User:Mr. Ibrahem/Desloratadine

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Mr. Ibrahem/Desloratadine
Clinical data
Trade namesAerius, Allex, Clarinex, others[1][2]
AHFS/Drugs.comMonograph
MedlinePlusa602002
License data
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth (tablets, solution)
Legal status
Legal status
  • AU: S2 (Pharmacy medicine)
  • CA: OTC
  • UK: POM (Prescription only)
  • US: ℞-only
  • EU: Rx-only
Pharmacokinetic data
BioavailabilityRapidly absorbed
Protein binding83 to 87%
MetabolismUGT2B10, CYP2C8
Metabolites3-Hydroxydesloratadine
Onset of actionWithin 1 hour[3]
Elimination half-life27 hours
Duration of actionUp to 24 hours[3]
Excretion40% as conjugated metabolites into urine
Similar amount into the feces
Identifiers
  • 8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Chemical and physical data
FormulaC19H19ClN2
Molar mass310.83 g·mol−1
3D model (JSmol)
  • Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4
  • InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 checkY
  • Key:JAUOIFJMECXRGI-UHFFFAOYSA-N checkY
  (verify)

Desloratadine, sold under the brand name Clarinex among others, is a medication used to treat allergies such as hay fever and hives.[3] Onset occurs within an hour and lasts for up to 24 hours.[3] It is taken by mouth.[3]

Common side effects include nausea, tiredness, dry mouth, and headache.[3] A lower dose is recommended in those with kidney or liver problems.[3] While there is no clear evidence of harm during pregnancy, such use is generally not recommended.[4][5] It is a second generation antihistamine.[3] It is an active metabolite of loratadine.[3]

Desloratadine was patented in 1984 and came into medical use in 2001.[6] In the United Kingdom it is avaliable as a generic medication and costs the NHS about 1.5 pounds per month.[4] In the United States this amount costs about 17 USD.[7] It is also available with pseudoephedrine.[3]

References[edit]

  1. ^ Murdoch, David; Goa, Karen L.; Keam, Susan J. (April 7, 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders". Drugs. 63 (19): 2051–2077. doi:10.2165/00003495-200363190-00010. PMID 12962522.
  2. ^ "Allex EPAR". European Medicines Agency (EMA). Archived from the original on 2020-12-27. Retrieved 2020-04-05.
  3. ^ a b c d e f g h i j "Desloratadine Monograph for Professionals". Drugs.com. Archived from the original on 2020-08-12. Retrieved 2021-07-16.
  4. ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 294. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  5. ^ "Desloratadine Use During Pregnancy". Drugs.com. Archived from the original on 6 May 2021. Retrieved 16 July 2021.
  6. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495. Archived from the original on 2020-12-27. Retrieved 2020-05-09.
  7. ^ "Desloratadine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 September 2016. Retrieved 16 July 2021.
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