User:Mr. Ibrahem/Meningitis

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Meningitis
Meninges of the central nervous system: dura mater, arachnoid mater, and pia mater.
SpecialtyInfectious disease, neurology
SymptomsFever, headache, neck stiffness[1]
ComplicationsDeafness, epilepsy, hydrocephalus, cognitive deficits[2][3]
CausesViral, bacterial, other[4]
Diagnostic methodLumbar puncture[1]
Differential diagnosisEncephalitis, brain tumor, lupus, Lyme disease, seizures, neuroleptic malignant syndrome,[5] naegleriasis[6]
PreventionVaccination[2]
MedicationAntibiotics, antivirals, steroids[1][7][8]
Frequency8.7 million (2015)[9]
Deaths379,000 (2015)[10]

Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.[2] The most common symptoms are fever, headache, and neck stiffness.[1] Other symptoms include confusion or altered consciousness, vomiting, and an inability to tolerate light or loud noises.[1] Young children often exhibit only nonspecific symptoms, such as irritability, drowsiness, or poor feeding.[1] If a rash is present, it may indicate a particular cause of meningitis; for instance, meningitis caused by meningococcal bacteria may be accompanied by a characteristic rash.[2][3]

The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs.[4] Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency.[2][8] A lumbar puncture, in which a needle is inserted into the spinal canal to collect a sample of cerebrospinal fluid (CSF), can diagnose or exclude meningitis.[1][8]

Some forms of meningitis are preventable by immunization with the meningococcal, mumps, pneumococcal, and Hib vaccines.[2] Giving antibiotics to people with significant exposure to certain types of meningitis may also be useful.[1] The first treatment in acute meningitis consists of promptly giving antibiotics and sometimes antiviral drugs.[1][7] Corticosteroids can also be used to prevent complications from excessive inflammation.[3][8] Meningitis can lead to serious long-term consequences such as deafness, epilepsy, hydrocephalus, or cognitive deficits, especially if not treated quickly.[2][3]

In 2015, meningitis occurred in about 8.7 million people worldwide.[9] This resulted in 379,000 deaths—down from 464,000 deaths in 1990.[10][11] With appropriate treatment the risk of death in bacterial meningitis is less than 15%.[1] Outbreaks of bacterial meningitis occur between December and June each year in an area of sub-Saharan Africa known as the meningitis belt.[12] Smaller outbreaks may also occur in other areas of the world.[12] The word meningitis comes from the Greek μῆνιγξ meninx, "membrane", and the medical suffix -itis, "inflammation".[13][14]

References[edit]

  1. ^ a b c d e f g h i j "Bacterial Meningitis". CDC. 1 April 2014. Archived from the original on 5 March 2016. Retrieved 5 March 2016.
  2. ^ a b c d e f g Sáez-Llorens X, McCracken GH (June 2003). "Bacterial meningitis in children". Lancet. 361 (9375): 2139–48. doi:10.1016/S0140-6736(03)13693-8. PMID 12826449.
  3. ^ a b c d van de Beek D, de Gans J, Tunkel AR, Wijdicks EF (January 2006). "Community-acquired bacterial meningitis in adults". The New England Journal of Medicine. 354 (1): 44–53. doi:10.1056/NEJMra052116. PMID 16394301.
  4. ^ a b Ginsberg L (March 2004). "Difficult and recurrent meningitis" (PDF). Journal of Neurology, Neurosurgery, and Psychiatry. 75 Suppl 1 (90001): i16–21. doi:10.1136/jnnp.2003.034272. PMC 1765649. PMID 14978146. Archived (PDF) from the original on 21 January 2012.
  5. ^ Ferri, Fred F. (2010). Ferri's differential diagnosis : a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders (2nd ed.). Philadelphia: Elsevier/Mosby. p. Chapter M. ISBN 978-0-323-07699-9.
  6. ^ Centers for Disease Control Prevention (CDC) (May 2008). "Primary amebic meningoencephalitis – Arizona, Florida, and Texas, 2007". MMWR. Morbidity and Mortality Weekly Report. 57 (21): 573–27. PMID 18509301. Archived from the original on 2 April 2020. Retrieved 26 July 2020.
  7. ^ a b "Viral Meningitis". CDC. 26 November 2014. Archived from the original on 4 March 2016. Retrieved 5 March 2016.
  8. ^ a b c d Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ (November 2004). "Practice guidelines for the management of bacterial meningitis" (PDF). Clinical Infectious Diseases. 39 (9): 1267–84. doi:10.1086/425368. PMID 15494903. Archived (PDF) from the original on 9 April 2011.
  9. ^ a b GBD 2015 Disease Injury Incidence Prevalence Collaborators (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282. {{cite journal}}: |author1= has generic name (help)CS1 maint: numeric names: authors list (link)
  10. ^ a b GBD 2015 Mortality Causes of Death Collaborators (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281. {{cite journal}}: |author1= has generic name (help)CS1 maint: numeric names: authors list (link)
  11. ^ GBD 2013 Mortality Causes of Death Collaborators (January 2015). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442. Archived from the original on 10 March 2021. Retrieved 26 July 2020. {{cite journal}}: |author1= has generic name (help)CS1 maint: numeric names: authors list (link)
  12. ^ a b "Meningococcal meningitis Fact sheet N°141". WHO. November 2015. Archived from the original on 5 March 2016. Retrieved 5 March 2016.
  13. ^ Mosby's pocket dictionary of medicine, nursing & health professions (6th ed.). St. Louis: Mosby/Elsevier. 2010. p. traumatic meningitis. ISBN 978-0-323-06604-4. Archived from the original on 10 September 2017.
  14. ^ Liddell HG, Scott R (1940). "μῆνιγξ". A Greek-English Lexicon. Oxford: Clarendon Press. Archived from the original on 8 November 2013.