User:Mr. Ibrahem/Metolazone

From Wikipedia, the free encyclopedia
Not to be confused with Metaxalone, a muscle relaxant.
Mr. Ibrahem/Metolazone
Clinical data
Trade namesZaroxolyn, Zytanix, Metoz, others
AHFS/Drugs.comMonograph
MedlinePlusa682345
Pregnancy
category
  • B
Routes of
administration		By mouth
Drug classDiuretic (thiazide-like)[1]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability~65%
MetabolismKidney (minimal)
Elimination half-life14 hours
ExcretionPrimarily urine
Identifiers
  • 7-chloro-2-methyl-4-oxo-3-o-tolyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
Chemical and physical data
FormulaC16H16ClN3O3S
Molar mass365.83 g·mol−1
3D model (JSmol)
Melting point260 °C (500 °F)
  • O=S(=O)(c3c(Cl)cc2c(C(=O)N(c1ccccc1C)C(N2)C)c3)N
  • InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) checkY
  • Key:AQCHWTWZEMGIFD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Metolazone, sold under the brand name Zaroxolyn among others, is a medication used to treat fluid retention and high blood pressure.[2] It may be used for fluid retention in heart failure or kidney disease.[1] It is taken by mouth.[2] Increased urine output may occur within an hour.[1]

Common side effects include low potassium, low sodium, gout, high blood sugar, and abdominal bloating.[1] Other side effects include high calcium, kidney problems, allergic reactions, and low blood pressure with standing.[1] It may be used in pregnancy.[1] It is a diuretic of the thiazide-like type.[1] It works by increasing sodium and water loss in the urine.[1]

Metolazone was patented in 1966 and approved for medical use in 1974.[3] In the United States 100 tablets of 5 mg costs about 80 USD as of 2021.[4] In Canada this amount costs about 40 CAD.[5]

References[edit]

  1. ^ a b c d e f g h i "Metolazone Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2016. Retrieved 18 November 2021.
  2. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 247. ISBN 978-0857114105.
  3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 457. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2020-09-20.
  4. ^ "Metolazone Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 November 2021.
  5. ^ "Formulary Sixtieth Edition" (PDF). 2011. Archived (PDF) from the original on 5 July 2017. Retrieved 18 November 2021.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Metolazone&oldid=1157367811"