User:Mr. Ibrahem/Naltrexone/bupropion
 Skeletal structures of bupropion (top) and naltrexone (bottom) | |
| Combination of | |
|---|---|
| Naltrexone | Opioid receptor antagonist |
| Bupropion | Norepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist |
| Clinical data | |
| Trade names | Contrave, Mysimba |
| AHFS/Drugs.com | Monograph |
| Routes of administration | By mouth |
| Legal status | |
| Legal status | |
  (what is this?) (verify) | |
Naltrexone/bupropion, sold under the brand name Contrave among others, is a combination medication used to treat obesity together with diet and exercise.[3] Up to 30% more people loss at least 5% body weight with use.[4] Such use; however, is not recommended in the United Kingdom.[5] It is taken by mouth.[3]
Common side effects include nausea, constipation, dizziness, trouble sleeping, dry mouth, and headache.[3] Other side effects may include suicide, psychosis, seizures, high blood pressure, and liver problems.[3] Use during pregnancy is not recommended.[3] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone antidepressant.[1]
The combination was approved for medical use in the United States in 2014, Europe in 2015, and Canada in 2018.[6][2][7] In the United States it costs 330 USD per month as of 2021 while in Canada it is about 350 CAD as of 2022.[8][4] This amount in the United Kingdom costs about £78.[5]
References[edit]
- ^ a b "Contrave Extended-Release- naltrexone hydrochloride and bupropion hydrochloride tablet, extended release". DailyMed. 26 April 2019. Archived from the original on 4 June 2020. Retrieved 5 August 2020.
- ^ a b "Mysimba EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 5 August 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ a b c d e f g "Bupropion / naltrexone (Contrave) Use During Pregnancy". Drugs.com. Archived from the original on 18 January 2021. Retrieved 11 November 2021.
- ^ a b Ton, Joey (2 May 2022). "#314 Weight to Go: Naltrexone/bupropion for weight loss". CFPCLearn. Archived from the original on 1 July 2023. Retrieved 14 June 2023.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 99. ISBN 978-0857114105.
- ^ "Naltrexone And Bupropion Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 11 November 2021.
- ^ "Regulatory Decision Summary - Contrave - Health Canada". Health Canada. 13 February 2018. Archived from the original on 4 December 2020. Retrieved 5 September 2021.
- ^ "Contrave Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 18 April 2021. Retrieved 11 November 2021.