User:Mr. Ibrahem/Sugammadex

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Mr. Ibrahem/Sugammadex
Clinical data
Pronunciationsoo GAM ma dex
Trade namesBridion
Other namesORG-25969
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B2
Routes of
administration		Intravenous
Drug classSelective relaxant binding agent (SRBA)[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)[2]
  • US: ℞-only[3]
  • EU: Rx-only[4]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Onset of action2 to 3 minutes[1]
Chemical and physical data
FormulaC72H112O48S8
Molar mass2002.12 g·mol−1
3D model (JSmol)
  • C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)O)O)C(=O)O
  • InChI=1S/C72H112O48S8/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m1/s1 ☒N
  • Key:WHRODDIHRRDWEW-VTHZAVIASA-N ☒N
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Sugammadex, sold under the brand name Bridion, is a medication used to reverse the neuromuscular blockade of rocuronium and vecuronium.[3] It is used by injection into a vein.[1] Effects generally occur in 2 to 3 minutes.[1]

Common side effects include cough, airway problems as the anesthesia wears off, low blood pressure, and an abnormal heart rate.[4] Other side effects may include anaphylaxis, vomiting, and headache.[1] It is a selective relaxant binding agent (SRBA) which combines with and inactivates certain medications.[1][4]

Sugammadex was approved for medical use in Europe in 2008 and the United States in 2015.[1][4] In the United Kingdom 2,000 mg costs the NHS about £600 as of 2021.[5] This amount in the United States costs about 1,200 USD.[6]

References[edit]

  1. ^ a b c d e f g h "Sugammadex Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 22 January 2021. Retrieved 15 October 2021.
  2. ^ "Bridion 100 mg/ml solution for injection - Summary of Product Characteristics (SmPC)". (emc). 18 March 2021. Archived from the original on 27 June 2021. Retrieved 27 June 2021.
  3. ^ a b c "Bridion- sugammadex injection, solution". DailyMed. 14 December 2018. Archived from the original on 10 June 2020. Retrieved 10 June 2020.
  4. ^ a b c d e "Bridion EPAR". European Medicines Agency (EMA). Archived from the original on 10 June 2020. Retrieved 10 June 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  5. ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1410. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  6. ^ "Bridion Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 15 October 2021.
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