User:Mr. Ibrahem/Cinacalcet

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Mr. Ibrahem/Cinacalcet
Clinical data
Trade namesSensipar, Mimpara
AHFS/Drugs.comMonograph
MedlinePlusa605004
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classCalcimimetic[2]
Legal status
Legal status
  • AU: S4 (Prescription only)[3]
  • UK: POM (Prescription only)[4]
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability20 to 25%
increases if taken with food
Protein binding93 to 97%
MetabolismLiver (CYP3A4-, CYP2D6- and CYP1A2-mediated)
Elimination half-life30 to 40 hours
ExcretionKidney (80%) and fecal (15%)
Identifiers
  • (R)-N-[1-(1-naphthyl)ethyl]-3-
    [3-(trifluoromethyl)phenyl]propan-1-amine
Chemical and physical data
FormulaC22H22F3N
Molar mass357.420 g·mol−1
3D model (JSmol)
  • CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
  • InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1 checkY
  • Key:VDHAWDNDOKGFTD-MRXNPFEDSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat secondary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism.[5][2] In secondary hyperparathyroidism, it is used in those who require dialysis; while in parathyroid carcinoma, it is used to treat high blood calcium.[6] It is taken by mouth with food.[5]

Common side effects include nausea and vomiting.[2] Other side effects may include upper GI bleeding, low calcium, low blood pressure, and adynamic bone disease.[5] It should not be used in people with low blood calcium.[2] Safety in pregnancy is unclear.[7] It is a calcimimetic, meaning that it mimics the action of calcium in the body.[2]

Cinacalcet was approved in the United States and Europe in 2004.[5][2] It is available as a generic medication.[8] In the United States 30 pills of 30 mg costs about 17 USD as of 2022.[8] This amount in the United Kingdom costs the NHS about £114.[6]

References[edit]

  1. ^ a b "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com. 19 July 2019. Archived from the original on 7 December 2019. Retrieved 24 December 2019.
  2. ^ a b c d e f g "Mimpara EPAR". European Medicines Agency (EMA). 22 August 2019. Archived from the original on 24 December 2019. Retrieved 23 December 2019. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  3. ^ "Sensipar Tablets". NPS MedicineWise. 1 May 2018. Archived from the original on 7 December 2019. Retrieved 7 December 2019.
  4. ^ "Mimpara 30 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)". electronic medicines compendium (emc). 8 July 2019. Archived from the original on 7 December 2019. Retrieved 7 December 2019.
  5. ^ a b c d e f "Sensipar- cinacalcet hydrochloride tablet, coated". DailyMed. 5 December 2019. Archived from the original on 25 September 2020. Retrieved 24 December 2019.
  6. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1093. ISBN 978-0857114105.
  7. ^ "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com. Archived from the original on 7 December 2019. Retrieved 5 January 2022.
  8. ^ a b "Cinacalcet Prices and Cinacalcet Coupons - GoodRx". GoodRx. Retrieved 5 January 2022.
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