User:Mr. Ibrahem/Colesevelam
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| Clinical data | |
|---|---|
| Trade names | Welchol, Cholestagel, Lodalis, others |
| Other names | Colesevelam hydrochloride |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a699050 |
| License data |
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| Routes of administration | By mouth |
| Drug class | Bile acid sequestrant[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | N/A |
| Metabolism | Colesevelam is not absorbed and not metabolised. |
| Elimination half-life | N/A (non-systemic drug) |
| Excretion | By intestines only, colesevelam is non-systemic. |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C31H67Cl3N4O |
| Molar mass | 618.25 g·mol−1 |
  (what is this?) (verify) | |
Colesevelam, sold under the brand name Welchol among others, is a medication used to treat high cholesterol.[1] Statins are generally preferred for this use.[2] Effects on life expectancy are unclear.[1] It may also be used for type 2 diabetes.[2] It is taken by mouth.[1]
Common side effects include constipation, heart burn, and nausea.[1] Other side effects may include pancreatitis, bowel obstruction, and fat soluble vitamin deficiency.[1] While there is no evidence of harm in pregnancy, such use has not been well studied.[3] It is a bile acid sequestrant.[1]
Colesevelam was approved for medical use in the United States in 2000 and Europe in 2004.[1][4] It is available as a generic medication.[5] In the United Kingdom a month of treatment costs the NHS about £115 as of 2021.[6] This amount in the United States costs about 70 USD.[5]
References[edit]
- ^ a b c d e f g h i j k "DailyMed - COLESEVELAM HCL tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 27 March 2021. Retrieved 6 January 2022.
- ^ a b "Colesevelam Monograph for Professionals". Drugs.com. Retrieved 6 January 2022.
- ^ "Colesevelam (Welchol) Use During Pregnancy". Drugs.com. Archived from the original on 17 November 2021. Retrieved 6 January 2022.
- ^ "Cholestagel". Archived from the original on 15 April 2021. Retrieved 6 January 2022.
- ^ a b "Colesevelam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 6 January 2022.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 211. ISBN 978-0857114105.