User:Mr. Ibrahem/Tetryzoline
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| Clinical data | |
|---|---|
| Trade names | Rohto Relief, Visine Original, others[1] |
| Other names | Tetrahydrozoline[1] |
| AHFS/Drugs.com | Monograph |
| Pharmacokinetic data | |
| Onset of action | Within minutes[1] |
| Duration of action | Up to 8 hrs[1] |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C13H16N2 |
| Molar mass | 200.285 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 117–119 °C (243–246 °F) [2] 256–257 °C (493–495 °F) for HCl-salt[3] |
| Solubility in water | Very soluble in water and ethanol, slightly soluble in chloroform and insoluble in diethylether[3] mg/mL (20 °C) |
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  (what is this?) (verify) | |
Tetryzoline, also known as tetrahydrozoline, is a medication used to improve swelling of the whites of the eyes.[1] It is available alone and in combination as an over-the-counter eye drop.[1] Effects begin within minutes and may last for up to 8 hours.[1] Long term use may worsen the condition.[1]
Common side effects include dilated pupils, blurry vision, and irritation of the eyes.[1] Other side effects may include redness of the eyes, headache, palpitations, and trouble sleeping.[1] It works by causing blood vessels to contract by activation α-adrenergic receptors.[1]
Tetryzoline was patented in 1954 and came into medical use in 1959.[4] In the United States a bottle costs about 10 USD as of 2021.[5] It is sold under many brand names including Visine and Rohto.[1]
References[edit]
- ^ a b c d e f g h i j k l m n "Tetrahydrozoline Monograph for Professionals". Drugs.com. Archived from the original on 22 January 2021. Retrieved 3 October 2021.
- ^ "US 2731471 A - IP.com". ip.com. Archived from the original on 2021-08-29. Retrieved 2018-09-05.
- ^ a b The Merck index. Chapman & Hall Electronic Publishing Division (12th ed.). Whitehouse Station, NJ, United States: Chapman & Hall Electronic Pub. Division. 2000. p. 1453. ISBN 1584881291. OCLC 46987702.
{{cite book}}: CS1 maint: others (link) - ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 552. ISBN 9783527607495. Archived from the original on 2016-12-29. Retrieved 2021-06-09.
- ^ "Tetrahydrozoline ophthalmic Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 15 April 2021. Retrieved 3 October 2021.