User:Mr. Ibrahem/Papaverine
Clinical data | |
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Pronunciation | /pəˈpævəriːn/ |
Trade names | Pavabid, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682707 |
Pregnancy category |
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Routes of administration | By mouth, intravenous, intramuscular, rectal, intracavernosal |
Drug class | Vasodilator[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 80% |
Protein binding | ~90% |
Metabolism | Liver |
Elimination half-life | 1.5–2 hours |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C20H21NO4 |
Molar mass | 339.391 g·mol−1 |
3D model (JSmol) | |
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Papaverine is a medication primarily used to treat arterial spasm and erectile dysfunction (ED).[1] It is not a first line agent for ED.[1] Other uses have include painful periods and gastrointestinal spasms.[1] It is given by mouth or by injection.[1] Onset is relatively rapid and lasts for hours.[1]
Common side effects include nausea, constipation, headache, abdominal pain, flushing, low blood pressure, and priapism.[1] Other side effects may include respiratory arrest, liver problems, abuse, and arrhythmia.[1] Safety in pregnancy is unclear.[2]
Papaverine was first isolated in 1848 from opium.[3] Despite being from opium it contains no opioid activity.[4] In the United States a 60 mg dose costs about 40 USD as of 2021.[5]
References[edit]
- ^ a b c d e f g h i j "Papaverine Monograph for Professionals". Drugs.com. Archived from the original on 8 June 2021. Retrieved 26 October 2021.
- ^ "DailyMed - PAPAVERINE HYDROCHLORIDE injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
- ^ Hanessian, Stephen (18 December 2013). Natural Products in Medicinal Chemistry. John Wiley & Sons. p. 227. ISBN 978-3-527-67655-2. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
- ^ Sdrales, Lorraine M.; Miller, Ronald D. (21 May 2012). Miller's Anesthesia Review: Expert Consult - Online and Print. Elsevier Health Sciences. p. 66. ISBN 978-1-4377-2793-7. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
- ^ "Papaverine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 31 July 2020. Retrieved 26 October 2021.