User:Mr. Ibrahem/Clascoterone

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Mr. Ibrahem/Clascoterone
Clinical data
Trade namesWinlevi
Other namesCB-03-01; Breezula; 11-Deoxycortisol 17α-propionate; 17α-(Propionyloxy)-
deoxycorticosterone; 21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate
AHFS/Drugs.comMonograph
License data
Routes of
administration		Topical (cream)
Legal status
Legal status
Identifiers
  • [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
Chemical and physical data
FormulaC24H34O5
Molar mass402.531 g·mol−1
3D model (JSmol)
  • CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)C(=O)CO
  • InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1
  • Key:GPNHMOZDMYNCPO-PDUMRIMRSA-N

Clascoterone, sold under the brand name Winlevi, is a medication used to treat acne in those who are at least 12 years old.[2] It is applied to the skin as a cream.[2]

Common side effects include redness, itchiness, dry skin, and localized swelling.[2] Other side effects may include high potassium.[2] Safety in pregnancy is unclear.[2] It is an androgen receptor inhibitor.[2] There appears to be minimal absorption into the circulation, when applied to skin.[3]

Clascoterone was approved for medical use in the United States in 2020.[2] It is not approved in either the United Kingdom or Europe as of 2022.[4] In the United States a 60 gram tube costs about 480 USD as of 2022.[5]

References[edit]

  1. ^ "Winlevi (clascoterone) cream, for topical use" (PDF). Cassiopea. Archived (PDF) from the original on 18 September 2020. Retrieved 9 September 2020.
  2. ^ a b c d e f g h i "DailyMed - WINLEVI- clascoterone cream". dailymed.nlm.nih.gov. Archived from the original on 28 October 2021. Retrieved 3 November 2022.
  3. ^ Kircik LH (July 2019). "What's new in the management of acne vulgaris". Cutis. 104 (1): 48–52. PMID 31487336. Archived from the original on 2020-10-26. Retrieved 2022-09-09.
  4. ^ "Clascoterone". SPS - Specialist Pharmacy Service. 3 March 2018. Archived from the original on 5 December 2021. Retrieved 3 November 2022.
  5. ^ "Winlevi". GoodRx. Archived from the original on 11 November 2022. Retrieved 3 November 2022.
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