User:Mr. Ibrahem/Bremelanotide

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Mr. Ibrahem/Bremelanotide
Clinical data
Pronunciation/ˌbrɛmɪˈlænətaɪd/ ⓘ
Trade namesVyleesi
Other namesBremelanotide acetate; PT-141; Rekynda
AHFS/Drugs.comMonograph
MedlinePlusa619054
License data
Routes of
administration		Subcutaneous injection[1]
Drug classActivator of melanocortin receptor[1]
Legal status
Legal status
Pharmacokinetic data
BioavailabilitySCTooltip Subcutaneous injection: ~100%[1]
Protein binding21%[1]
MetabolismHydrolysis of peptide bonds[1]
Elimination half-life2.7 hours[1]
ExcretionUrine: 64.8%
Feces: 22.8%
Identifiers
  • (3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid
Chemical and physical data
FormulaC50H68N14O10
Molar mass1025.182 g·mol−1
3D model (JSmol)
  • O=C(C)N[C@@H](CCCC)C(N[C@@H]1C(N[C@@H](CC2=CNC=N2)C(N[C@H](CC3=CC=CC=C3)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CC4=CNC5C=CC=CC45)C(N[C@@H](CCCCNC(C1)=O)C(O)=O)=O)=O)=O)=O)=O)=O
  • InChI=1S/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 checkY
  • Key:FFHBJDQSGDNCIV-MFVUMRCOSA-N checkY
  (verify)

Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women.[2] Specifically it is used in cases which occurs before menopause and are not due to medical problems, mental health, or problems within the relationship.[1] It is given by an injection under the skin.[2]

Common side effects include nausea, pain at the site of injection, flushing, and headache.[2] It may also temporary increase blood pressure and decrease in heart rate, and darken the gums, face, and breasts.[2] Safety in pregnancy is unclear, with evidence of harm in other animals.[3] It is an activator of the melanocortin receptor.[1]

Bremelanotide was approved for medical use in the United States in 2019.[2] It is not approved in either Europe or the United Kingdom.[4] In the United States its costs about 600 USD per dose as of 2022.[5]

References[edit]

  1. ^ a b c d e f g h "Vyleesi- bremelanotide injection". DailyMed. 10 September 2019. Archived from the original on 29 March 2021. Retrieved 20 November 2019.
  2. ^ a b c d e f g "Bremelanotide Acetate Monograph for Professionals". Drugs.com. Archived from the original on 24 October 2019. Retrieved 24 October 2019.
  3. ^ "Bremelanotide (Vyleesi) Use During Pregnancy". Drugs.com. Archived from the original on 24 October 2020. Retrieved 11 January 2022.
  4. ^ "Bremelanotide". SPS - Specialist Pharmacy Service. 22 September 2015. Archived from the original on 11 January 2022. Retrieved 11 January 2022.
  5. ^ "Vyleesi Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.
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