User:Mr. Ibrahem/Clofarabine

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Mr. Ibrahem/Clofarabine
Clinical data
Trade namesClolar, Evoltra, others
AHFS/Drugs.comMonograph
MedlinePlusa607012
License data
Routes of
administration		Intravenous
Drug classAntimetabolite[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only[2]
  • EU: Rx-only[1]
  • In general: ℞ (Prescription only)
Identifiers
  • 5-(6-amino-2-chloro-purin-9-yl) -4-fluoro-2- (hydroxymethyl)oxolan-3-ol
Chemical and physical data
FormulaC10H11ClFN5O3
Molar mass303.68 g·mol−1
3D model (JSmol)
  • Clc1nc(c2ncn(c2n1)[C@@H]3O[C@@H]([C@@H](O)[C@@H]3F)CO)N
  • InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1 checkY
  • Key:WDDPHFBMKLOVOX-AYQXTPAHSA-N checkY
  (verify)

Clofarabine, sold under the brand name Clolar and Evoltra, is a medication used to treat acute lymphoblastic leukaemia (ALL).[3] It is used when other treatments stop working.[3] It is given by gradual injection into a vein.[3]

Common side effects include low white blood cells with a fever, anxiety, headache, flushing, nausea, diarrhea, itchiness, and tiredness.[1] Other side effects may include bone marrow suppression and tumor lysis syndrome.[3] Use during pregnancy may harm the baby.[3] It is a antimetabolite, specifically an analogue of adenine.[1] As such it disrupts DNA polymerase and RNA reductase preventing the making of new DNA and RNA.[1]

Clofarabine was approved for medical use in the United States in 2004 and Europe in 2006.[3][1] It is available as a generic medication.[4] In the United Kingdom 20 mg costs the NHS about £1,325 as of 2021.[4] In the United States this amount costs about 650 USD.[5]

References[edit]

  1. ^ a b c d e f g h "Evoltra". Archived from the original on 12 November 2020. Retrieved 5 January 2022.
  2. ^ "Clolar- clofarabine injection". DailyMed. 31 December 2019. Archived from the original on 13 August 2020. Retrieved 27 September 2020.
  3. ^ a b c d e f g "Clofarabine Monograph for Professionals". Drugs.com. Archived from the original on 16 August 2019. Retrieved 5 January 2022.
  4. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 953. ISBN 978-0857114105.
  5. ^ "Clofarabine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 May 2016. Retrieved 5 January 2022.
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