User:Mr. Ibrahem/Thiotepa
| |||
| Clinical data | |||
|---|---|---|---|
| Trade names | Tepadina | ||
| AHFS/Drugs.com | Monograph | ||
| MedlinePlus | a682821 | ||
| License data | |||
| Pregnancy category |
| ||
| Routes of administration | Intravenous, intracavitary, intravesical | ||
| Drug class | Alkylating agent[1] | ||
| Legal status | |||
| Legal status | |||
| Pharmacokinetic data | |||
| Metabolism | Liver (CYP2B, CYP3A) | ||
| Elimination half-life | 1.5–4.1 hours | ||
| Excretion | Kidney 6 hours for thiotepa 8 hours for TEPA | ||
| Identifiers | |||
| |||
| Chemical and physical data | |||
| Formula | C6H12N3PS | ||
| Molar mass | 189.22 g·mol−1 | ||
| 3D model (JSmol) | |||
| |||
| |||
  (what is this?) (verify) | |||
Thiotepa, sold under the brand name Tepadina, is a medication primarily used to treat cancer.[2] This includes bladder, breast, ovarian, and lymphoma.[2] Such use; however, is not recommended by Scotland.[3] Other uses include, as an eye drop, for pterygium.[2]
Common side effects include low blood cells, graft-versus-host disease, blood in the urine, and mucosal inflammation.[1] Other side effects may include further cancer and anaphylaxis.[2] Use in pregnancy may harm the baby.[3] It is an alkylating agent and works by giving cells that divide rapidly.[1]
Thiotepa was approved for medical use in the United States in 1959.[2] It was approved in Europe in 2010, though has been used for decades before this.[1] In the United States it costs about 3,600 USD for 100 mg.[4]
References[edit]
- ^ a b c d e f "Tepadina EPAR". European Medicines Agency (EMA). Archived from the original on 6 March 2021. Retrieved 30 April 2021.
- ^ a b c d e f "Thiotepa Monograph for Professionals". Drugs.com. Archived from the original on 13 August 2020. Retrieved 3 October 2021.
- ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 950. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Thiotepa Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 3 October 2021.