316
| Hs_Uniprot = P62826
| Mm_EntrezGene = 19384
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009391
| Mm_RefseqProtein = NP_033417
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''RAN, member RAS oncogene family''', also known as '''RAN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.<ref>{{cite web | title = Entrez Gene: RAN RAN, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5901| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138-43 |year= 1998 |pmid= 9562972 |doi= }}
*{{cite journal | author=Budhu AS, Wang XW |title=Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1510-4 |year= 2007 |pmid= 16294017 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RETN... {November 3, 2007 10:48:16 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 10:49:01 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Resistin
| HGNCid = 20389
| Symbol = RETN
| AltSymbols =; ADSF; FIZZ3; MGC126603; MGC126609; RETN1; RSTN; XCP1
| OMIM = 605565
| ECnumber =
| Homologene = 10703
| MGIid = 1888506
| GeneAtlas_image1 = PBB_GE_RETN_220570_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 56729
| Hs_Ensembl = ENSG00000104918
| Hs_RefseqProtein = NP_065148
| Hs_RefseqmRNA = NM_020415
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 7639972
| Hs_GenLoc_end = 7641340
| Hs_Uniprot = Q9HD89
| Mm_EntrezGene = 57264
| Mm_Ensembl = ENSMUSG00000012705
| Mm_RefseqmRNA = NM_022984
| Mm_RefseqProtein = NP_075360
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 3655771
| Mm_GenLoc_end = 3659817
| Mm_Uniprot = Q3V2F6
}}
}}
'''Resistin''', also known as '''RETN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes.<ref>{{cite web | title = Entrez Gene: RETN resistin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56729| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Banerjee RR, Lazar MA |title=Resistin: molecular history and prognosis. |journal=J. Mol. Med. |volume=81 |issue= 4 |pages= 218-26 |year= 2004 |pmid= 12700889 |doi= 10.1007/s00109-003-0428-9 }}
*{{cite journal | author=Motojima K |title=The physiological role of resistin and its connection with metabolic diseases. |journal=J. Endocrinol. Invest. |volume=26 |issue= 12 |pages= 1171-3 |year= 2004 |pmid= 15055467 |doi= }}
*{{cite journal | author=Adeghate E |title=An update on the biology and physiology of resistin. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2485-96 |year= 2004 |pmid= 15526156 |doi= 10.1007/s00018-004-4083-2 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RHO... {November 3, 2007 5:08:45 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein RHO image.jpg {November 3, 2007 10:37:15 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 10:37:33 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RHO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eds.
| PDB = {{PDB2|1eds}}, {{PDB2|1edx}}, {{PDB2|1f88}}, {{PDB2|1gzm}}, {{PDB2|1hzx}}, {{PDB2|1jfp}}, {{PDB2|1l9h}}, {{PDB2|1ln6}}, {{PDB2|1u19}}, {{PDB2|2g87}}, {{PDB2|2hpy}}, {{PDB2|2i35}}, {{PDB2|2i36}}, {{PDB2|2i37}}
| Name = Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)
| HGNCid = 10012
| Symbol = RHO
| AltSymbols =; MGC138309; MGC138311; OPN2; RP4
| OMIM = 180380
| ECnumber =
| Homologene = 68068
| MGIid = 97914
| GeneAtlas_image1 = PBB_GE_RHO_206454_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RHO_206455_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0001750 |text = photoreceptor outer segment}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007603 |text = phototransduction, visible light}} {{GNF_GO|id=GO:0016056 |text = rhodopsin mediated signaling}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6010
| Hs_Ensembl = ENSG00000163914
| Hs_RefseqProtein = NP_000530
| Hs_RefseqmRNA = NM_000539
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 130730172
| Hs_GenLoc_end = 130736867
| Hs_Uniprot = P08100
| Mm_EntrezGene = 212541
| Mm_Ensembl = ENSMUSG00000030324
| Mm_RefseqmRNA = NM_145383
| Mm_RefseqProtein = NP_663358
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 115897546
| Mm_GenLoc_end = 115904449
| Mm_Uniprot = Q8K0D8
}}
}}
'''Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)''', also known as '''RHO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.<ref>{{cite web | title = Entrez Gene: RHO rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6010| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Humphries P, Kenna P, Farrar GJ |title=On the molecular genetics of retinitis pigmentosa. |journal=Science |volume=256 |issue= 5058 |pages= 804-8 |year= 1992 |pmid= 1589761 |doi= }}
*{{cite journal | author=Edwards SC |title=Involvement of cGMP and calcium in the photoresponse in vertebrate photoreceptor cells. |journal=The Journal of the Florida Medical Association |volume=82 |issue= 7 |pages= 485-8 |year= 1995 |pmid= 7673885 |doi= }}
*{{cite journal | author=al-Maghtheh M, Gregory C, Inglehearn C, ''et al.'' |title=Rhodopsin mutations in autosomal dominant retinitis pigmentosa. |journal=Hum. Mutat. |volume=2 |issue= 4 |pages= 249-55 |year= 1993 |pmid= 8401533 |doi= 10.1002/humu.1380020403 }}
*{{cite journal | author=Garriga P, Manyosa J |title=The eye photoreceptor protein rhodopsin. Structural implications for retinal disease. |journal=FEBS Lett. |volume=528 |issue= 1-3 |pages= 17-22 |year= 2002 |pmid= 12297272 |doi= }}
*{{cite journal | author=Mendes HF, van der Spuy J, Chapple JP, Cheetham ME |title=Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy. |journal=Trends in molecular medicine |volume=11 |issue= 4 |pages= 177-85 |year= 2005 |pmid= 15823756 |doi= 10.1016/j.molmed.2005.02.007 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SKP2... {November 3, 2007 10:37:34 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein SKP2 image.jpg {November 3, 2007 10:39:27 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 10:39:47 PM PDT}
- CREATED: Created new protein page: SKP2 {November 3, 2007 10:39:56 PM PDT}
- INFO: Beginning work on TCF3... {November 3, 2007 10:39:56 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 10:43:00 PM PDT}
- CREATED: Created new protein page: TCF3 {November 3, 2007 10:43:09 PM PDT}
- INFO: Beginning work on ZNF35... {November 3, 2007 10:43:09 PM PDT}
- CREATE: Found no pages, creating new page. {November 3, 2007 10:43:48 PM PDT}
- CREATED: Created new protein page: ZNF35 {November 3, 2007 10:44:00 PM PDT}
end log.
