Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 19:59, 8 November 2007 (UTC)[edit]
Proteins without matches (19)[edit]
Proteins with a High Potential Match (6)[edit]
Created (10)[edit]
Manual Inspection (Page not found) (15)[edit]
Protein Status Grid - Date: 19:59, 8 November 2007 (UTC)[edit]
Vebose Log - Date: 19:59, 8 November 2007 (UTC)[edit]
- INFO: Beginning work on ACTN2... {November 8, 2007 11:23:19 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACTN2 image.jpg {November 8, 2007 11:24:46 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:24:54 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACTN2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h8b.
| PDB = {{PDB2|1h8b}}, {{PDB2|1hci}}, {{PDB2|1quu}}, {{PDB2|1tjt}}, {{PDB2|1wku}}
| Name = Actinin, alpha 2
| HGNCid = 164
| Symbol = ACTN2
| AltSymbols =;
| OMIM = 102573
| ECnumber =
| Homologene = 31016
| MGIid = 109192
| GeneAtlas_image1 = PBB_GE_ACTN2_203862_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ACTN2_203861_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ACTN2_203863_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}} {{GNF_GO|id=GO:0030375 |text = thyroid hormone receptor coactivator activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0051370 |text = ZASP binding}} {{GNF_GO|id=GO:0051374 |text = FATZ 1 binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005884 |text = actin filament}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}} {{GNF_GO|id=GO:0030018 |text = Z disc}} {{GNF_GO|id=GO:0030175 |text = filopodium}} {{GNF_GO|id=GO:0031143 |text = pseudopodium}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030035 |text = microspike biogenesis}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0048041 |text = focal adhesion formation}} {{GNF_GO|id=GO:0051289 |text = protein homotetramerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 88
| Hs_Ensembl = ENSG00000077522
| Hs_RefseqProtein = NP_001094
| Hs_RefseqmRNA = NM_001103
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 234916431
| Hs_GenLoc_end = 234994554
| Hs_Uniprot = P35609
| Mm_EntrezGene = 11472
| Mm_Ensembl = ENSMUSG00000052374
| Mm_RefseqmRNA = NM_033268
| Mm_RefseqProtein = NP_150371
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 12323759
| Mm_GenLoc_end = 12395065
| Mm_Uniprot = Q5FW75
}}
}}
'''Actinin, alpha 2''', also known as '''ACTN2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Transcript variants resulting from the use of multiple poly_A sites have been observed.<ref>{{cite web | title = Entrez Gene: ACTN2 actinin, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=88| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Faulkner G, Lanfranchi G, Valle G |title=Telethonin and other new proteins of the Z-disc of skeletal muscle. |journal=IUBMB Life |volume=51 |issue= 5 |pages= 275-82 |year= 2002 |pmid= 11699871 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ACTR3... {November 8, 2007 11:46:52 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACTR3 image.jpg {November 8, 2007 11:48:07 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:48:19 AM PST}
- CREATED: Created new protein page: ACTR3 {November 8, 2007 11:48:26 AM PST}
- INFO: Beginning work on APCS... {November 8, 2007 11:24:54 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein APCS image.jpg {November 8, 2007 11:25:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:25:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_APCS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gyk.
| PDB = {{PDB2|1gyk}}, {{PDB2|1lgn}}, {{PDB2|1sac}}, {{PDB2|2a3w}}, {{PDB2|2a3x}}, {{PDB2|2a3y}}
| Name = Amyloid P component, serum
| HGNCid = 584
| Symbol = APCS
| AltSymbols =; MGC88159; PTX2; SAP
| OMIM = 104770
| ECnumber =
| Homologene = 1239
| MGIid = 98229
| GeneAtlas_image1 = PBB_GE_APCS_206350_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0051131 |text = chaperone-mediated protein complex assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 325
| Hs_Ensembl = ENSG00000132703
| Hs_RefseqProtein = NP_001630
| Hs_RefseqmRNA = NM_001639
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 157824240
| Hs_GenLoc_end = 157825284
| Hs_Uniprot = P02743
| Mm_EntrezGene = 20219
| Mm_Ensembl = ENSMUSG00000026542
| Mm_RefseqmRNA = NM_011318
| Mm_RefseqProtein = NP_035448
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 174730637
| Mm_GenLoc_end = 174731718
| Mm_Uniprot = Q4JFI8
}}
}}
'''Amyloid P component, serum''', also known as '''APCS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. This gene has multiple polyadenylation sites.<ref>{{cite web | title = Entrez Gene: APCS amyloid P component, serum| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=325| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAPN2... {November 8, 2007 11:25:44 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CAPN2 image.jpg {November 8, 2007 11:26:16 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:26:40 AM PST}
- CREATED: Created new protein page: CAPN2 {November 8, 2007 11:26:47 AM PST}
- INFO: Beginning work on CD74... {November 8, 2007 11:26:47 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD74 image.jpg {November 8, 2007 11:27:23 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:27:39 AM PST}
- CREATED: Created new protein page: CD74 {November 8, 2007 11:27:46 AM PST}
- INFO: Beginning work on CDC25B... {November 8, 2007 11:27:46 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CDC25B image.jpg {November 8, 2007 11:28:18 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:28:26 AM PST}
- CREATED: Created new protein page: CDC25B {November 8, 2007 11:28:33 AM PST}
- INFO: Beginning work on CHRNA4... {November 8, 2007 11:28:33 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:30:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 4
| HGNCid = 1958
| Symbol = CHRNA4
| AltSymbols =; BFNC; EBN; EBN1; NACRA4
| OMIM = 118504
| ECnumber =
| Homologene = 592
| MGIid = 87888
| GeneAtlas_image1 = PBB_GE_CHRNA4_206735_at_tn.png
| GeneAtlas_image2 = PBB_GE_CHRNA4_206736_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CHRNA4_216900_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}} {{GNF_GO|id=GO:0030594 |text = neurotransmitter receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007271 |text = synaptic transmission, cholinergic}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1137
| Hs_Ensembl = ENSG00000101204
| Hs_RefseqProtein = NP_000735
| Hs_RefseqmRNA = NM_000744
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 61445864
| Hs_GenLoc_end = 61475777
| Hs_Uniprot = P43681
| Mm_EntrezGene = 11438
| Mm_Ensembl = ENSMUSG00000027577
| Mm_RefseqmRNA = NM_015730
| Mm_RefseqProtein = NP_056545
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 180951719
| Mm_GenLoc_end = 180968585
| Mm_Uniprot = Q53YK0
}}
}}
'''Cholinergic receptor, nicotinic, alpha 4''', also known as '''CHRNA4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors respond by undergoing an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene appear to account for a small proportion of the cases of nocturnal frontal lobe epilepsy.<ref>{{cite web | title = Entrez Gene: CHRNA4 cholinergic receptor, nicotinic, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1137| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Skorupska E, Rózycka A, Trzeciak WH |title=[Molecular and genetic basis of idiopathic nocturnal frontal lobe epilepsy] |journal=Neurol. Neurochir. Pol. |volume=36 |issue= 3 |pages= 513-25 |year= 2002 |pmid= 12185808 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRHR1... {November 8, 2007 11:30:04 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:31:46 AM PST}
- CREATED: Created new protein page: CRHR1 {November 8, 2007 11:31:55 AM PST}
- INFO: Beginning work on DEFB1... {November 8, 2007 11:33:47 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DEFB1 image.jpg {November 8, 2007 11:34:20 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:34:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DEFB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e4s.
| PDB = {{PDB2|1e4s}}, {{PDB2|1iju}}, {{PDB2|1ijv}}, {{PDB2|1kj5}}, {{PDB2|2nlb}}, {{PDB2|2nlc}}, {{PDB2|2nld}}, {{PDB2|2nle}}, {{PDB2|2nlf}}, {{PDB2|2nlg}}, {{PDB2|2nlh}}, {{PDB2|2nlp}}, {{PDB2|2nlq}}, {{PDB2|2nls}}
| Name = Defensin, beta 1
| HGNCid = 2766
| Symbol = DEFB1
| AltSymbols =; BD1; DEFB-1; DEFB101; HBD1; MGC51822
| OMIM = 602056
| ECnumber =
| Homologene = 88476
| MGIid =
| GeneAtlas_image1 = PBB_GE_DEFB1_210397_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1672
| Hs_Ensembl = ENSG00000164825
| Hs_RefseqProtein = NP_005209
| Hs_RefseqmRNA = NM_005218
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 6715511
| Hs_GenLoc_end = 6722939
| Hs_Uniprot = P60022
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Defensin, beta 1''', also known as '''DEFB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.<ref>{{cite web | title = Entrez Gene: DEFB1 defensin, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1672| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ganz T, Lehrer RI |title=Defensins. |journal=Pharmacol. Ther. |volume=66 |issue= 2 |pages= 191-205 |year= 1995 |pmid= 7667395 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DHX9... {November 8, 2007 11:31:55 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DHX9 image.jpg {November 8, 2007 11:33:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:33:47 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DHX9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uil.
| PDB = {{PDB2|1uil}}
| Name = DEAH (Asp-Glu-Ala-His) box polypeptide 9
| HGNCid = 2750
| Symbol = DHX9
| AltSymbols =; DDX9; LKP; NDH II; NDHII; RHA
| OMIM = 603115
| ECnumber =
| Homologene = 1039
| MGIid = 108177
| GeneAtlas_image1 = PBB_GE_DHX9_202420_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DHX9_212105_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DHX9_212107_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0004004 |text = ATP-dependent RNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1660
| Hs_Ensembl = ENSG00000135829
| Hs_RefseqProtein = NP_001348
| Hs_RefseqmRNA = NM_001357
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 181075127
| Hs_GenLoc_end = 181123510
| Hs_Uniprot = Q08211
| Mm_EntrezGene = 13211
| Mm_Ensembl = ENSMUSG00000042699
| Mm_RefseqmRNA = NM_007842
| Mm_RefseqProtein = NP_031868
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 155218031
| Mm_GenLoc_end = 155249826
| Mm_Uniprot = Q05BR6
}}
}}
'''DEAH (Asp-Glu-Ala-His) box polypeptide 9''', also known as '''DHX9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity.<ref>{{cite web | title = Entrez Gene: DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1660| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GABBR1... {November 8, 2007 11:34:39 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GABBR1 image.jpg {November 8, 2007 11:35:43 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:36:05 AM PST}
- CREATED: Created new protein page: GABBR1 {November 8, 2007 11:36:12 AM PST}
- INFO: Beginning work on GNA13... {November 8, 2007 11:48:26 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GNA13 image.jpg {November 8, 2007 11:49:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:49:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GNA13_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zcb.
| PDB = {{PDB2|1zcb}}
| Name = Guanine nucleotide binding protein (G protein), alpha 13
| HGNCid = 4381
| Symbol = GNA13
| AltSymbols =; G13; MGC46138
| OMIM = 604406
| ECnumber =
| Homologene = 55976
| MGIid = 95768
| GeneAtlas_image1 = PBB_GE_GNA13_206917_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10672
| Hs_Ensembl = ENSG00000120063
| Hs_RefseqProtein = NP_006563
| Hs_RefseqmRNA = NM_006572
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 60437296
| Hs_GenLoc_end = 60483216
| Hs_Uniprot = Q14344
| Mm_EntrezGene = 14674
| Mm_Ensembl = ENSMUSG00000020611
| Mm_RefseqmRNA = NM_010303
| Mm_RefseqProtein = NP_034433
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 109178921
| Mm_GenLoc_end = 109212576
| Mm_Uniprot = Q3UE40
}}
}}
'''Guanine nucleotide binding protein (G protein), alpha 13''', also known as '''GNA13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544-52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GNB1... {November 8, 2007 11:36:12 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GNB1 image.jpg {November 8, 2007 11:37:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:37:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GNB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a0r.
| PDB = {{PDB2|1a0r}}, {{PDB2|1b9x}}, {{PDB2|1b9y}}, {{PDB2|1gg2}}, {{PDB2|1got}}, {{PDB2|1gp2}}, {{PDB2|1omw}}, {{PDB2|1tbg}}, {{PDB2|1xhm}}, {{PDB2|2bcj}}, {{PDB2|2trc}}
| Name = Guanine nucleotide binding protein (G protein), beta polypeptide 1
| HGNCid = 4396
| Symbol = GNB1
| AltSymbols =;
| OMIM = 139380
| ECnumber =
| Homologene = 55532
| MGIid = 95781
| GeneAtlas_image1 = PBB_GE_GNB1_200745_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNB1_200744_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNB1_200746_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050909 |text = sensory perception of taste}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2782
| Hs_Ensembl = ENSG00000078369
| Hs_RefseqProtein = NP_002065
| Hs_RefseqmRNA = NM_002074
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 1706589
| Hs_GenLoc_end = 1812355
| Hs_Uniprot = P62873
| Mm_EntrezGene = 14688
| Mm_Ensembl = ENSMUSG00000029064
| Mm_RefseqmRNA = NM_008142
| Mm_RefseqProtein = NP_032168
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 154335170
| Mm_GenLoc_end = 154401618
| Mm_Uniprot = Q3TQ70
}}
}}
'''Guanine nucleotide binding protein (G protein), beta polypeptide 1''', also known as '''GNB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.<ref>{{cite web | title = Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2782| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544-52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GNRH1... {November 8, 2007 11:37:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:38:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
| HGNCid = 4419
| Symbol = GNRH1
| AltSymbols =; GNRH; GRH; LHRH; LNRH
| OMIM = 152760
| ECnumber =
| Homologene = 641
| MGIid = 95789
| GeneAtlas_image1 = PBB_GE_GNRH1_207987_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005183 |text = luteinizing hormone-releasing factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2796
| Hs_Ensembl = ENSG00000147437
| Hs_RefseqProtein = NP_000816
| Hs_RefseqmRNA = NM_000825
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 25332697
| Hs_GenLoc_end = 25338087
| Hs_Uniprot = P01148
| Mm_EntrezGene = 14714
| Mm_Ensembl = ENSMUSG00000015812
| Mm_RefseqmRNA = NM_008145
| Mm_RefseqProtein = NP_032171
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 66699676
| Mm_GenLoc_end = 66702621
| Mm_Uniprot = Q14AC4
}}
}}
'''Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)''', also known as '''GNRH1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flanagan CA, Millar RP, Illing N |title=Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions. |journal=Rev. Reprod. |volume=2 |issue= 2 |pages= 113-20 |year= 1998 |pmid= 9414473 |doi= }}
*{{cite journal | author=Leung PC, Cheng CK, Zhu XM |title=Multi-factorial role of GnRH-I and GnRH-II in the human ovary. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 145-53 |year= 2004 |pmid= 12770744 |doi= }}
*{{cite journal | author=Gründker C, Emons G |title=Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. |journal=Reprod. Biol. Endocrinol. |volume=1 |issue= |pages= 65 |year= 2004 |pmid= 14594454 |doi= 10.1186/1477-7827-1-65 }}
*{{cite journal | author=Limonta P, Moretti RM, Marelli MM, Motta M |title=The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. |journal=Frontiers in neuroendocrinology |volume=24 |issue= 4 |pages= 279-95 |year= 2004 |pmid= 14726258 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HIST4H4... {November 8, 2007 11:50:41 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIST4H4 image.jpg {November 8, 2007 11:50:55 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:51:05 AM PST}
- CREATED: Created new protein page: HIST4H4 {November 8, 2007 11:51:12 AM PST}
- INFO: Beginning work on HNRPA2B1... {November 8, 2007 11:38:12 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HNRPA2B1 image.jpg {November 8, 2007 11:38:53 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:39:13 AM PST}
- CREATED: Created new protein page: HNRPA2B1 {November 8, 2007 11:39:32 AM PST}
- INFO: Beginning work on ICOS... {November 8, 2007 11:49:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:50:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inducible T-cell co-stimulator
| HGNCid = 5351
| Symbol = ICOS
| AltSymbols =; AILIM; CD278; MGC39850
| OMIM = 604558
| ECnumber =
| Homologene = 8097
| MGIid = 1858745
| GeneAtlas_image1 = PBB_GE_ICOS_210439_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 29851
| Hs_Ensembl = ENSG00000163600
| Hs_RefseqProtein = NP_036224
| Hs_RefseqmRNA = NM_012092
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 204509716
| Hs_GenLoc_end = 204534541
| Hs_Uniprot = Q9Y6W8
| Mm_EntrezGene = 54167
| Mm_Ensembl = ENSMUSG00000026009
| Mm_RefseqmRNA = NM_017480
| Mm_RefseqProtein = NP_059508
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 60922460
| Mm_GenLoc_end = 60944866
| Mm_Uniprot = Q3V3X2
}}
}}
'''Inducible T-cell co-stimulator''', also known as '''ICOS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.<ref>{{cite web | title = Entrez Gene: ICOS inducible T-cell co-stimulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29851| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flesch IE |title=Inducible costimulator (ICOS). |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 214-6 |year= 2003 |pmid= 12456021 |doi= }}
*{{cite journal | author=Shilling RA, Bandukwala HS, Sperling AI |title=Regulation of T:B cell interactions by the inducible costimulator molecule: does ICOS "induce" disease? |journal=Clin. Immunol. |volume=121 |issue= 1 |pages= 13-8 |year= 2006 |pmid= 16790364 |doi= 10.1016/j.clim.2006.04.574 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IDE... {November 8, 2007 11:39:32 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IDE image.jpg {November 8, 2007 11:40:48 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:41:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IDE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2g47.
| PDB = {{PDB2|2g47}}, {{PDB2|2g48}}, {{PDB2|2g49}}, {{PDB2|2g54}}, {{PDB2|2g56}}
| Name = Insulin-degrading enzyme
| HGNCid = 5381
| Symbol = IDE
| AltSymbols =; FLJ35968; INSULYSIN
| OMIM = 146680
| ECnumber =
| Homologene = 3645
| MGIid = 96412
| GeneAtlas_image1 = PBB_GE_IDE_203327_at_tn.png
| GeneAtlas_image2 = PBB_GE_IDE_203328_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_IDE_217496_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004231 |text = insulysin activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005777 |text = peroxisome}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3416
| Hs_Ensembl = ENSG00000119912
| Hs_RefseqProtein = NP_004960
| Hs_RefseqmRNA = NM_004969
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 94201421
| Hs_GenLoc_end = 94323813
| Hs_Uniprot = P14735
| Mm_EntrezGene = 15925
| Mm_Ensembl = ENSMUSG00000056999
| Mm_RefseqmRNA = XM_974712
| Mm_RefseqProtein = XP_979806
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 37335574
| Mm_GenLoc_end = 37395757
| Mm_Uniprot = Q8CGB9
}}
}}
'''Insulin-degrading enzyme''', also known as '''IDE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene may belong to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.<ref>{{cite web | title = Entrez Gene: IDE insulin-degrading enzyme| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3416| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL16... {November 8, 2007 11:41:01 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL16 image.jpg {November 8, 2007 11:41:52 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:42:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IL16_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i16.
| PDB = {{PDB2|1i16}}, {{PDB2|1x6d}}
| Name = Interleukin 16 (lymphocyte chemoattractant factor)
| HGNCid = 5980
| Symbol = IL16
| AltSymbols =; FLJ16806; FLJ42735; FLJ44234; HsT19289; IL-16; LCF; prIL-16
| OMIM = 603035
| ECnumber =
| Homologene = 18157
| MGIid = 1270855
| GeneAtlas_image1 = PBB_GE_IL16_209827_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IL16_209828_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0030595 |text = leukocyte chemotaxis}} {{GNF_GO|id=GO:0050930 |text = induction of positive chemotaxis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3603
| Hs_Ensembl = ENSG00000172349
| Hs_RefseqProtein = NP_004504
| Hs_RefseqmRNA = NM_004513
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 79262148
| Hs_GenLoc_end = 79388491
| Hs_Uniprot = Q14005
| Mm_EntrezGene = 16170
| Mm_Ensembl = ENSMUSG00000001741
| Mm_RefseqmRNA = NM_010551
| Mm_RefseqProtein = NP_034681
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 83519249
| Mm_GenLoc_end = 83611708
| Mm_Uniprot = Q3UZ81
}}
}}
'''Interleukin 16 (lymphocyte chemoattractant factor)''', also known as '''IL16''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3603| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wilson KC, Center DM, Cruikshank WW |title=The effect of interleukin-16 and its precursor on T lymphocyte activation and growth. |journal=Growth Factors |volume=22 |issue= 2 |pages= 97-104 |year= 2005 |pmid= 15253385 |doi= }}
*{{cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093-101 |year= 2006 |pmid= 16375755 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on INHBB... {November 8, 2007 11:42:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:42:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inhibin, beta B (activin AB beta polypeptide)
| HGNCid = 6067
| Symbol = INHBB
| AltSymbols =;
| OMIM = 147390
| ECnumber =
| Homologene = 1654
| MGIid = 96571
| GeneAtlas_image1 = PBB_GE_INHBB_205258_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046789 |text = host cell surface receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0009605 |text = response to external stimulus}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0040007 |text = growth}} {{GNF_GO|id=GO:0046881 |text = positive regulation of follicle-stimulating hormone secretion}} {{GNF_GO|id=GO:0046882 |text = negative regulation of follicle-stimulating hormone secretion}} {{GNF_GO|id=GO:0048178 |text = negative regulation of hepatocyte growth factor biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3625
| Hs_Ensembl = ENSG00000163083
| Hs_RefseqProtein = NP_002184
| Hs_RefseqmRNA = NM_002193
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 120819469
| Hs_GenLoc_end = 120825444
| Hs_Uniprot = P09529
| Mm_EntrezGene = 16324
| Mm_Ensembl = ENSMUSG00000037035
| Mm_RefseqmRNA = XM_984243
| Mm_RefseqProtein = XP_989337
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 121243011
| Mm_GenLoc_end = 121249794
| Mm_Uniprot = Q04999
}}
}}
'''Inhibin, beta B (activin AB beta polypeptide)''', also known as '''INHBB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.<ref>{{cite web | title = Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3625| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ying SY |title=Inhibins and activins: chemical properties and biological activity. |journal=Proc. Soc. Exp. Biol. Med. |volume=186 |issue= 3 |pages= 253-64 |year= 1988 |pmid= 3122219 |doi= }}
*{{cite journal | author=Munz B, Hübner G, Tretter Y, ''et al.'' |title=A novel role of activin in inflammation and repair. |journal=J. Endocrinol. |volume=161 |issue= 2 |pages= 187-93 |year= 1999 |pmid= 10320815 |doi= }}
*{{cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317-23 |year= 2002 |pmid= 12032389 |doi= }}
*{{cite journal | author=Shav-Tal Y, Zipori D |title=The role of activin a in regulation of hemopoiesis. |journal=Stem Cells |volume=20 |issue= 6 |pages= 493-500 |year= 2003 |pmid= 12456957 |doi= }}
*{{cite journal | author=Lahlou N, Roger M |title=Inhibin B in pubertal development and pubertal disorders. |journal=Semin. Reprod. Med. |volume=22 |issue= 3 |pages= 165-75 |year= 2005 |pmid= 15319819 |doi= 10.1055/s-2004-831892 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MVP... {November 8, 2007 11:45:12 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MVP image.jpg {November 8, 2007 11:46:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:46:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MVP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y7x.
| PDB = {{PDB2|1y7x}}
| Name = Major vault protein
| HGNCid = 7531
| Symbol = MVP
| AltSymbols =; LRP; VAULT1
| OMIM = 605088
| ECnumber =
| Homologene = 3752
| MGIid = 1925638
| GeneAtlas_image1 = PBB_GE_MVP_202180_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MVP_gnf1h10986_at_tn.png
| GeneAtlas_image3 = PBB_GE_MVP_gnf1h10989_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0042493 |text = response to drug}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9961
| Hs_Ensembl = ENSG00000013364
| Hs_RefseqProtein = NP_005106
| Hs_RefseqmRNA = NM_005115
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 29739281
| Hs_GenLoc_end = 29766842
| Hs_Uniprot = Q14764
| Mm_EntrezGene = 78388
| Mm_Ensembl = ENSMUSG00000030681
| Mm_RefseqmRNA = NM_080638
| Mm_RefseqProtein = NP_542369
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 126778012
| Mm_GenLoc_end = 126805742
| Mm_Uniprot = Q3THX5
}}
}}
'''Major vault protein''', also known as '''MVP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.<ref>{{cite web | title = Entrez Gene: MVP major vault protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9961| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Izquierdo MA, Scheffer GL, Flens MJ, ''et al.'' |title=Major vault protein LRP-related multidrug resistance. |journal=Eur. J. Cancer |volume=32A |issue= 6 |pages= 979-84 |year= 1996 |pmid= 8763338 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR0B2... {November 8, 2007 11:44:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:45:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor subfamily 0, group B, member 2
| HGNCid = 7961
| Symbol = NR0B2
| AltSymbols =; SHP1; SHP
| OMIM = 604630
| ECnumber =
| Homologene = 8030
| MGIid = 1346344
| GeneAtlas_image1 = PBB_GE_NR0B2_206410_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8431
| Hs_Ensembl = ENSG00000131910
| Hs_RefseqProtein = NP_068804
| Hs_RefseqmRNA = NM_021969
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 27110566
| Hs_GenLoc_end = 27113047
| Hs_Uniprot = Q15466
| Mm_EntrezGene = 23957
| Mm_Ensembl = ENSMUSG00000037583
| Mm_RefseqmRNA = NM_011850
| Mm_RefseqProtein = NP_035980
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 132825456
| Mm_GenLoc_end = 132828611
| Mm_Uniprot = Q62227
}}
}}
'''Nuclear receptor subfamily 0, group B, member 2''', also known as '''NR0B2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.<ref>{{cite web | title = Entrez Gene: NR0B2 nuclear receptor subfamily 0, group B, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8431| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SH3KBP1... {November 8, 2007 11:50:01 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SH3KBP1 image.jpg {November 8, 2007 11:50:20 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:50:34 AM PST}
- CREATED: Created new protein page: SH3KBP1 {November 8, 2007 11:50:41 AM PST}
- INFO: Beginning work on WEE1... {November 8, 2007 11:42:49 AM PST}
- UPLOAD: Added new Image to wiki:
{November 8, 2007 11:43:09 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:43:23 AM PST}
- CREATED: Created new protein page: WEE1 {November 8, 2007 11:43:30 AM PST}
- INFO: Beginning work on XPA... {November 8, 2007 11:43:30 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein XPA image.jpg {November 8, 2007 11:44:14 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:44:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_XPA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d4u.
| PDB = {{PDB2|1d4u}}, {{PDB2|1xpa}}
| Name = Xeroderma pigmentosum, complementation group A
| HGNCid = 12814
| Symbol = XPA
| AltSymbols =; XP1; XPAC
| OMIM = 278700
| ECnumber =
| Homologene = 37298
| MGIid = 99135
| GeneAtlas_image1 = PBB_GE_XPA_205672_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7507
| Hs_Ensembl = ENSG00000136936
| Hs_RefseqProtein = NP_000371
| Hs_RefseqmRNA = NM_000380
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 99477012
| Hs_GenLoc_end = 99499460
| Hs_Uniprot = P23025
| Mm_EntrezGene = 22590
| Mm_Ensembl = ENSMUSG00000028329
| Mm_RefseqmRNA = NM_011728
| Mm_RefseqProtein = NP_035858
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 46176448
| Mm_GenLoc_end = 46217411
| Mm_Uniprot = Q8R4W5
}}
}}
'''Xeroderma pigmentosum, complementation group A''', also known as '''XPA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cleaver JE, Thompson LH, Richardson AS, States JC |title=A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. |journal=Hum. Mutat. |volume=14 |issue= 1 |pages= 9-22 |year= 1999 |pmid= 10447254 |doi= 10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 }}
*{{cite journal | author=Morikawa K, Shirakawa M |title=Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA. |journal=Mutat. Res. |volume=460 |issue= 3-4 |pages= 257-75 |year= 2000 |pmid= 10946233 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
