User:Mr. Ibrahem/Papaverine

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Mr. Ibrahem/Papaverine
Clinical data
Pronunciation/pəˈpævəriːn/
Trade namesPavabid, others
AHFS/Drugs.comMonograph
MedlinePlusa682707
Pregnancy
category
  • AU: A
Routes of
administration		By mouth, intravenous, intramuscular, rectal, intracavernosal
Drug classVasodilator[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability80%
Protein binding~90%
MetabolismLiver
Elimination half-life1.5–2 hours
ExcretionKidney
Identifiers
  • 1-(3,4-Dimethoxybenzyl)-7,8-dimethoxyisoquinoline
Chemical and physical data
FormulaC20H21NO4
Molar mass339.391 g·mol−1
3D model (JSmol)
  • COc1ccc(cc1OC)Cc2c3cc(c(cc3ccn2)OC)OC
  • InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 checkY
  • Key:XQYZDYMELSJDRZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Papaverine is a medication primarily used to treat arterial spasm and erectile dysfunction (ED).[1] It is not a first line agent for ED.[1] Other uses have include painful periods and gastrointestinal spasms.[1] It is given by mouth or by injection.[1] Onset is relatively rapid and lasts for hours.[1]

Common side effects include nausea, constipation, headache, abdominal pain, flushing, low blood pressure, and priapism.[1] Other side effects may include respiratory arrest, liver problems, abuse, and arrhythmia.[1] Safety in pregnancy is unclear.[2]

Papaverine was first isolated in 1848 from opium.[3] Despite being from opium it contains no opioid activity.[4] In the United States a 60 mg dose costs about 40 USD as of 2021.[5]

References[edit]

  1. ^ a b c d e f g h i j "Papaverine Monograph for Professionals". Drugs.com. Archived from the original on 8 June 2021. Retrieved 26 October 2021.
  2. ^ "DailyMed - PAPAVERINE HYDROCHLORIDE injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
  3. ^ Hanessian, Stephen (18 December 2013). Natural Products in Medicinal Chemistry. John Wiley & Sons. p. 227. ISBN 978-3-527-67655-2. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
  4. ^ Sdrales, Lorraine M.; Miller, Ronald D. (21 May 2012). Miller's Anesthesia Review: Expert Consult - Online and Print. Elsevier Health Sciences. p. 66. ISBN 978-1-4377-2793-7. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
  5. ^ "Papaverine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 31 July 2020. Retrieved 26 October 2021.
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