User:Mr. Ibrahem/Amoxapine

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Not to be confused with Emoxypine.

Mr. Ibrahem/Amoxapine
Clinical data
Pronunciationa mox' a peen[1]
Trade namesAsendin, others
AHFS/Drugs.comMonograph
MedlinePlusa682202
License data
Routes of
administration		by mouth
Drug classTetracyclic antidepressant[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability>60%[2]
Protein binding90%[3]
MetabolismLiver (cytochrome P450 system)[2]
Elimination half-life8–10 hours (30 hours for chief active metabolite)[3]
ExcretionKidney (60%), feces (18%)[2]
Identifiers
  • 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
Chemical and physical data
FormulaC17H16ClN3O
Molar mass313.79 g·mol−1
3D model (JSmol)
  • Clc2ccc1Oc4c(/N=C(\c1c2)N3CCNCC3)cccc4
  • InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 checkY
  • Key:QWGDMFLQWFTERH-UHFFFAOYSA-N checkY
  (verify)

Amoxapine, sold under the brand name Asendin among others, is a medication used to treat depression.[4] This includes depression with psychosis or anxiety.[4] It is taken by mouth.[4] Effects may take 2 weeks.[4]

Common side effects included sleepiness, dizziness, headache, blurred vision, dry mouth, and tremor.[1] Other side effects may include extrapyramidal symptoms, tardive dyskinesia, suicidal thoughts, heart arrhythmias, and milk production.[1] While safety in pregnancy is unclear, harms have been seen in other animals.[5] It is a tetracyclic antidepressant and is believed to work by blocking norepinephrine transmission.[1]

Amoxapine was approved for medical use in the United States in 1980.[4] It is available as a generic medication.[6] In the United States a month of treatment costs about 50 USD as of 2022.[6]

References[edit]

  1. ^ a b c d e f "Amoxapine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 14 January 2022. Retrieved 14 January 2022.
  2. ^ a b c "Asendin, (amoxapine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 2 December 2013. Retrieved 26 November 2013.
  3. ^ a b Kinney, JL; Evans, RL (September–October 1982). "Evaluation of amoxapine". Clinical Pharmacy. 1 (5): 417–24. PMID 6764165.
  4. ^ a b c d e f "Amoxapine Monograph for Professionals". Drugs.com. Archived from the original on 3 December 2013. Retrieved 14 January 2022.
  5. ^ "Amoxapine (Asendin) Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 14 January 2022.
  6. ^ a b "Amoxapine Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 14 January 2022. Retrieved 14 January 2022.
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