User:Mr. Ibrahem/Sertraline

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Mr. Ibrahem/Sertraline
Clinical data
Pronunciation/ˈsərtrəˌliːn/
Trade namesZoloft and others[1]
AHFS/Drugs.comMonograph
MedlinePlusa697048
License data
Pregnancy
category
Addiction
liability		None[3]
Routes of
administration		By mouth (tablets and solution)
Drug classSelective serotonin reuptake inhibitor
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability44%
Protein binding98.5%
MetabolismLiver (N-demethylation mainly by CYP2B6)[9]
MetabolitesNorsertraline
Elimination half-life~23–26 h (66 h [less-active[4] metabolite, norsertraline])[5][6][7][8]
ExcretionKidney
Identifiers
  • (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
Chemical and physical data
FormulaC17H17Cl2N
Molar mass306.23 g·mol−1
3D model (JSmol)
  • ClC1=CC=C([C@H]2C3=C([C@H](CC2)NC)C=CC=C3)C=C1Cl
  • InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 checkY
  • Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N checkY
  (verify)

Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.[12] It is used to treat major depressive disorder, obsessive–compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder.[12] Sertraline is taken by mouth.[12]

Common side effects include diarrhea, sexual dysfunction, and troubles with sleep.[12] Serious side effects include an increased risk of suicide in those less than 25 years old and serotonin syndrome.[12] It is unclear whether use during pregnancy or breastfeeding is safe.[13] It should not be used together with MAO inhibitor medication.[12] Sertraline is believed to work by increasing serotonin effects in the brain.[12]

Sertraline was approved for medical use in the United States in 1991 and initially sold by Pfizer.[12] It is on the World Health Organization's List of Essential Medicines as an alternative to fluoxetine.[14] It is available as a generic medication.[12] In the United States, the wholesale cost is about US$1.50 per month as of 2018.[15] In 2016, it was the most commonly prescribed psychiatric medication in the United States,[16] with over 37 million prescriptions.[17] In 2017, it was the 14th most commonly prescribed medication in the United States with over 38 million prescriptions.[18][17]

References[edit]

  1. ^ "Sertraline". Drugs.com. Archived from the original on 9 May 2015. Retrieved 11 May 2015.
  2. ^ a b "Sertraline (Zoloft) Use During Pregnancy". Drugs.com. 4 May 2020. Archived from the original on 20 June 2020. Retrieved 17 May 2020.
  3. ^ Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically Disabled. CRC Press. p. 26. ISBN 9780824744977. Archived from the original on 1 August 2020. Retrieved 8 August 2020.
  4. ^ Sertraline FDA Label Wayback Machine at the Wayback Machine (archived 30 October 2020) Last updated May 2014
  5. ^ Brunton L, Chabner B, Knollman B. (2010) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional. ISBN 9780071769396
  6. ^ Obach RS, Walsky RL, Venkatakrishnan K, Gaman EA, Houston JB, Tremaine LM (January 2006). "The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions". The Journal of Pharmacology and Experimental Therapeutics. 316 (1): 336–48. doi:10.1124/jpet.105.093229. PMID 16192315. S2CID 12975686.
  7. ^ DeVane CL, Liston HL, Markowitz JS (2002). "Clinical pharmacokinetics of sertraline". Clinical Pharmacokinetics. 41 (15): 1247–66. doi:10.2165/00003088-200241150-00002. PMID 12452737. S2CID 28720641.
  8. ^ DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L (February 2004). "Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers". Journal of Clinical Psychopharmacology. 24 (1): 4–10. doi:10.1097/01.jcp.0000104908.75206.26. PMID 14709940. S2CID 25826168.
  9. ^ Cite error: The named reference pmid15547048 was invoked but never defined (see the help page).
  10. ^ "SERTRALINE oral - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 24 August 2020.
  11. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 9 September 2020.
  12. ^ a b c d e f g h i "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 18 March 2019. Retrieved 8 January 2018.
  13. ^ "Sertraline (Zoloft) Use During Pregnancy". Drugs.com. Archived from the original on 20 June 2020. Retrieved 7 January 2018.
  14. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  15. ^ "NADAC as of 2018-01-03". Centers for Medicare and Medicaid Services. Archived from the original on 24 June 2019. Retrieved 7 January 2018.
  16. ^ Grohol, John M. (12 October 2017). "Top 25 Psychiatric Medications for 2016". Psych Central. Archived from the original on 20 September 2020. Retrieved October 22, 2018.
  17. ^ a b "Sertraline Hydrochloride - Drug Usage Statistics". ClinCalc. 23 December 2019. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
  18. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
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