Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 22:36, 1 November 2007 (UTC)[edit]
Proteins without matches (16)[edit]
Proteins with a High Potential Match (8)[edit]
Redirected Proteins (1)[edit]
Created (6)[edit]
Manual Inspection (Page not found) (18)[edit]
Updated (1)[edit]
Protein Status Grid - Date: 22:36, 1 November 2007 (UTC)[edit]
Vebose Log - Date: 22:36, 1 November 2007 (UTC)[edit]
- INFO: Beginning work on BCR... {November 1, 2007 3:05:47 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 3:06:11 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:06:34 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BCR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k1f.
| PDB = {{PDB2|1k1f}}
| Name = Breakpoint cluster region
| HGNCid = 1014
| Symbol = BCR
| AltSymbols =; ALL; BCR/FGFR1; BCR1; CML; D22S11; D22S662; FGFR1/BCR; FLJ16453; PHL
| OMIM = 151410
| ECnumber =
| Homologene = 3192
| MGIid = 88141
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 613
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004318
| Hs_RefseqmRNA = NM_004327
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 110279
| Mm_Ensembl = ENSMUSG00000009681
| Mm_RefseqmRNA = XM_898043
| Mm_RefseqProtein = XP_903136
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 74505374
| Mm_GenLoc_end = 74626498
| Mm_Uniprot =
}}
}}
'''Breakpoint cluster region''', also known as '''BCR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: BCR breakpoint cluster region| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=613| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wang L, Seale J, Woodcock BE, Clark RE |title=e19a2-positive chronic myeloid leukaemia with BCR exon e16-deleted transcripts. |journal=Leukemia |volume=16 |issue= 8 |pages= 1562-3 |year= 2002 |pmid= 12145699 |doi= 10.1038/sj.leu.2402600 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BTK... {November 1, 2007 3:06:34 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein BTK image.jpg {November 1, 2007 3:07:08 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:07:35 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BTK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aww.
| PDB = {{PDB2|1aww}}, {{PDB2|1awx}}, {{PDB2|1b55}}, {{PDB2|1btk}}, {{PDB2|1bwn}}, {{PDB2|1k2p}}, {{PDB2|1qly}}, {{PDB2|2ge9}}
| Name = Bruton agammaglobulinemia tyrosine kinase
| HGNCid = 1133
| Symbol = BTK
| AltSymbols =; AGMX1; AT; ATK; BPK; IMD1; MGC126261; MGC126262; PSCTK1; XLA
| OMIM = 300300
| ECnumber =
| Homologene = 30953
| MGIid = 88216
| GeneAtlas_image1 = PBB_GE_BTK_205504_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0031410 |text = cytoplasmic vesicle}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 695
| Hs_Ensembl = ENSG00000010671
| Hs_RefseqProtein = NP_000052
| Hs_RefseqmRNA = NM_000061
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 100491091
| Hs_GenLoc_end = 100527839
| Hs_Uniprot = Q06187
| Mm_EntrezGene = 12229
| Mm_Ensembl = ENSMUSG00000031264
| Mm_RefseqmRNA = NM_013482
| Mm_RefseqProtein = NP_038510
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 129888686
| Mm_GenLoc_end = 129929418
| Mm_Uniprot = Q7TMU1
}}
}}
'''Bruton agammaglobulinemia tyrosine kinase''', also known as '''BTK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Defects in the Bruton tyrosine kinase (BTK) gene cause Agammaglobulinemia. Agammaglobulinemia is an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement.<ref>{{cite web | title = Entrez Gene: BTK Bruton agammaglobulinemia tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=695| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ochs HD, Aruffo A |title=Advances in X-linked immunodeficiency diseases. |journal=Curr. Opin. Pediatr. |volume=5 |issue= 6 |pages= 684-91 |year= 1994 |pmid= 7907259 |doi= }}
*{{cite journal | author=Uckun FM |title=Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. |journal=Biochem. Pharmacol. |volume=56 |issue= 6 |pages= 683-91 |year= 1998 |pmid= 9751072 |doi= }}
*{{cite journal | author=Tsubata T, Wienands J |title=B cell signaling. Introduction. |journal=Int. Rev. Immunol. |volume=20 |issue= 6 |pages= 675-8 |year= 2002 |pmid= 11913944 |doi= }}
*{{cite journal | author=Etzioni A |title=Novel aspects of hypogammaglobulinemic states. |journal=Isr. Med. Assoc. J. |volume=4 |issue= 4 |pages= 294-7 |year= 2002 |pmid= 12001708 |doi= }}
*{{cite journal | author=Niiro H, Clark EA |title=Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. |journal=Immunity |volume=19 |issue= 5 |pages= 637-40 |year= 2003 |pmid= 14614850 |doi= }}
*{{cite journal | author=Carpenter CL |title=Btk-dependent regulation of phosphoinositide synthesis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 326-9 |year= 2004 |pmid= 15046600 |doi= 10.1042/ }}
*{{cite journal | author=Hendriks RW, Kersseboom R |title=Involvement of SLP-65 and Btk in tumor suppression and malignant transformation of pre-B cells. |journal=Semin. Immunol. |volume=18 |issue= 1 |pages= 67-76 |year= 2006 |pmid= 16300960 |doi= 10.1016/j.smim.2005.10.002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL1A2... {November 1, 2007 3:07:35 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:08:40 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type I, alpha 2
| HGNCid = 2198
| Symbol = COL1A2
| AltSymbols =; OI4
| OMIM = 120160
| ECnumber =
| Homologene = 69
| MGIid = 88468
| GeneAtlas_image1 = PBB_GE_COL1A2_202403_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL1A2_202404_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008147 |text = structural constituent of bone}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005584 |text = collagen type I}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1278
| Hs_Ensembl = ENSG00000164692
| Hs_RefseqProtein = NP_000080
| Hs_RefseqmRNA = NM_000089
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 93861809
| Hs_GenLoc_end = 93898480
| Hs_Uniprot = P08123
| Mm_EntrezGene = 12843
| Mm_Ensembl = ENSMUSG00000029661
| Mm_RefseqmRNA = NM_007743
| Mm_RefseqProtein = NP_031769
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 4455840
| Mm_GenLoc_end = 4490729
| Mm_Uniprot = Q3TP88
}}
}}
'''Collagen, type I, alpha 2''', also known as '''COL1A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes.<ref>{{cite web | title = Entrez Gene: COL1A2 collagen, type I, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1278| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Byers PH, Wallis GA, Willing MC |title=Osteogenesis imperfecta: translation of mutation to phenotype. |journal=J. Med. Genet. |volume=28 |issue= 7 |pages= 433-42 |year= 1991 |pmid= 1895312 |doi= }}
*{{cite journal | author=Kuivaniemi H, Tromp G, Prockop DJ |title=Mutations in collagen genes: causes of rare and some common diseases in humans. |journal=FASEB J. |volume=5 |issue= 7 |pages= 2052-60 |year= 1991 |pmid= 2010058 |doi= }}
*{{cite journal | author=Kuivaniemi H, Tromp G, Prockop DJ |title=Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. |journal=Hum. Mutat. |volume=9 |issue= 4 |pages= 300-15 |year= 1997 |pmid= 9101290 |doi= 10.1002/(SICI)1098-1004(1997)9:4<300::AID-HUMU2>3.0.CO;2-9 }}
*{{cite journal | author=Rossert J, Terraz C, Dupont S |title=Regulation of type I collagen genes expression. |journal=Nephrol. Dial. Transplant. |volume=15 Suppl 6 |issue= |pages= 66-8 |year= 2001 |pmid= 11143996 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CREB1... {November 1, 2007 3:08:40 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 3:10:17 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:10:30 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CREB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dh3.
| PDB = {{PDB2|1dh3}}
| Name = CAMP responsive element binding protein 1
| HGNCid = 2345
| Symbol = CREB1
| AltSymbols =; CREB; MGC9284
| OMIM = 123810
| ECnumber =
| Homologene = 3223
| MGIid = 88494
| GeneAtlas_image1 = PBB_GE_CREB1_204313_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CREB1_204312_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CREB1_204314_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0008361 |text = regulation of cell size}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1385
| Hs_Ensembl = ENSG00000118260
| Hs_RefseqProtein = NP_004370
| Hs_RefseqmRNA = NM_004379
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 208102931
| Hs_GenLoc_end = 208171806
| Hs_Uniprot = P16220
| Mm_EntrezGene = 12912
| Mm_Ensembl = ENSMUSG00000025958
| Mm_RefseqmRNA = NM_009952
| Mm_RefseqProtein = NP_034082
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 64467080
| Mm_GenLoc_end = 64538826
| Mm_Uniprot = Q547S9
}}
}}
'''CAMP responsive element binding protein 1''', also known as '''CREB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: CREB1 cAMP responsive element binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1385| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Don J, Stelzer G |title=The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 115-24 |year= 2003 |pmid= 11988318 |doi= }}
*{{cite journal | author=Pandey SC |title=The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. |journal=Pharmacol. Ther. |volume=104 |issue= 1 |pages= 47-58 |year= 2005 |pmid= 15500908 |doi= 10.1016/j.pharmthera.2004.08.002 }}
*{{cite journal | author=Wu H, Zhou Y, Xiong ZQ |title=Transducer of regulated CREB and late phase long-term synaptic potentiation. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3218-23 |year= 2007 |pmid= 17565597 |doi= 10.1111/j.1742-4658.2007.05891.x }}
*{{cite journal | author=Kitagawa K |title=CREB and cAMP response element-mediated gene expression in the ischemic brain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3210-7 |year= 2007 |pmid= 17565598 |doi= 10.1111/j.1742-4658.2007.05890.x }}
*{{cite journal | author=Takemori H, Kajimura J, Okamoto M |title=TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3202-9 |year= 2007 |pmid= 17565599 |doi= 10.1111/j.1742-4658.2007.05889.x }}
*{{cite journal | author=Siu YT, Jin DY |title=CREB--a real culprit in oncogenesis. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3224-32 |year= 2007 |pmid= 17565603 |doi= 10.1111/j.1742-4658.2007.05884.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSNK2A2... {November 1, 2007 3:10:30 PM PDT}
- SEARCH REDIRECT: Control Box Found: CSNK2A1 {November 1, 2007 3:12:31 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 1, 2007 3:12:33 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 1, 2007 3:12:33 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 1, 2007 3:12:33 PM PDT}
- UPDATED: Updated protein page: CSNK2A1 {November 1, 2007 3:12:39 PM PDT}
- INFO: Beginning work on CYP1A1... {November 1, 2007 3:12:39 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:13:33 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 1, subfamily A, polypeptide 1
| HGNCid = 2595
| Symbol = CYP1A1
| AltSymbols =; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
| OMIM = 108330
| ECnumber =
| Homologene = 68062
| MGIid = 88588
| GeneAtlas_image1 = PBB_GE_CYP1A1_205749_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1543
| Hs_Ensembl = ENSG00000140465
| Hs_RefseqProtein = NP_000490
| Hs_RefseqmRNA = NM_000499
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 72798943
| Hs_GenLoc_end = 72802491
| Hs_Uniprot = P04798
| Mm_EntrezGene = 13076
| Mm_Ensembl = ENSMUSG00000032315
| Mm_RefseqmRNA = XM_972645
| Mm_RefseqProtein = XP_977739
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 57449522
| Mm_GenLoc_end = 57501958
| Mm_Uniprot = Q05A20
}}
}}
'''Cytochrome P450, family 1, subfamily A, polypeptide 1''', also known as '''CYP1A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.<ref>{{cite web | title = Entrez Gene: CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1543| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beresford AP |title=CYP1A1: friend or foe? |journal=Drug Metab. Rev. |volume=25 |issue= 4 |pages= 503-17 |year= 1994 |pmid= 8313840 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Kawajiri K |title=CYP1A1. |journal=IARC Sci. Publ. |volume= |issue= 148 |pages= 159-72 |year= 1999 |pmid= 10493257 |doi= }}
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1-18 |year= 2004 |pmid= 15128046 |doi= }}
*{{cite journal | author=Masson LF, Sharp L, Cotton SC, Little J |title=Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review. |journal=Am. J. Epidemiol. |volume=161 |issue= 10 |pages= 901-15 |year= 2005 |pmid= 15870154 |doi= 10.1093/aje/kwi121 }}
*{{cite journal | author=Hildebrandt AG, Schwarz D, Krusekopf S, ''et al.'' |title=Recalling P446. P4501A1 (CYP1A1) opting for clinical application. |journal=Drug Metab. Rev. |volume=39 |issue= 2-3 |pages= 323-41 |year= 2007 |pmid= 17786624 |doi= 10.1080/03602530701498026 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F7... {November 1, 2007 3:13:33 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein F7 image.jpg {November 1, 2007 3:14:10 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:14:19 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_F7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bf9.
| PDB = {{PDB2|1bf9}}, {{PDB2|1cvw}}, {{PDB2|1dan}}, {{PDB2|1dva}}, {{PDB2|1f7e}}, {{PDB2|1f7m}}, {{PDB2|1fak}}, {{PDB2|1ff7}}, {{PDB2|1ffm}}, {{PDB2|1j9c}}, {{PDB2|1jbu}}, {{PDB2|1kli}}, {{PDB2|1klj}}, {{PDB2|1o5d}}, {{PDB2|1qfk}}, {{PDB2|1w0y}}, {{PDB2|1w2k}}, {{PDB2|1w7x}}, {{PDB2|1w8b}}, {{PDB2|1wqv}}, {{PDB2|1wss}}, {{PDB2|1wtg}}, {{PDB2|1wun}}, {{PDB2|1wv7}}, {{PDB2|1ygc}}, {{PDB2|1z6j}}, {{PDB2|2a2q}}, {{PDB2|2aei}}, {{PDB2|2aer}}, {{PDB2|2b7d}}, {{PDB2|2b8o}}, {{PDB2|2bz6}}, {{PDB2|2c4f}}, {{PDB2|2f9b}}, {{PDB2|2fir}}, {{PDB2|2flb}}, {{PDB2|2flr}}, {{PDB2|2puq}}
| Name = Coagulation factor VII (serum prothrombin conversion accelerator)
| HGNCid = 3544
| Symbol = F7
| AltSymbols =;
| OMIM = 227500
| ECnumber =
| Homologene = 7710
| MGIid = 109325
| GeneAtlas_image1 = PBB_GE_F7_207300_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003802 |text = coagulation factor VIIa activity}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2155
| Hs_Ensembl = ENSG00000057593
| Hs_RefseqProtein = NP_000122
| Hs_RefseqmRNA = NM_000131
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 112808106
| Hs_GenLoc_end = 112822996
| Hs_Uniprot = P08709
| Mm_EntrezGene = 14068
| Mm_Ensembl = ENSMUSG00000031443
| Mm_RefseqmRNA = NM_010172
| Mm_RefseqProtein = NP_034302
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 13026011
| Mm_GenLoc_end = 13035782
| Mm_Uniprot = Q542C2
}}
}}
'''Coagulation factor VII (serum prothrombin conversion accelerator)''', also known as '''F7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.<ref>{{cite web | title = Entrez Gene: F7 coagulation factor VII (serum prothrombin conversion accelerator)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2155| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Versteeg HH, Peppelenbosch MP, Spek CA |title=The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling? |journal=Thromb. Haemost. |volume=86 |issue= 6 |pages= 1353-9 |year= 2002 |pmid= 11776298 |doi= }}
*{{cite journal | author=Golino P |title=The inhibitors of the tissue factor:factor VII pathway. |journal=Thromb. Res. |volume=106 |issue= 3 |pages= V257-65 |year= 2003 |pmid= 12356487 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F9... {November 1, 2007 3:14:19 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein F9 image.jpg {November 1, 2007 3:14:52 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:15:12 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_F9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cfh.
| PDB = {{PDB2|1cfh}}, {{PDB2|1cfi}}, {{PDB2|1edm}}, {{PDB2|1ixa}}, {{PDB2|1j34}}, {{PDB2|1j35}}, {{PDB2|1mgx}}, {{PDB2|1nl0}}, {{PDB2|1rfn}}
| Name = Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
| HGNCid = 3551
| Symbol = F9
| AltSymbols =; FIX; GLA domain; HEMB; MGC129641; MGC129642; PTC
| OMIM = 306900
| ECnumber =
| Homologene = 106
| MGIid = 88384
| GeneAtlas_image1 = PBB_GE_F9_207218_at_tn.png
| Function = {{GNF_GO|id=GO:0003803 |text = coagulation factor IXa activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2158
| Hs_Ensembl = ENSG00000101981
| Hs_RefseqProtein = NP_000124
| Hs_RefseqmRNA = NM_000133
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 138440561
| Hs_GenLoc_end = 138473283
| Hs_Uniprot = P00740
| Mm_EntrezGene = 14071
| Mm_Ensembl = ENSMUSG00000031138
| Mm_RefseqmRNA = NM_007979
| Mm_RefseqProtein = NP_032005
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 56346248
| Mm_GenLoc_end = 56377542
| Mm_Uniprot = A0JLY3
}}
}}
'''Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)''', also known as '''F9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.<ref>{{cite web | title = Entrez Gene: F9 coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2158| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Davie EW, Fujikawa K |title=Basic mechanisms in blood coagulation. |journal=Annu. Rev. Biochem. |volume=44 |issue= |pages= 799-829 |year= 1975 |pmid= 237463 |doi= 10.1146/annurev.bi.44.070175.004055 }}
*{{cite journal | author=Sommer SS |title=Assessing the underlying pattern of human germline mutations: lessons from the factor IX gene. |journal=FASEB J. |volume=6 |issue= 10 |pages= 2767-74 |year= 1992 |pmid= 1634040 |doi= }}
*{{cite journal | author=Lenting PJ, van Mourik JA, Mertens K |title=The life cycle of coagulation factor VIII in view of its structure and function. |journal=Blood |volume=92 |issue= 11 |pages= 3983-96 |year= 1999 |pmid= 9834200 |doi= }}
*{{cite journal | author=Lowe GD |title=Factor IX and thrombosis. |journal=Br. J. Haematol. |volume=115 |issue= 3 |pages= 507-13 |year= 2002 |pmid= 11736930 |doi= }}
*{{cite journal | author=O'Connell NM |title=Factor XI deficiency--from molecular genetics to clinical management. |journal=Blood Coagul. Fibrinolysis |volume=14 Suppl 1 |issue= |pages= S59-64 |year= 2004 |pmid= 14567539 |doi= }}
*{{cite journal | author=Du X |title=Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. |journal=Curr. Opin. Hematol. |volume=14 |issue= 3 |pages= 262-9 |year= 2007 |pmid= 17414217 |doi= 10.1097/MOH.0b013e3280dce51a }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FBN1... {November 1, 2007 3:15:12 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein FBN1 image.jpg {November 1, 2007 3:16:10 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:16:34 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FBN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1apj.
| PDB = {{PDB2|1apj}}, {{PDB2|1emn}}, {{PDB2|1emo}}, {{PDB2|1lmj}}, {{PDB2|1uzj}}, {{PDB2|1uzk}}, {{PDB2|1uzp}}, {{PDB2|1uzq}}
| Name = Fibrillin 1
| HGNCid = 3603
| Symbol = FBN1
| AltSymbols =; FBN; MASS; MFS1; OCTD; SGS; WMS
| OMIM = 134797
| ECnumber =
| Homologene = 30958
| MGIid = 95489
| GeneAtlas_image1 = PBB_GE_FBN1_202766_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FBN1_202765_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0001527 |text = microfibril}} {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2200
| Hs_Ensembl = ENSG00000166147
| Hs_RefseqProtein = NP_000129
| Hs_RefseqmRNA = NM_000138
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 46489479
| Hs_GenLoc_end = 46724391
| Hs_Uniprot = P35555
| Mm_EntrezGene = 14118
| Mm_Ensembl = ENSMUSG00000027204
| Mm_RefseqmRNA = NM_007993
| Mm_RefseqProtein = NP_032019
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 124992035
| Mm_GenLoc_end = 125199434
| Mm_Uniprot = Q3TRZ5
}}
}}
'''Fibrillin 1''', also known as '''FBN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.<ref>{{cite web | title = Entrez Gene: FBN1 fibrillin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2200| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hayward C, Brock DJ |title=Fibrillin-1 mutations in Marfan syndrome and other type-1 fibrillinopathies. |journal=Hum. Mutat. |volume=10 |issue= 6 |pages= 415-23 |year= 1998 |pmid= 9401003 |doi= 10.1002/(SICI)1098-1004(1997)10:6<415::AID-HUMU1>3.0.CO;2-C }}
*{{cite journal | author=Robinson PN, Godfrey M |title=The molecular genetics of Marfan syndrome and related microfibrillopathies. |journal=J. Med. Genet. |volume=37 |issue= 1 |pages= 9-25 |year= 2000 |pmid= 10633129 |doi= }}
*{{cite journal | author=Handford PA |title=Fibrillin-1, a calcium binding protein of extracellular matrix. |journal=Biochim. Biophys. Acta |volume=1498 |issue= 2-3 |pages= 84-90 |year= 2001 |pmid= 11108952 |doi= }}
*{{cite journal | author=Robinson PN, Booms P, Katzke S, ''et al.'' |title=Mutations of FBN1 and genotype-phenotype correlations in Marfan syndrome and related fibrillinopathies. |journal=Hum. Mutat. |volume=20 |issue= 3 |pages= 153-61 |year= 2002 |pmid= 12203987 |doi= 10.1002/humu.10113 }}
*{{cite journal | author=Adès LC, Holman KJ, Brett MS, ''et al.'' |title=Ectopia lentis phenotypes and the FBN1 gene. |journal=Am. J. Med. Genet. A |volume=126 |issue= 3 |pages= 284-9 |year= 2004 |pmid= 15054843 |doi= 10.1002/ajmg.a.20605 }}
*{{cite journal | author=Milewicz DM, Dietz HC, Miller DC |title=Treatment of aortic disease in patients with Marfan syndrome. |journal=Circulation |volume=111 |issue= 11 |pages= e150-7 |year= 2005 |pmid= 15781745 |doi= 10.1161/01.CIR.0000155243.70456.F4 }}
*{{cite journal | author=Boileau C, Jondeau G, Mizuguchi T, Matsumoto N |title=Molecular genetics of Marfan syndrome. |journal=Curr. Opin. Cardiol. |volume=20 |issue= 3 |pages= 194-200 |year= 2005 |pmid= 15861007 |doi= }}
*{{cite journal | author=Whiteman P, Hutchinson S, Handford PA |title=Fibrillin-1 misfolding and disease. |journal=Antioxid. Redox Signal. |volume=8 |issue= 3-4 |pages= 338-46 |year= 2006 |pmid= 16677079 |doi= 10.1089/ars.2006.8.338 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FLT1... {November 1, 2007 3:16:34 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein FLT1 image.jpg {November 1, 2007 3:17:15 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:17:27 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FLT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1flt.
| PDB = {{PDB2|1flt}}, {{PDB2|1qsv}}, {{PDB2|1qsz}}, {{PDB2|1qty}}, {{PDB2|1rv6}}
| Name = Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
| HGNCid = 3763
| Symbol = FLT1
| AltSymbols =; FLT; VEGFR1
| OMIM = 165070
| ECnumber =
| Homologene = 20463
| MGIid = 95558
| GeneAtlas_image1 = PBB_GE_FLT1_222033_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005021 |text = vascular endothelial growth factor receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2321
| Hs_Ensembl = ENSG00000102755
| Hs_RefseqProtein = NP_002010
| Hs_RefseqmRNA = NM_002019
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 27773790
| Hs_GenLoc_end = 27967232
| Hs_Uniprot = P17948
| Mm_EntrezGene = 14254
| Mm_Ensembl = ENSMUSG00000029648
| Mm_RefseqmRNA = NM_010228
| Mm_RefseqProtein = NP_034358
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 147872545
| Mm_GenLoc_end = 148036360
| Mm_Uniprot = Q9CSC8
}}
}}
'''Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)''', also known as '''FLT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Petrova TV, Makinen T, Alitalo K |title=Signaling via vascular endothelial growth factor receptors. |journal=Exp. Cell Res. |volume=253 |issue= 1 |pages= 117-30 |year= 1999 |pmid= 10579917 |doi= 10.1006/excr.1999.4707 }}
*{{cite journal | author=Sato Y, Kanno S, Oda N, ''et al.'' |title=Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction. |journal=Ann. N. Y. Acad. Sci. |volume=902 |issue= |pages= 201-5; discussion 205-7 |year= 2000 |pmid= 10865839 |doi= }}
*{{cite journal | author=Boyd AW, Lackmann M |title=Signals from Eph and ephrin proteins: a developmental tool kit. |journal=Sci. STKE |volume=2001 |issue= 112 |pages= RE20 |year= 2002 |pmid= 11741094 |doi= 10.1126/stke.2001.112.re20 }}
*{{cite journal | author=Luttun A, Tjwa M, Carmeliet P |title=Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. |journal=Ann. N. Y. Acad. Sci. |volume=979 |issue= |pages= 80-93 |year= 2003 |pmid= 12543719 |doi= }}
*{{cite journal | author=Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA |title=Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. |journal=Pediatr. Res. |volume=57 |issue= 5 Pt 2 |pages= 1R-7R |year= 2005 |pmid= 15817508 |doi= 10.1203/01.PDR.0000159567.85157.B7 }}
*{{cite journal | author=Shibuya M |title=Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. |journal=Angiogenesis |volume=9 |issue= 4 |pages= 225-30; discussion 231 |year= 2007 |pmid= 17109193 |doi= 10.1007/s10456-006-9055-8 }}
*{{cite journal | author=Widmer M, Villar J, Benigni A, ''et al.'' |title=Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review. |journal=Obstetrics and gynecology |volume=109 |issue= 1 |pages= 168-80 |year= 2007 |pmid= 17197602 |doi= 10.1097/01.AOG.0000249609.04831.7c }}
*{{cite journal | author=López-Novoa JM |title=Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 3 |pages= 712-4 |year= 2007 |pmid= 17210583 |doi= 10.1093/ndt/gfl768 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FOS... {November 1, 2007 3:17:27 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 3:18:03 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:18:22 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FOS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a02.
| PDB = {{PDB2|1a02}}, {{PDB2|1fos}}, {{PDB2|1s9k}}
| Name = V-fos FBJ murine osteosarcoma viral oncogene homolog
| HGNCid = 3796
| Symbol = FOS
| AltSymbols =; c-fos
| OMIM = 164810
| ECnumber =
| Homologene = 3844
| MGIid = 95574
| GeneAtlas_image1 = PBB_GE_FOS_209189_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2353
| Hs_Ensembl = ENSG00000170345
| Hs_RefseqProtein = NP_005243
| Hs_RefseqmRNA = NM_005252
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 74815284
| Hs_GenLoc_end = 74818685
| Hs_Uniprot = P01100
| Mm_EntrezGene = 14281
| Mm_Ensembl = ENSMUSG00000021250
| Mm_RefseqmRNA = NM_010234
| Mm_RefseqProtein = NP_034364
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 86363004
| Mm_GenLoc_end = 86366372
| Mm_Uniprot = Q3U463
}}
}}
'''V-fos FBJ murine osteosarcoma viral oncogene homolog''', also known as '''FOS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.<ref>{{cite web | title = Entrez Gene: FOS v-fos FBJ murine osteosarcoma viral oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2353| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Murphy LC, Alkhalaf M, Dotzlaw H, ''et al.'' |title=Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins. |journal=Hum. Reprod. |volume=9 Suppl 1 |issue= |pages= 174-80 |year= 1994 |pmid= 7962462 |doi= }}
*{{cite journal | author=Pompeiano M, Cirelli C, Arrighi P, Tononi G |title=c-Fos expression during wakefulness and sleep. |journal=Neurophysiologie clinique = Clinical neurophysiology |volume=25 |issue= 6 |pages= 329-41 |year= 1997 |pmid= 8904195 |doi= 10.1016/0987-7053(96)84906-9 }}
*{{cite journal | author=Herrera DG, Robertson HA |title=Activation of c-fos in the brain. |journal=Prog. Neurobiol. |volume=50 |issue= 2-3 |pages= 83-107 |year= 1997 |pmid= 8971979 |doi= }}
*{{cite journal | author=Velazquez Torres A, Gariglio Vidal P |title=[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus] |journal=Rev. Invest. Clin. |volume=54 |issue= 3 |pages= 231-42 |year= 2002 |pmid= 12183893 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GH1... {November 1, 2007 3:18:22 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein GH1 image.jpg {November 1, 2007 3:20:27 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:20:46 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GH1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a22.
| PDB = {{PDB2|1a22}}, {{PDB2|1axi}}, {{PDB2|1bp3}}, {{PDB2|1hgu}}, {{PDB2|1huw}}, {{PDB2|1hwg}}, {{PDB2|1hwh}}, {{PDB2|1kf9}}, {{PDB2|3hhr}}
| Name = Growth hormone 1
| HGNCid = 4261
| Symbol = GH1
| AltSymbols =; GH; GH-N; GHN; hGH-N
| OMIM = 139250
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_GH1_205840_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_GH1_206885_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_GH1_206886_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2688
| Hs_Ensembl = ENSG00000189162
| Hs_RefseqProtein = NP_000506
| Hs_RefseqmRNA = NM_000515
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59348294
| Hs_GenLoc_end = 59349886
| Hs_Uniprot = P01241
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Growth hormone 1''', also known as '''GH1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.<ref>{{cite web | title = Entrez Gene: GH1 growth hormone 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2688| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Binder G |title=Isolated growth hormone deficiency and the GH-1 gene: update 2002. |journal=Horm. Res. |volume=58 Suppl 3 |issue= |pages= 2-6 |year= 2003 |pmid= 12435888 |doi= }}
*{{cite journal | author=Waxman DJ, O'Connor C |title=Growth hormone regulation of sex-dependent liver gene expression. |journal=Mol. Endocrinol. |volume=20 |issue= 11 |pages= 2613-29 |year= 2007 |pmid= 16543404 |doi= 10.1210/me.2006-0007 }}
*{{cite journal | author=Cattini PA, Yang X, Jin Y, Detillieux KA |title=Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 145-53 |year= 2006 |pmid= 17047377 |doi= 10.1159/000095522 }}
*{{cite journal | author=Wagner K, Hemminki K, Försti A |title=The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development. |journal=Breast Cancer Res. Treat. |volume=104 |issue= 3 |pages= 233-48 |year= 2007 |pmid= 17082888 |doi= 10.1007/s10549-006-9411-9 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GSTT1... {November 1, 2007 3:20:46 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein GSTT1 image.jpg {November 1, 2007 3:21:20 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 3:21:28 PM PDT}
- CREATED: Created new protein page: GSTT1 {November 1, 2007 3:21:36 PM PDT}
- INFO: Beginning work on HNF4A... {November 1, 2007 3:21:36 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein HNF4A image.jpg {November 1, 2007 3:23:00 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:23:30 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HNF4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m7w.
| PDB = {{PDB2|1m7w}}, {{PDB2|1pzl}}
| Name = Hepatocyte nuclear factor 4, alpha
| HGNCid = 5024
| Symbol = HNF4A
| AltSymbols =; FLJ39654; HNF4; HNF4a7; HNF4a8; HNF4a9; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
| OMIM = 600281
| ECnumber =
| Homologene = 395
| MGIid = 109128
| GeneAtlas_image1 = PBB_GE_HNF4A_216889_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNF4A_208429_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_HNF4A_214832_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3172
| Hs_Ensembl = ENSG00000101076
| Hs_RefseqProtein = NP_000448
| Hs_RefseqmRNA = NM_000457
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 42463324
| Hs_GenLoc_end = 42493444
| Hs_Uniprot = P41235
| Mm_EntrezGene = 15378
| Mm_Ensembl = ENSMUSG00000017950
| Mm_RefseqmRNA = NM_008261
| Mm_RefseqProtein = NP_032287
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 163198277
| Mm_GenLoc_end = 163264348
| Mm_Uniprot = Q3UNX3
}}
}}
'''Hepatocyte nuclear factor 4, alpha''', also known as '''HNF4A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.<ref>{{cite web | title = Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3172| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Winter WE, Nakamura M, House DV |title=Monogenic diabetes mellitus in youth. The MODY syndromes. |journal=Endocrinol. Metab. Clin. North Am. |volume=28 |issue= 4 |pages= 765-85 |year= 2000 |pmid= 10609119 |doi= }}
*{{cite journal | author=Zannis VI, Kan HY, Kritis A, ''et al.'' |title=Transcriptional regulation of the human apolipoprotein genes. |journal=Front. Biosci. |volume=6 |issue= |pages= D456-504 |year= 2001 |pmid= 11229886 |doi= }}
*{{cite journal | author=Gupta RK, Kaestner KH |title=HNF-4alpha: from MODY to late-onset type 2 diabetes. |journal=Trends in molecular medicine |volume=10 |issue= 11 |pages= 521-4 |year= 2005 |pmid= 15519277 |doi= 10.1016/j.molmed.2004.09.004 }}
*{{cite journal | author=Mohlke KL, Boehnke M |title=The role of HNF4A variants in the risk of type 2 diabetes. |journal=Curr. Diab. Rep. |volume=5 |issue= 2 |pages= 149-56 |year= 2005 |pmid= 15794920 |doi= }}
*{{cite journal | author=Love-Gregory L, Permutt MA |title=HNF4A genetic variants: role in diabetes. |journal=Current opinion in clinical nutrition and metabolic care |volume=10 |issue= 4 |pages= 397-402 |year= 2007 |pmid= 17563455 |doi= 10.1097/MCO.0b013e3281e3888d }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPA1A... {November 1, 2007 3:23:30 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein HSPA1A image.jpg {November 1, 2007 3:23:46 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 3:24:05 PM PDT}
- CREATED: Created new protein page: HSPA1A {November 1, 2007 3:24:15 PM PDT}
- INFO: Beginning work on IL13... {November 1, 2007 3:24:15 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL13 image.jpg {November 1, 2007 3:24:51 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:25:33 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IL13_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ga3.
| PDB = {{PDB2|1ga3}}, {{PDB2|1ijz}}, {{PDB2|1ik0}}
| Name = Interleukin 13
| HGNCid = 5973
| Symbol = IL13
| AltSymbols =; ALRH; BHR1; IL-13; MGC116786; MGC116788; MGC116789; P600
| OMIM = 147683
| ECnumber =
| Homologene = 1649
| MGIid = 96541
| GeneAtlas_image1 = PBB_GE_IL13_207844_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005144 |text = interleukin-13 receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3596
| Hs_Ensembl = ENSG00000169194
| Hs_RefseqProtein = NP_002179
| Hs_RefseqmRNA = NM_002188
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 132021764
| Hs_GenLoc_end = 132024701
| Hs_Uniprot = P35225
| Mm_EntrezGene = 16163
| Mm_Ensembl = ENSMUSG00000020383
| Mm_RefseqmRNA = NM_008355
| Mm_RefseqProtein = NP_032381
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 53474747
| Mm_GenLoc_end = 53478125
| Mm_Uniprot = Q5SUZ9
}}
}}
'''Interleukin 13''', also known as '''IL13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.<ref>{{cite web | title = Entrez Gene: IL13 interleukin 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3596| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marone G, Florio G, Petraroli A, de Paulis A |title=Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. |journal=J. Allergy Clin. Immunol. |volume=107 |issue= 1 |pages= 22-30 |year= 2001 |pmid= 11149986 |doi= }}
*{{cite journal | author=Marone G, Florio G, Triggiani M, ''et al.'' |title=Mechanisms of IgE elevation in HIV-1 infection. |journal=Crit. Rev. Immunol. |volume=20 |issue= 6 |pages= 477-96 |year= 2001 |pmid= 11396683 |doi= }}
*{{cite journal | author=Skinnider BF, Kapp U, Mak TW |title=The role of interleukin 13 in classical Hodgkin lymphoma. |journal=Leuk. Lymphoma |volume=43 |issue= 6 |pages= 1203-10 |year= 2003 |pmid= 12152987 |doi= }}
*{{cite journal | author=Izuhara K, Arima K, Yasunaga S |title=IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies. |journal=Current drug targets. Inflammation and allergy |volume=1 |issue= 3 |pages= 263-9 |year= 2003 |pmid= 14561191 |doi= }}
*{{cite journal | author=Dessein A, Kouriba B, Eboumbou C, ''et al.'' |title=Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis. |journal=Immunol. Rev. |volume=201 |issue= |pages= 180-90 |year= 2005 |pmid= 15361241 |doi= 10.1111/j.0105-2896.2004.00195.x }}
*{{cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093-101 |year= 2006 |pmid= 16375755 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAP2K1... {November 1, 2007 3:31:19 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein MAP2K1 image.jpg {November 1, 2007 3:31:55 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 3:32:10 PM PDT}
- CREATED: Created new protein page: MAP2K1 {November 1, 2007 3:32:19 PM PDT}
- INFO: Beginning work on MIF... {November 1, 2007 3:25:33 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein MIF image.jpg {November 1, 2007 3:25:48 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:26:05 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MIF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ca7.
| PDB = {{PDB2|1ca7}}, {{PDB2|1cgq}}, {{PDB2|1gcz}}, {{PDB2|1gd0}}, {{PDB2|1gif}}, {{PDB2|1ljt}}, {{PDB2|1mif}}, {{PDB2|1p1g}}, {{PDB2|2ooh}}, {{PDB2|2oow}}, {{PDB2|2ooz}}
| Name = Macrophage migration inhibitory factor (glycosylation-inhibiting factor)
| HGNCid = 7097
| Symbol = MIF
| AltSymbols =; GIF; GLIF; MMIF
| OMIM = 153620
| ECnumber =
| Homologene = 55655
| MGIid = 96982
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0050178 |text = phenylpyruvate tautomerase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001516 |text = prostaglandin biosynthetic process}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0043030 |text = regulation of macrophage activation}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4282
| Hs_Ensembl = ENSG00000099964
| Hs_RefseqProtein = NP_002406
| Hs_RefseqmRNA = NM_002415
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 22369647
| Hs_GenLoc_end = 22567417
| Hs_Uniprot = P14174
| Mm_EntrezGene = 17319
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010798
| Mm_RefseqProtein = NP_034928
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Macrophage migration inhibitory factor (glycosylation-inhibiting factor)''', also known as '''MIF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.<ref>{{cite web | title = Entrez Gene: MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4282| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bucala R |title=MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response. |journal=FASEB J. |volume=10 |issue= 14 |pages= 1607-13 |year= 1997 |pmid= 9002552 |doi= }}
*{{cite journal | author=Lolis E, Bucala R |title=Macrophage migration inhibitory factor. |journal=Expert Opin. Ther. Targets |volume=7 |issue= 2 |pages= 153-64 |year= 2006 |pmid= 12667094 |doi= 10.1517/14728222.7.2.153 }}
*{{cite journal | author=Calandra T, Roger T |title=Macrophage migration inhibitory factor: a regulator of innate immunity. |journal=Nat. Rev. Immunol. |volume=3 |issue= 10 |pages= 791-800 |year= 2003 |pmid= 14502271 |doi= 10.1038/nri1200 }}
*{{cite journal | author=Shimizu T |title=Role of macrophage migration inhibitory factor (MIF) in the skin. |journal=J. Dermatol. Sci. |volume=37 |issue= 2 |pages= 65-73 |year= 2005 |pmid= 15659324 |doi= 10.1016/j.jdermsci.2004.08.007 }}
*{{cite journal | author=Larson DF, Horak K |title=Macrophage migration inhibitory factor: controller of systemic inflammation. |journal=Critical care (London, England) |volume=10 |issue= 2 |pages= 138 |year= 2006 |pmid= 16677407 |doi= 10.1186/cc4899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MMP14... {November 1, 2007 3:26:05 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 3:27:38 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 3:27:54 PM PDT}
- CREATED: Created new protein page: MMP14 {November 1, 2007 3:28:02 PM PDT}
- INFO: Beginning work on PDGFRB... {November 1, 2007 3:28:02 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:28:50 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Platelet-derived growth factor receptor, beta polypeptide
| HGNCid = 8804
| Symbol = PDGFRB
| AltSymbols =; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR1
| OMIM = 173410
| ECnumber =
| Homologene = 1960
| MGIid = 97531
| GeneAtlas_image1 = PBB_GE_PDGFRB_202273_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004992 |text = platelet activating factor receptor activity}} {{GNF_GO|id=GO:0005017 |text = platelet-derived growth factor receptor activity}} {{GNF_GO|id=GO:0005021 |text = vascular endothelial growth factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5159
| Hs_Ensembl = ENSG00000113721
| Hs_RefseqProtein = NP_002600
| Hs_RefseqmRNA = NM_002609
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 149473598
| Hs_GenLoc_end = 149515615
| Hs_Uniprot = P09619
| Mm_EntrezGene = 18596
| Mm_Ensembl = ENSMUSG00000024620
| Mm_RefseqmRNA = NM_008809
| Mm_RefseqProtein = NP_032835
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 61170519
| Mm_GenLoc_end = 61210428
| Mm_Uniprot = Q003I5
}}
}}
'''Platelet-derived growth factor receptor, beta polypeptide''', also known as '''PDGFRB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.<ref>{{cite web | title = Entrez Gene: PDGFRB platelet-derived growth factor receptor, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5159| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hart CE, Bowen-Pope DF |title=Platelet-derived growth factor receptor: current views of the two-subunit model. |journal=J. Invest. Dermatol. |volume=94 |issue= 6 Suppl |pages= 53S-57S |year= 1990 |pmid= 2161888 |doi= }}
*{{cite journal | author=Steer EJ, Cross NC |title=Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta. |journal=Acta Haematol. |volume=107 |issue= 2 |pages= 113-22 |year= 2002 |pmid= 11919393 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PGR... {November 1, 2007 3:28:50 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein PGR image.jpg {November 1, 2007 3:29:33 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:29:46 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PGR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a28.
| PDB = {{PDB2|1a28}}, {{PDB2|1e3k}}, {{PDB2|1sqn}}, {{PDB2|1sr7}}, {{PDB2|1zuc}}, {{PDB2|2c7a}}, {{PDB2|2ovh}}, {{PDB2|2ovm}}
| Name = Progesterone receptor
| HGNCid = 8910
| Symbol = PGR
| AltSymbols =; NR3C3; PR
| OMIM = 607311
| ECnumber =
| Homologene = 713
| MGIid = 97567
| GeneAtlas_image1 = PBB_GE_PGR_208305_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001542 |text = ovulation (sensu Mammalia)}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0050678 |text = regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0050847 |text = progesterone receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5241
| Hs_Ensembl = ENSG00000082175
| Hs_RefseqProtein = NP_000917
| Hs_RefseqmRNA = NM_000926
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 100414313
| Hs_GenLoc_end = 100506465
| Hs_Uniprot = P06401
| Mm_EntrezGene = 18667
| Mm_Ensembl = ENSMUSG00000031870
| Mm_RefseqmRNA = NM_008829
| Mm_RefseqProtein = NP_032855
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 8862310
| Mm_GenLoc_end = 8927267
| Mm_Uniprot = Q8BW69
}}
}}
'''Progesterone receptor''', also known as '''PGR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Progesterone receptor, a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. Although PRA and PRB share several structural domains, they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PGR progesterone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5241| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Butnor KJ, Burchette JL, Robboy SJ |title=Progesterone receptor activity in leiomyomatosis peritonealis disseminata. |journal=Int. J. Gynecol. Pathol. |volume=18 |issue= 3 |pages= 259-64 |year= 2002 |pmid= 12090595 |doi= }}
*{{cite journal | author=Leonhardt SA, Boonyaratanakornkit V, Edwards DP |title=Progesterone receptor transcription and non-transcription signaling mechanisms. |journal=Steroids |volume=68 |issue= 10-13 |pages= 761-70 |year= 2004 |pmid= 14667966 |doi= }}
*{{cite journal | author=Conneely OM, Mulac-Jericevic B, Lydon JP |title=Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. |journal=Steroids |volume=68 |issue= 10-13 |pages= 771-8 |year= 2004 |pmid= 14667967 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPIA... {November 1, 2007 3:29:46 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPIA image.jpg {November 1, 2007 3:30:02 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:30:23 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPIA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ak4.
| PDB = {{PDB2|1ak4}}, {{PDB2|1awq}}, {{PDB2|1awr}}, {{PDB2|1aws}}, {{PDB2|1awt}}, {{PDB2|1awu}}, {{PDB2|1awv}}, {{PDB2|1bck}}, {{PDB2|1cwa}}, {{PDB2|1cwb}}, {{PDB2|1cwc}}, {{PDB2|1cwf}}, {{PDB2|1cwh}}, {{PDB2|1cwi}}, {{PDB2|1cwj}}, {{PDB2|1cwk}}, {{PDB2|1cwl}}, {{PDB2|1cwm}}, {{PDB2|1cwo}}, {{PDB2|1fgl}}, {{PDB2|1m63}}, {{PDB2|1m9c}}, {{PDB2|1m9d}}, {{PDB2|1m9e}}, {{PDB2|1m9f}}, {{PDB2|1m9x}}, {{PDB2|1m9y}}, {{PDB2|1mf8}}, {{PDB2|1mik}}, {{PDB2|1nmk}}, {{PDB2|1oca}}, {{PDB2|1rmh}}, {{PDB2|1vbs}}, {{PDB2|1vbt}}, {{PDB2|1w8l}}, {{PDB2|1w8m}}, {{PDB2|1w8v}}, {{PDB2|1ynd}}, {{PDB2|1zkf}}, {{PDB2|2alf}}, {{PDB2|2cpl}}, {{PDB2|2cyh}}, {{PDB2|2rma}}, {{PDB2|2rmb}}, {{PDB2|3cyh}}, {{PDB2|3cys}}, {{PDB2|4cyh}}, {{PDB2|5cyh}}
| Name = Peptidylprolyl isomerase A (cyclophilin A)
| HGNCid = 9253
| Symbol = PPIA
| AltSymbols =; CYPA; CYPH; MGC117158; MGC12404; MGC23397
| OMIM = 123840
| ECnumber =
| Homologene = 81388
| MGIid = 3648545
| Function = {{GNF_GO|id=GO:0003755 |text = peptidyl-prolyl cis-trans isomerase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0042277 |text = peptide binding}} {{GNF_GO|id=GO:0046790 |text = virion binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0045069 |text = regulation of viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5478
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001008741
| Hs_RefseqmRNA = NM_001008741
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 668548
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001002180
| Mm_RefseqProtein = XP_001002180
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Peptidylprolyl isomerase A (cyclophilin A)''', also known as '''PPIA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.<ref>{{cite web | title = Entrez Gene: PPIA peptidylprolyl isomerase A (cyclophilin A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5478| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Franke EK, Luban J |title=Cyclophilin and gag in HIV-1 replication and pathogenesis. |journal=Adv. Exp. Med. Biol. |volume=374 |issue= |pages= 217-28 |year= 1995 |pmid= 7572395 |doi= }}
*{{cite journal | author=Sokolskaja E, Luban J |title=Cyclophilin, TRIM5, and innate immunity to HIV-1. |journal=Curr. Opin. Microbiol. |volume=9 |issue= 4 |pages= 404-8 |year= 2006 |pmid= 16815734 |doi= 10.1016/j.mib.2006.06.011 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRKCE... {November 1, 2007 3:30:24 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRKCE image.jpg {November 1, 2007 3:31:01 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 3:31:19 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKCE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gmi.
| PDB = {{PDB2|1gmi}}
| Name = Protein kinase C, epsilon
| HGNCid = 9401
| Symbol = PRKCE
| AltSymbols =; MGC125656; MGC125657; PKCE; nPKC-epsilon
| OMIM = 176975
| ECnumber =
| Homologene = 48343
| MGIid = 97599
| GeneAtlas_image1 = PBB_GE_PRKCE_206248_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004699 |text = calcium-independent protein kinase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5581
| Hs_Ensembl = ENSG00000171132
| Hs_RefseqProtein = NP_005391
| Hs_RefseqmRNA = NM_005400
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 45732547
| Hs_GenLoc_end = 46268632
| Hs_Uniprot = Q02156
| Mm_EntrezGene = 18754
| Mm_Ensembl = ENSMUSG00000045038
| Mm_RefseqmRNA = XM_989478
| Mm_RefseqProtein = XP_994572
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 86076111
| Mm_GenLoc_end = 86563725
| Mm_Uniprot = P16054
}}
}}
'''Protein kinase C, epsilon''', also known as '''PRKCE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.<ref>{{cite web | title = Entrez Gene: PRKCE protein kinase C, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5581| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Slater SJ, Ho C, Stubbs CD |title=The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions. |journal=Chem. Phys. Lipids |volume=116 |issue= 1-2 |pages= 75-91 |year= 2003 |pmid= 12093536 |doi= }}
*{{cite journal | author=Aksoy E, Goldman M, Willems F |title=Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 2 |pages= 183-8 |year= 2004 |pmid= 14643884 |doi= }}
*{{cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, ''et al.'' |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141-51 |year= 2004 |pmid= 15078178 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TCF1... {November 1, 2007 3:32:19 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein TCF1 image.jpg {November 1, 2007 3:32:53 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 3:33:08 PM PDT}
- CREATED: Created new protein page: TCF1 {November 1, 2007 3:33:17 PM PDT}
- INFO: Beginning work on YWHAZ... {November 1, 2007 3:33:17 PM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein YWHAZ image.jpg {November 1, 2007 3:35:19 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 3:35:34 PM PDT}
- CREATED: Created new protein page: YWHAZ {November 1, 2007 3:35:42 PM PDT}
end log.
