User:Mr. Ibrahem/Trimethobenzamide
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| Clinical data | |
|---|---|
| Trade names | Tigan, Tebamide, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682693 |
| Routes of administration | By mouth, rectal, intramuscular |
| Drug class | Antihistamine[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 60-100% |
| Onset of action | Within 40 min[1] |
| Elimination half-life | 7 to 9 hours (mean) |
| Duration of action | Up to 4 hrs[1] |
| Excretion | Urine (30-50%), faeces |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C21H28N2O5 |
| Molar mass | 388.464 g·mol−1 |
| 3D model (JSmol) | |
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  (what is this?) (verify) | |
Trimethobenzamide, sold under the brand name Tigan among others, is a medication used to treat nausea and vomiting.[1] This includes that due to surgery and gastroenteritis.[1] It is taken by mouth or by injection into a muscle.[1] Onset occurs within 40 minutes and lasts up to 4 hours.[1]
Common side effects include blurry vision, sleepiness, and muscle cramps.[1] Other side effects may include liver problems and allergic reactions.[1] Safety in pregnancy and breastfeeding is unclear.[2] Use in children with viral infections is not recommended due to concerns of Reye syndrome.[3] It is an antihistamine and believed to work by blocking the chemoreceptor trigger zone.[1]
Trimethobenzamide was approved for medical use in the United States in 1974.[1] It is available as a generic medication.[1] In the United States 30 doses cost less than 20 USD as of 2021.[4]
References[edit]
- ^ a b c d e f g h i j k l m n "Trimethobenzamide Monograph for Professionals". Drugs.com. Archived from the original on 21 August 2021. Retrieved 20 September 2021.
- ^ "Trimethobenzamide Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 20 September 2021.
- ^ Learning, Jones & Bartlett (29 June 2010). 2011 Nurse's Drug Handbook. Jones & Bartlett Publishers. p. 1062. ISBN 978-1-4496-5372-9. Archived from the original on 22 September 2021. Retrieved 20 September 2021.
- ^ "Trimethobenzamide Prices and Trimethobenzamide Coupons - GoodRx". GoodRx. Archived from the original on 10 September 2016. Retrieved 20 September 2021.