User:Mr. Ibrahem/Amantadine
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| Clinical data | |
|---|---|
| Trade names | Gocovri, Symadine, Symmetrel, others |
| Other names | 1-Adamantylamine |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682064 |
| License data |
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| Pregnancy category |
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| Routes of administration | By mouth |
| Legal status | |
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| Pharmacokinetic data | |
| Bioavailability | 86–90%[1] |
| Protein binding | 67%[1] |
| Metabolism | Minimal (mostly to acetyl metabolites)[1] |
| Elimination half-life | 10–31 hours[1] |
| Excretion | Urine[1] |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C10H17N |
| Molar mass | 151.253 g·mol−1 |
| 3D model (JSmol) | |
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Amantadine, sold under the brand name Gocovri among others, is a medication used to treat movement disorders associated with parkinsonism and antipsychotic medication.[3] Other uses may include post herpetic neuralgia and tiredness from multiple sclerosis.[4] It was used to treat and prevent seasonal influenza type A; however, since resistance developed in 2005 such use is no longer recommended.[3] It is taken by mouth.[3]
Amantadine is generally well tolerated.[5] Common side effects include nausea, lightheadedness, and trouble sleeping.[3] Other side effects include swelling of the legs, dry mouth, constipation, neuroleptic malignant syndrome, thoughs of suicide, and hallucinations.[5] Smaller doses are required in people with kidney problems.[3] Use is not recommended during pregnancy or breastfeeding.[4] How it works in movement disorders is unclear, but is believed to be related to increase dopamine effects.[3]
Amantadine was approved for medical use in the United States in 1968.[3] It is available as a generic medication.[4] In the United Kingdom 56 tablets of 100 mg costs the NHS about 36 pounds in 2020.[4] This amount in the United States costs about 23 USD.[6]
References[edit]
- ^ a b c d e f "Symmetrel (amantadine hydrochloride)" (PDF). TGA eBusiness Services. Novartis Pharmaceuticals Australia Pty Limited. 29 June 2011. Retrieved 24 February 2014.
- ^ "Trilasym 50 mg/ 5 ml Oral Solution - Summary of Product Characteristics (SmPC)". (emc). 24 September 2019. Retrieved 26 March 2020.
- ^ a b c d e f g "Amantadine Hydrochloride Monograph for Professionals". Drugs.com. Retrieved 21 November 2020.
- ^ a b c d BNF 79. London: Pharmaceutical Press. March 2020. p. 429. ISBN 978-0857113658.
- ^ a b Chang, C; Ramphul, K (January 2020). "Amantadine". PMID 29763128.
{{cite journal}}: Cite journal requires|journal=(help) - ^ "Amantadine Prices, Coupons & Savings Tips". GoodRx. Retrieved 21 November 2020.