User:Mr. Ibrahem/Tegaserod

Mr. Ibrahem/Tegaserod
Clinical data
Trade names	Zelnorm, Zelmac
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
Legal status
Legal status	US: Usage requires authorization from the FDA;
Pharmacokinetic data
Bioavailability	10%
Protein binding	98%
Metabolism	Stomach and liver
Elimination half-life	11 ± 5 hours
Excretion	Fecal and Kidney
Identifiers
	IUPAC name (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide;
Chemical and physical data
Formula	C16H23N5O
Molar mass	301.394 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCNC(=N)NN=Cc1c[nH]c2ccc(OC)cc12;
	InChI InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21)/b20-11+ ; Key:IKBKZGMPCYNSLU-RGVLZGJSSA-N ;
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Tegaserod, sold under the brand name Zelnorm among others, is a medication used to treat irritable bowel syndrome with constipation.^[1] It is taken by mouth.^[1]

Common side effects include headache, abdominal pain, diarrhea, and dizziness.^[1] Other side effects may include heart attacks, stroke, and suicide.^[1] It is a 5-HT₄ activator which stimulates both contraction and increased fluid release by the intestines.^[1]

Tegaserod was approved for medical use in the United States in 2002.^[1] It was removed from the market in 2007 due to concerns related to the heart but than re-allowed in 2019.^[1] In Europe it was refused approval in both 2005 and 2006.^[2] In the United States it costs about 360 USD per month as of 2021.^[3] It was withdrawn from the market due to commercial reasons in 2022.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Tegaserod Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 24 September 2021.
^ "Zelnorm". Archived from the original on 6 October 2018. Retrieved 24 September 2021.
^ "Zelnorm Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 24 September 2021.
^ "Pharmacist's Letter". pharmacist.therapeuticresearch.com. Archived from the original on 8 August 2022. Retrieved 12 January 2023.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Tegaserod Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 24 September 2021.

[EPAR2021-2] "Zelnorm". Archived from the original on 6 October 2018. Retrieved 24 September 2021.

[3] "Zelnorm Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 24 September 2021.

[4] "Pharmacist's Letter". pharmacist.therapeuticresearch.com. Archived from the original on 8 August 2022. Retrieved 12 January 2023.

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