User:Mr. Ibrahem/Avanafil

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Mr. Ibrahem/Avanafil
Avanafil is a PDE5 inhibitor
Clinical data
Trade namesStendra
AHFS/Drugs.comMonograph
MedlinePlusa614010
License data
Routes of
administration		By mouth
Drug classPDE5 inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Onset of actionWithin 15 min[2]
Duration of action2 hr[2]
Identifiers
  • (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
Chemical and physical data
FormulaC23H26ClN7O3
Molar mass483.96 g·mol−1
3D model (JSmol)
  • Clc1c(OC)ccc(c1)CNc3nc(ncc3C(=O)NCc2ncccn2)N4[C@@H](CCC4)CO
  • InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1 checkY
  • Key:WEAJZXNPAWBCOA-INIZCTEOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Avanafil, sold under the brand names Stendra and Spedra, is medication used to treat erectile dysfunction.[1] It is taken by mouth.[3] Effects generally begin within 15 minutes and last for up to 2 hours.[2]

Common side effects include headache, flushing, stuffy nose, and back pain.[1] Other side effects may include priapism, vision loss, and hearing loss.[3] It should not be used with nitrovasodilator.[1] It should also be avoided in people with significant liver or kidney problems.[3] It is a PDE5 inhibitor and works by blocking the phosphodiesterase enzyme, thus increasing levels of cyclic guanosine monophosphate (cGMP).[1]

Avanafil was approved for medical use in the United States in 2012 and Europe in 2013.[3][1] In the United Kingdom 4 pills of 100 mg costs the NHS about £14 as of 2021.[4] This amount in the United States is about 210 USD.[5]

References[edit]

  1. ^ a b c d e f g h i "Spedra". Archived from the original on 11 April 2021. Retrieved 16 January 2022.
  2. ^ a b c d "Avanafil". American Society of Health-System Pharmacists. Archived from the original on 30 November 2020. Retrieved 16 January 2022.
  3. ^ a b c d "DailyMed - STENDRA- avanafil tablet". dailymed.nlm.nih.gov. Archived from the original on 17 April 2021. Retrieved 16 January 2022.
  4. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 859. ISBN 978-0857114105.
  5. ^ "Stendra Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 15 October 2021. Retrieved 16 January 2022.
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