User:Mr. Ibrahem/Piroxicam
Clinical data | |
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Pronunciation | /paɪˈrɒksɪˌkæm/ |
Trade names | Feldene, others[1] |
Other names | Piroksikam, piroxikam |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684045 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 99%[3] |
Metabolism | Liver-mediated hydroxylation and glucuronidation[3] |
Elimination half-life | 50 hours[3] |
Excretion | Urine, faeces |
Identifiers | |
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Chemical and physical data | |
Formula | C15H13N3O4S |
Molar mass | 331.35 g·mol−1 |
3D model (JSmol) | |
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Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation.[4] This includes in condition like arthritis and painful periods.[4] It is taken by mouth or applied to the skin.[4][5]
Common side effects include heartburn, nausea, diarrhea, rash, headache, swelling, and ringing in the ears.[4] Other side effects may include anaphylaxis, kidney problems, gastrointestinal bleeding, heart disease, heart failure, and high blood pressure.[4] Use in the later part of pregnancy may harm the baby.[4] It is in the oxicam family of medications and works by blocking COX-1 and COX-2.[4]
Piroxicam was patented in 1968 and approved for medical use in 1979.[6] It is available as a generic medication.[5] In the United Kingdom a month of medication costs the NHS about £5 as of 2021.[5] In the United States this amount costs about 30 USD.[7] It is marketed under many brand names.[1]
References[edit]
- ^ a b "Piroxicam Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 28 August 2021. Retrieved 28 October 2021.
- ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-08-28. Retrieved 2021-01-28.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ a b c Brayfield, A, ed. (14 January 2014). "Piroxicam". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Archived from the original on 28 August 2021. Retrieved 24 June 2014.
- ^ a b c d e f g h i "Piroxicam Monograph for Professionals". Drugs.com. Archived from the original on 21 October 2021. Retrieved 28 October 2021.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1196. ISBN 978-0857114105.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 519. ISBN 9783527607495. Archived from the original on 2020-07-10. Retrieved 2020-09-06.
- ^ "Piroxicam Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 28 October 2021.