User:Mr. Ibrahem/Anakinra
 | |
| Clinical data | |
|---|---|
| Trade names | Kineret |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a602001 |
| License data | |
| Pregnancy category |
|
| Routes of administration | Subcutaneous |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 95% |
| Metabolism | Predominantly kidney |
| Elimination half-life | 4-6 hrs |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C759H1186N208O232S10 |
| Molar mass | 17257.66 g·mol−1 |
  (what is this?) (verify) | |
Anakinra, sold under the brand name Kineret, is a medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease.[3] It is also used in people with COVID-19 who require oxygen therapy.[3] It is given by injection under the skin.[3]
Common side effects include pain at the site of injection, upper respiratory tract infection, headache, nausea, joint pain, and fever.[4] Other side effects may include anaphylaxis.[4] Safety in pregnancy is unclear.[4] It is a recombinant version of the interleukin 1 receptor antagonist protein which blocks the effects of interleukin 1.[3][4]
Anakinra was approved for medical use in the United States in 2001 and Europe in 2002.[4][3] In the United Kingdom a week of medication costs the NHS about £180 as of 2021.[5] This amount in the United States costs about 1,250 USD.[6]
References[edit]
- ^ "UK Anakinra label". UK Electronic Medicines Compendium. 5 October 2017. Archived from the original on 23 March 2018. Retrieved 23 March 2018.
- ^ "US Anakinra label" (PDF). FDA. May 2016. Archived (PDF) from the original on 17 February 2017. Retrieved 23 March 2018. For label updates see FDA index page for BLA 103950 Archived 2021-03-22 at the Wayback Machine
- ^ a b c d e f g "Kineret". Archived from the original on 21 July 2021. Retrieved 14 January 2022.
- ^ a b c d e f "DailyMed - KINERET- anakinra injection, solution". dailymed.nlm.nih.gov. Archived from the original on 23 July 2021. Retrieved 14 January 2022.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1148. ISBN 978-0857114105.
- ^ "Kineret Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 December 2021. Retrieved 14 January 2022.