User:Mr. Ibrahem/Solifenacin

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Mr. Ibrahem/Solifenacin
Clinical data
Trade namesVesicare, Vesicare LS
Other namesYM905
AHFS/Drugs.comMonograph
MedlinePlusa605019
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability90%
Protein binding98%
MetabolismCYP3A4
MetabolitesGlucuronide, N-oxide, others
Elimination half-life45 to 68 hours
ExcretionKidney (69.2%) and fecal (22.5%)
Identifiers
  • (3R)-1-Azabicyclo[2 2 2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Chemical and physical data
FormulaC23H26N2O2
Molar mass362.473 g·mol−1
3D model (JSmol)
  • C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5
  • InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1 ☒N
  • Key:FBOUYBDGKBSUES-VXKWHMMOSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Solifenacin, sold as the brand name Vesicare among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO).[2][3] It may help with incontinence, urinary frequency, and urinary urgency.[4] Benefits appear similar to other medications in the class.[5] It is taken by mouth.[2]

Common side effects include dry mouth, constipation, and urinary tract infection.[2][3] Severe side effects may include urinary retention, QT prolongation, hallucinations, glaucoma, and anaphylaxis.[2][4][3] It is unclear if use is safe during pregnancy.[2] It is of the antimuscarinic class and works by decreasing bladder contractions.[2]

Solifenacin was approved for medical use in the United States in 2004.[2][3][6] A month's supply in the United Kingdom costs the NHS about £28 as of 2019.[4] In the United States the wholesale cost of this amount is about US$370.[7] In 2017, it was the 283rd most commonly prescribed medication in the United States, with more than one million prescriptions.[8][9]

References[edit]

  1. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 7 September 2020.
  2. ^ a b c d e f g "Solifenacin Succinate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 2019-04-02. Retrieved 2019-03-17.
  3. ^ a b c d "FDA Approves First Treatment for a Form of Bladder Dysfunction in Pediatric Patients as Young as 2 Years of Age". U.S. Food and Drug Administration (FDA) (Press release). 26 May 2020. Archived from the original on 29 May 2020. Retrieved 26 May 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  4. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 761. ISBN 9780857113382.
  5. ^ "[93] Are claims for newer drugs for overactive bladder warranted?". Therapeutics Initiative. 22 April 2015. Archived from the original on 2 April 2019. Retrieved 17 March 2019.
  6. ^ "Drug Approval Package: VesiCare (Solifenacin Succinate) NDA #021518". U.S. Food and Drug Administration (FDA). Archived from the original on 29 November 2020. Retrieved 26 May 2020.
  7. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  8. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  9. ^ "Solifenacin Succinate - Drug Usage Statistics". ClinCalc. Archived from the original on 4 July 2020. Retrieved 11 April 2020.
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