User:Mr. Ibrahem/Isosorbide mononitrate
Clinical data | |
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Trade names | Monoket, Imdur, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682348 |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
Legal status | |
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Pharmacokinetic data | |
Bioavailability | >95% |
Protein binding | <5% |
Metabolism | Hepatic |
Elimination half-life | 5 hours |
Excretion | Kidney (93%) |
Identifiers | |
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Chemical and physical data | |
Formula | C6H9NO6 |
Molar mass | 191.139 g·mol−1 |
3D model (JSmol) | |
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Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain (angina), heart failure, and esophageal spasms.[3] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers.[3] It is taken by mouth.[3]
Common side effects include headache, low blood pressure with standing, blurry vision, and skin flushing.[3] Serious side effects may include low blood pressure especially if also exposed to PDE5 inhibitors such as sildenafil.[3] Use is not recommended in pregnancy.[4] It is believed to work by relaxing smooth muscle within blood vessels.[3]
It was patented in 1971 and approved for medical use in 1981.[5] It is available as a generic medication.[4] A month's supply in the United Kingdom costs the NHS about one pound sterling per month as of 2019.[4] In the United States the wholesale cost of this amount is about US$4.30.[6] In 2017, it was the 111th most commonly prescribed medication in the United States, with more than six million prescriptions.[7][8]
References[edit]
- ^ a b "Isosorbide mononitrate Use During Pregnancy". Drugs.com. 28 February 2020. Retrieved 14 April 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 6 September 2020.
- ^ a b c d e f "Isosorbide Dinitrate/Mononitrate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 219–220. ISBN 9780857113382.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 454. ISBN 9783527607495.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- ^ "Isosorbide Mononitrate - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.