User:Mr. Ibrahem/Triamcinolone

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Mr. Ibrahem/Triamcinolone
Clinical data
Trade namesKenalog, Nasacort, others
Other names
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
AHFS/Drugs.comTopical: Monograph
Systemic: Monograph
ENT: Monograph
MedlinePlusa601122
License data
Pregnancy
category
  • AU: A
Routes of
administration		Oral, topical, IM, intra-articular, intrasynovial
Legal status
Legal status
Pharmacokinetic data
Protein binding68%
MetabolismLiver
Elimination half-life88 minutes
ExcretionFecal and Kidney
Identifiers
  • (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Chemical and physical data
FormulaC21H27FO6
Molar mass394.439 g·mol−1
3D model (JSmol)
  • O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3O)C)C
  • InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1 checkY
  • Key:GFNANZIMVAIWHM-OBYCQNJPSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others.[2] It is also used to prevent worsening of asthma and COPD.[2] It can be taken in various ways including by mouth, injection into a muscle, and inhalation.[2]

Common side effects with long term use include osteoporosis, cataracts, thrush, and muscle weakness.[2] Serious side effects may include psychosis, increased risk of infections, adrenal suppression, and bronchospasm.[2] Use in pregnancy is generally safe.[4] It works by decreasing inflammation and immune system activity.[2]

Triamcinolone was patented in 1956 and came into medical use in 1958.[5] It is available as a generic medication.[6] In the United States the wholesale cost is about US$0.06 per gram for the cream.[7] In 2017, it was the 103rd most commonly prescribed medication in the United States, with more than seven million prescriptions.[8][9]

References[edit]

  1. ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1172. ISBN 9780857113382.
  2. ^ a b c d e f g "Triamcinolone Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 7 August 2019. Retrieved 3 March 2019.
  3. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2020. Retrieved 5 September 2020.
  4. ^ "Triamcinolone Use During Pregnancy". Drugs.com. Archived from the original on 24 January 2021. Retrieved 3 March 2019.
  5. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 486. ISBN 978-3-527-60749-5. Archived from the original on 2016-12-22. Retrieved 2019-03-01.
  6. ^ Vallerand, April Hazard (2018). Davis's Drug Guide for Nurses. F.A. Davis. p. 365. ISBN 978-0-8036-7000-6. Archived from the original on 2021-08-29. Retrieved 2019-03-09.
  7. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  8. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  9. ^ "Triamcinolone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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