User:Mr. Ibrahem/Flurazepam

Mr. Ibrahem/Flurazepam
Clinical data
Trade names	Dalmane, Dalmadorm, Fluzepam, others
Other names	Flurazepam hydrochloride
AHFS/Drugs.com	Monograph
MedlinePlus	a682051
Pregnancy; category	X (Contraindicated);
Routes of; administration	By mouth
Drug class	Benzodiazepine
Legal status
Legal status	CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); US: Schedule IV;
Pharmacokinetic data
Bioavailability	83%
Metabolism	Liver
Metabolites	N-desalkylflurazepam (active metabolite)
Onset of action	Within 45 min
Elimination half-life	2.3 hours; N-desalkylflurazepam: 47–100 hours
Duration of action	Up to 8 hrs
Excretion	Kidney
Identifiers
	IUPAC name 7-Chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;
Chemical and physical data
Formula	C21H23ClFN3O
Molar mass	387.88 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	79.5 °C (175.1 °F)
	SMILES FC1=CC=CC=C1C2=NCC(N(CCN(CC)CC)C3=C2C=C(C=C3)Cl)=O;
	InChI InChI=1S/C21H23ClFN3O/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23/h5-10,13H,3-4,11-12,14H2,1-2H3 ; Key:SAADBVWGJQAEFS-UHFFFAOYSA-N ;
	(verify)

Flurazepam, sold under the brand names Dalmane among others, is a medication used to treat trouble sleeping.^[2] It may be useful for up to 4 weeks.^[1] It is taken by mouth.^[2] Effects begin within 45 minutes and last for up to 8 hours.^[1]

Common side effects include dizziness, poor coordination, and falls.^[1] Other side effects may include addiction, suicide, and agitation.^[1] Use with opioids is generally not recommended.^[1] Use during pregnancy may harm the baby.^[1] It is a benzodiazepine.^[1]

Flurazepam was patented and came into medical use in 1968.^[3] In the United Kingdom 30 tablets costs the NHS less than £10 as of 2021.^[2] This amount in the United States is about 16 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Flurazepam Monograph for Professionals". Drugs.com. Archived from the original on 6 May 2021. Retrieved 14 December 2021.
^ ^a ^b ^c ^d ^e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 508. ISBN 978-0857114105.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 538. ISBN 9783527607495. Archived from the original on 2021-11-01. Retrieved 2021-10-22.
^ "Flurazepam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 October 2016. Retrieved 14 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Flurazepam Monograph for Professionals". Drugs.com. Archived from the original on 6 May 2021. Retrieved 14 December 2021.

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 508. ISBN 978-0857114105.

[Fis2006-3] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 538. ISBN 9783527607495. Archived from the original on 2021-11-01. Retrieved 2021-10-22.

[4] "Flurazepam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 October 2016. Retrieved 14 December 2021.

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