User:Mr. Ibrahem/Iloprost

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Mr. Ibrahem/Iloprost
Clinical data
Trade namesVentavis, Ilomedine, others
AHFS/Drugs.comMonograph
MedlinePlusa612032
License data
Routes of
administration		Inhaled; Intravenous
Drug classProstacyclin[1]
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityUnclear
Metabolismβ-oxidation
Elimination half-life20–30 minutes
Identifiers
  • 5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-inyl]-bicyclo[3.3.0]octan-3-ylidene}pentanoic acid
Chemical and physical data
FormulaC22H32O4
Molar mass360.494 g·mol−1
3D model (JSmol)
  • CC#CCC(C)[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)O
  • InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1 ☒N
  • Key:HIFJCPQKFCZDDL-ACWOEMLNSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Iloprost, sold under the brand name Ventavis among others, is a medication used to treat pulmonary arterial hypertension (PAH), Raynaud's phenomenon, and chronic limb ischemia.[1][2] It may also be used for frostbite.[3] It may be used by breathing in or injection into a vein.[2]

Common side effects of the inhaled form include headache, flushing, bleeding, chest pain, nausea, cough, and swelling.[4] Other side effects may include low blood pressure and low platelets.[2] Safety in pregnancy is unclear, but benefits may justify its use.[5] It is a manufactured form of prostacyclin which results in blood vessels to dilate.[1][4]

Iloprost was approved for medical use in Europe in 2003 and the United States in 2004.[4][1] It is available as a generic medication.[2] In the United Kingdom 50 micrograms for injection cost the NHS about £60 while 10 micrograms to inhale costs about £10 as of 2021.[2] In the United States this amount of the inhaled form is about 140 USD per dose.[6]

References[edit]

  1. ^ a b c d e "Iloprost Monograph for Professionals". Drugs.com. Archived from the original on 27 April 2021. Retrieved 25 November 2021.
  2. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 200. ISBN 978-0857114105.
  3. ^ a b Kaller, M (October 2017). "BET 2: Treatment of frostbite with iloprost". Emergency medicine journal : EMJ. 34 (10): 689–690. doi:10.1136/emermed-2017-207129.2. PMID 28963381.
  4. ^ a b c d "Ventavis". Archived from the original on 12 November 2020. Retrieved 25 November 2021.
  5. ^ "Iloprost (Ventavis) Use During Pregnancy". Drugs.com. Archived from the original on 30 November 2020. Retrieved 25 November 2021.
  6. ^ "Ventavis Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 April 2021. Retrieved 25 November 2021.
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