User:Mr. Ibrahem/Nimesulide
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth, rectal, topical |
| Drug class | NSAIDs |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | >97.5% |
| Metabolism | Liver |
| Elimination half-life | 1.8–4.7h |
| Excretion | Kidney (50%), fecal (29%) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C13H12N2O5S |
| Molar mass | 308.31 g·mol−1 |
| 3D model (JSmol) | |
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Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) used for acute pain and painful periods.[1][3] Use is recommended for less than 15 days.[1] There is no evidence of benefit over other NSAIDs and due to side effects it is considered a second line treatment.[2][1]
Side effects may include liver problems including those that result in the need for a liver transplant or death.[2][1][4] Other side effects may include stomach problems.[1] This issue occurs at a higher rate than other NSAIDs.[2] It works primarily by blocking the enzyme COX-2 that makes prostaglandins.[5]
Nimesulide has been approved for medical use in parts of Europe since 1985.[1] It has never been approved in the United States, United Kingdom, Canada, Australia, New Zealand, or Japan due to safety concerns.[2] Approval has been withdrawn in a number of countries including Spain, Ireland, and Finland.[2]
References[edit]
- ^ a b c d e f g "Nimesulide". European Medicines Agency. 2012. Archived from the original on 22 October 2020. Retrieved 27 October 2020.
- ^ a b c d e f "Nimesulide must be withdrawn worldwide due to serious liver damage". www.ti.ubc.ca. Archived from the original on 8 November 2020. Retrieved 27 October 2020.
- ^ "Nimesulide". Drugs.com. Archived from the original on 12 November 2020. Retrieved 27 October 2020.
- ^ Kwon, J; Kim, S; Yoo, H; Lee, E (2019). "Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis". PloS one. 14 (1): e0209264. doi:10.1371/journal.pone.0209264. PMID 30677025.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Aronson, Jeffrey K. (2016). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Elsevier. p. 738. ISBN 978-0-444-53716-4. Archived from the original on 10 November 2021. Retrieved 27 October 2020.