Talk:CpG island

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Untitled[edit]

Going to expand this article sometime soon - watch this space. Viridae ^Talk 12:55, 27 June 2006 (UTC)[reply]

Is the "p" really necessary?[edit]

What other kind of bond (other than a phosphodiester bond) would exist between two nucleotides on the same strand within a natually occuring genome? Why not just CG island? The "p" seems redundant and even suggestive of an additional phosphorylation modification.

Yea it confused me too till I read CpG site which says it differentiates between G:C basepairing. It's just a name though. Aaadddaaammm 01:02, 5 November 2006 (UTC)[reply]

Should consider adding CG Island to link to this article. Google searching CG Island was not getting me anywhere, but this is obviously what I was looking for. 136.165.191.251 (talk) 20:52, 27 June 2008 (UTC)[reply]

This is what everyone calls it. As Adam said, CpG distinguishes the dinucleotide from just a G-C base-pair. Graft | talk 22:09, 27 June 2008 (UTC)[reply]

Yes, but several textbooks refer to them as CG islands, I added a link from CG island here. Although they may be known as CpG islands they are also known as CG islands. Came back from a lecture today where my professor referred to CG islands. Searched wikipedia and no hits. CFCF (talk) 17:27, 6 October 2011 (UTC)[reply]

My lecturer said its the traditional name and many textbooks still use CpG. Her explanation for the 'p' was that it was to clarify that the cytosine is 5 prime to the guanine, which makes more sense to me than just distinguishing between the base pairing. 90.245.45.179 (talk) 14:13, 30 January 2013 (UTC)[reply]

Backbond?[edit]

The phrase linked by phosphodiester bonds, in the backbond of the DNA, should this refer to the backbone of the DNA? Otherwise it would be unlikely to refer to π backbonding (Organometallic chemistry). --apers0n 15:09, 21 January 2007 (UTC)[reply]

Merge with CpG site[edit]

Why not merge this page with CpG site? CpG site already even has a section called CpG island. Thatfeel (talk) 20:27, 20 December 2008 (UTC)[reply]

Possibly; it's a good bet that the reason CpG sites are special is because of the existence of CpG islands. However, they're fairly different phenomena; CpG sites occur all throughout the genome, and they're primarily important because of their mutagenic effect, whereas CpG islands are exclusively associated with promoters. Graft | talk 23:13, 20 December 2008 (UTC)[reply]

Didactically suboptimal[edit]

Like many bio-articles on Wikipedia this article is confusing and didactically suboptimal. E.g. the part about the CG supression should be in the introduction because it is important to point out why CpG is so much less frequently found than statistically expected. --Felix Tritschler (talk) 16:23, 11 December 2013 (UTC)[reply]