User:Mr. Ibrahem/Trandolapril

Mr. Ibrahem/Trandolapril
Clinical data
Trade names	Mavik, others
AHFS/Drugs.com	Monograph
MedlinePlus	a697010
Routes of; administration	By mouth
Drug class	ACE inhibitor
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	Trandolapril 80%; (independent of concentration); Trandolaprilat 65 to 94%; (concentration-dependent)
Metabolism	Liver
Elimination half-life	6 hours (trandolapril); 10 hours (trandolaprilat)
Excretion	Fecal and Kidney
Identifiers
	IUPAC name (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid;
Chemical and physical data
Formula	C24H34N2O5
Molar mass	430.545 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	119 to 123 °C (246 to 253 °F)
	SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@H]2CCCC[C@H]12)C)CCc3ccccc3;
	InChI InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1 ; Key:VXFJYXUZANRPDJ-WTNASJBWSA-N ;
	(verify)

Trandolapril, sold under the brand name Mavik among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.^[1] It is one of a number of first line agents for high blood pressure.^[1] It is taken by mouth.^[1]

Common side effects include cough, diarrhea, and dizziness.^[1] Other side effects may include high blood potassium, angioedema, kidney problems, low blood pressure, and liver problems.^[1] Use during pregnancy may harm the baby.^[1] It is an ACE inhibitor.^[1]

Trandolapril was patented in 1981, and approved for medical use in 1993.^[2] It is available as a generic medication.^[3] In the United Kingdom 4 weeks of treatment costs the NHS about £2.60.^[3] This amount in the United States costs about 11 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Trandolapril Monograph for Professionals". Drugs.com. Archived from the original on 6 March 2021. Retrieved 8 October 2021.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-01-06.
^ ^a ^b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 185. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Trandolapril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Trandolapril Monograph for Professionals". Drugs.com. Archived from the original on 6 March 2021. Retrieved 8 October 2021.

[Fis2006-2] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-01-06.

[BNF80-3] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 185. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[4] "Trandolapril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 October 2021.

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