User:Mr. Ibrahem/Valaciclovir
 | |
| Clinical data | |
|---|---|
| Trade names | Valtrex, Zelitrex, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a695010 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | By mouth |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 55% |
| Protein binding | 13–18% |
| Metabolism | Liver (to aciclovir) |
| Elimination half-life | <30 minutes (valaciclovir); 2.5–3.6 hours (aciclovir) |
| Excretion | Kidney 40–50% (aciclovir), faecal 47% (aciclovir) |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C13H20N6O4 |
| Molar mass | 324.341 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Valaciclovir, also spelled valacyclovir, is an antiviral medication used to treat outbreaks of herpes simplex or herpes zoster (shingles).[2] It is also used to prevent cytomegalovirus following a kidney transplant in high risk cases.[2] It is taken by mouth.[2]
Common side effects include headache and vomiting.[2] Severe side effects may include kidney problems.[2] Use in pregnancy appears to be safe.[2] It is a prodrug, which works after being converted to aciclovir in a person's body.[2]
Valaciclovir was patented in 1987 and came into medical use in 1995.[3][4] It is available as a generic medication.[5] A month supply in the United Kingdom costs the NHS about £3 as of 2019.[5] In the United States the wholesale cost of this amount is about US$2.80.[6] In 2017, it was the 152nd most commonly prescribed medication in the United States, with more than four million prescriptions.[7] [8]
References[edit]
- ^ "Single Drug Information – International Medical Products Price Guide". Retrieved 23 August 2020.
- ^ a b c d e f g "Valacyclovir Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 17 March 2019.
- ^ Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 504. ISBN 9783527607495.
- ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 625–626. ISBN 9780857113382.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- ^ "Valacyclovir - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.