User:Mr. Ibrahem/Loteprednol
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| Clinical data | |
|---|---|
| Trade names | Lotemax, Loterex, others |
| Other names | Loteprednol etabonate, 11β,17α,Dihydroxy-21-oxa-21-chloromethylpregna-1,4-diene-3,20-dione 17α-ethylcarbonate |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Eye drop |
| Drug class | Corticosteroid; glucocorticoid |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | None |
| Protein binding | 95% |
| Metabolism | Ester hydrolysis |
| Metabolites | Δ1-cortienic acid and its etabonate |
| Onset of action | ≤2 hrs (allergic conjunctivitis) |
| Elimination half-life | 2.8 hrs |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C24H31ClO7 |
| Molar mass | 466.96 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 220.5 to 223.5 °C (428.9 to 434.3 °F) |
| Solubility in water | 0.0005 mg/mL (20 °C) |
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Loteprednol, sold under the brand name Lotemax among others, is a corticosteroid used to treat inflammation after eye surgery and allergic conjunctivitis.[1][2] It is used as an eye drop.[1] It should not be used for more than 2 weeks.[1]
Common side effects include dry eye, eye pain, and headaches.[1] Other side effects may include change in taste and facial swelling.[1] It should not be used in people with herpes simplex keratitis.[2]
Loteprednol was patented in 1980 and approved for medical use in 1998.[3] In the United Kingdom 5 ml cost the NHS about £6.[1] In the United States this amount costs about 200 USD.[4] It also comes as a combination medication with tobramycin.[2]
References[edit]
- ^ a b c d e f g h BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1223. ISBN 978-0857114105.
- ^ a b c d "Loteprednol Monograph for Professionals". Drugs.com. Archived from the original on 29 August 2021. Retrieved 24 November 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 488. ISBN 9783527607495. Archived from the original on 2021-03-21. Retrieved 2020-09-20.
- ^ "Loteprednol ophthalmic Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 28 August 2019. Retrieved 24 November 2021.