User:Mr. Ibrahem/Demeclocycline

Mr. Ibrahem/Demeclocycline
Clinical data
Trade names	Declomycin
Other names	Demeclocycline hydrochloride, RP-10192
AHFS/Drugs.com	Monograph
MedlinePlus	a682103
Routes of; administration	By mouth
Drug class	Tetracycline antibiotic
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	60–80%
Protein binding	41–50%
Metabolism	Liver
Elimination half-life	10–17 hours
Excretion	Kidney
Identifiers
	IUPAC name (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione;
Chemical and physical data
Formula	C21H21ClN2O8
Molar mass	464.86 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC(=O)C1C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@H]2C(C=1O)N(C)C;
	InChI InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1 ; Key:FMTDIUIBLCQGJB-SEYHBJAFSA-N ;
	(verify)

Demeclocycline, sold under the brand names Declomycin among others, is a tetracycline antibiotic used to treat a number of bacterial infections as well as low sodium due to syndrome of inappropriate ADH (SIADH).^[2] These infections include pneumonia, acne, chlamydia, gonorrhea, and syphilis.^[1] It is taken by my mouth.^[2]

Common side effects include nausea, rash, kidney problems, and allergic reactions.^[1] Other side effects may include diabetes insipidus and a feeling of the world spinning.^[1] Use in pregnancy may harm the baby and use in children under 8 not generally recommended.^[1] Other side effects may include sunburns.^[2]

Demeclocycline has been approved for medical use in the United States since at least 1960.^[1] It is available as a generic medication.^[2] In the United Kingdom 28 tablets of 150 mg costs the NHS about £220 as of 2021.^[2] In the United States this amount is about 70 USD.^[3] It is made from Streptomyces aureofaciens.^[1]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Demeclocycline Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 23 December 2021.
^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 601. ISBN 978-0857114105.
^ "Demeclocycline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 23 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Demeclocycline Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 23 December 2021.

[BNF81-2] ^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 601. ISBN 978-0857114105.

[3] "Demeclocycline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 23 December 2021.

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