User:Mr. Ibrahem/Dipyridamole

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Mr. Ibrahem/Dipyridamole
Clinical data
Trade namesPersantine, others
AHFS/Drugs.comMonograph
MedlinePlusa682830
Pregnancy
category
  • B
Routes of
administration		By mouth, IV
Legal status
Legal status
Pharmacokinetic data
Bioavailability37–66%[1]
Protein binding~99%
MetabolismLiver (glucuronidation)[2]
Elimination half-lifeα phase: 40 min,
β phase: 10 hours
ExcretionBiliary (95%), urine (negligible)
Identifiers
  • 2,2',2'',2'''-(4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl)tetraethanol
Chemical and physical data
FormulaC24H40N8O4
Molar mass504.636 g·mol−1
3D model (JSmol)
  • OCCN(CCO)C(N=C1N2CCCCC2)=NC3=C1N=C(N(CCO)CCO)N=C3N4CCCCC4
  • InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 checkY
  • Key:IZEKFCXSFNUWAM-UHFFFAOYSA-N checkY
  (verify)

Dipyridamole, sold under the brand name Persantine and others, is a medication used to prevent blood clots and as part of thallium myocardial perfusion imaging.[3] For blood clots prevention it is used together with either aspirin or warfarin.[4] It is taken by mouth or by injected into a vein.[3]

Side effects may include headache, dizziness, flushing, chest pain, gastrointestinal upset, nausea, diarrhea, rash, and itchiness.[4] Other side effects may include liver problems and anaphylaxis.[3] While there is no clear harm with use in pregnancy, such use has not been well studied.[5] It works by dilating blood vessels and decreasing platelet aggregation.[4]

Dipyridamole was approved for medical use in the United States in 1961.[3] It is available as a generic medication.[4] In the United Kingdom 60 pills of 200 mg costs the NHS about £13 as of 2021.[6] This amount in the United States costs about 88 USD.[7]

References[edit]

  1. ^ Nielsen-Kudsk, F; Pedersen, AK (May 1979). "Pharmacokinetics of Dipyridamole". Acta Pharmacologica et Toxicologica. 44 (5): 391–9. doi:10.1111/j.1600-0773.1979.tb02350.x. PMID 474151.
  2. ^ "Aggrenox (aspirin/extended-release dipyridamole) Capsules. Full Prescribing Information" (PDF). Boehringer Ingelheim Pharmaceuticals, Inc. Archived (PDF) from the original on 29 September 2016. Retrieved 1 December 2016.
  3. ^ a b c d e "Dipyridamole Monograph for Professionals". Drugs.com. Archived from the original on 12 May 2021. Retrieved 26 December 2021.
  4. ^ a b c d e "Dipyridamole". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 16 May 2021. Retrieved 26 December 2021.
  5. ^ "Dipyridamole Use During Pregnancy". Drugs.com. Archived from the original on 5 December 2020. Retrieved 26 December 2021.
  6. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 135. ISBN 978-0857114105.
  7. ^ "Dipyridamole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 26 December 2021.
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