User:Mr. Ibrahem/Dalteparin
 | |
| Clinical data | |
|---|---|
| Trade names | Fragmin |
| Other names | Dalteparin sodium |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
|
| Routes of administration | Subcutaneous |
| Drug class | Low molecular weight heparin (LMWH)[2] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 81-93% |
| Elimination half-life | 3-5 hours subcutaneous; 2.1-2.3 hours IV |
| Excretion | Kidney |
Dalteparin, sold under the brand name Fragmin, is a medication used to treat and prevent deep vein thrombosis and pulmonary embolism.[2] It may also be used in heart attacks.[2] It is given by injection under the skin.[2]
Common side effects include bleeding, low platelets, and bruising at the site of injection.[2] It may be used in pregnancy.[2] It is a low molecular weight heparin (LMWH).[2] It acts by binding to antithrombin III and inhibiting activation of Factor IX and thrombin.[3]
Dalteparin was approved for medical use in the United States in 1994.[2] It is on the World Health Organization's List of Essential Medicines as an alternative to enoxaparin.[4] In the United Kingdom a dose of 5,000 units costs the NHS about £2.80 as of 2021.[5] In the United States this amount costs about 40 USD.[6]
References[edit]
- ^ a b "Dalteparin (Fragmin) Use During Pregnancy". Drugs.com. 27 November 2019. Archived from the original on 3 July 2020. Retrieved 1 June 2020.
- ^ a b c d e f g h i j "Dalteparin Monograph for Professionals". Drugs.com. Archived from the original on 14 April 2021. Retrieved 17 December 2021.
- ^ "Low Molecular Weight Heparins". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 17 December 2021.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 144. ISBN 978-0857114105.
- ^ "Fragmin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 December 2021.