User:Mr. Ibrahem/Avapritinib

Mr. Ibrahem/Avapritinib
Clinical data
Pronunciation	A va PRI ti nib
Trade names	Ayvakit, Ayvakyt
Other names	BLU-285, BLU285
AHFS/Drugs.com	Monograph
MedlinePlus	a620013
License data	EU EMA: by INN; US DailyMed: Avapritinib; US FDA: Ayvakit;
Routes of; administration	By mouth
Drug class	Tyrosine kinase inhibitor
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name (1S)-1-(4-fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl}pyrimidin5-yl)ethan-1-amine;
Chemical and physical data
Formula	C26H27FN10
Molar mass	498.570 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N;
	InChI InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1; Key:DWYRIWUZIJHQKQ-SANMLTNESA-N;

Avapritinib, sold under the brand name Ayvakit, is a medication used to treat systemic mastocytosis and gastrointestinal stromal tumor (GIST).^[2] In GIST it is used for cases with a platelet-derived growth factor receptor A (PDGFRA) exon 18 mutation.^[2] It is taken by mouth.^[2]

Common side effects nausea, tiredness, low red blood cells, swelling, high bilirubin, diarrhea, and forgetfulness.^[1] Other side effects may include pleural effusion and intracranial bleeding.^[2]^[1] Use in pregnancy may harm the baby.^[2] It is a tyrosine kinase inhibitor that blocks the activity of PDGFRA.^[1]

Avapritinib was approved for medical use in the United States and Europe in 2020.^[2]^[1] In the United Kingdom a month costs the NHS about £26,700 as of 2021.^[3] This amount in the United States costs about 34,200 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g "Ayvakyt EPAR". European Medicines Agency (EMA). 20 July 2020. Archived from the original on 1 November 2020. Retrieved 29 September 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Ayvakit- avapritinib tablet, film coated". DailyMed. 21 January 2020. Archived from the original on 27 September 2020. Retrieved 29 September 2020.
^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1013. ISBN 978-0857114105.
^ "Avapritinib Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 January 2022.

[EPAR2022-1] ^ ^a ^b ^c ^d ^e ^f ^g "Ayvakyt EPAR". European Medicines Agency (EMA). 20 July 2020. Archived from the original on 1 November 2020. Retrieved 29 September 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[PI2022-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Ayvakit- avapritinib tablet, film coated". DailyMed. 21 January 2020. Archived from the original on 27 September 2020. Retrieved 29 September 2020.

[BNF81-3] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1013. ISBN 978-0857114105.

[4] "Avapritinib Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 January 2022.

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