User:Mr. Ibrahem/Nalmefene
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| Clinical data | |
|---|---|
| Pronunciation | nal’ me feen |
| Trade names | Selincro, Revex, others |
| Other names | Nalmetrene |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a605043 |
| License data | |
| Routes of administration | By mouth, intravenous |
| Drug class | Opioid antagonist.[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 45% |
| Metabolism | Liver |
| Elimination half-life | 10.8 ± 5.2 hours |
| Excretion | Kidney |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C21H25NO3 |
| Molar mass | 339.435 g·mol−1 |
| 3D model (JSmol) | |
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Nalmefene, sold under the brand name Selincro among others, is a medication used to treat opioid overdose and alcohol dependence.[1][2] Other uses may include pathological gambling.[3] It is taken by mouth or by injection.[1][2]
Common side effects include nausea, fast heart rate, and high blood pressure.[1] Other side effects may include arrhythmias, seizures, and opioid withdrawal.[1] While there is no evidence of harm in pregnancy, such use has not been well studied.[4] It is an opioid antagonist.[1]
Nalmefene was approved for medical use in the United States in 1995.[1] In the United Kingdom 4 weeks at a dose of 18 mg per day costs the NHS about £85.[2] It was discontinued commercially in the United States in 2008.[5]
References[edit]
- ^ a b c d e f g h i "Nalmefene Monograph for Professionals". Drugs.com. Archived from the original on 8 August 2021. Retrieved 11 November 2021.
- ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 518. ISBN 978-0857114105.
- ^ "Nalmefene". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 11 November 2021.
- ^ "Nalmefene (Revex) Use During Pregnancy". Drugs.com. Archived from the original on 8 August 2021. Retrieved 11 November 2021.
- ^ "Baxter discontinues Revex injection". Monthly Prescribing Reference website. Haymarket Media, Inc. 9 July 2008. Archived from the original on 11 October 2016. Retrieved 10 October 2016.