User:Mr. Ibrahem/Alclometasone

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Mr. Ibrahem/Alclometasone
Clinical data
Trade namesAclovate
Other namesAlclometasone dipropionate[1]
AHFS/Drugs.comMonograph
MedlinePlusa604021
Routes of
administration
Topical
Drug classCorticosteroid[2]
Legal status
Legal status
Pharmacokinetic data
Bioavailability3% systemically (topical)
MetabolismHepatic
Onset of actionEczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days [3]
Identifiers
  • (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-Chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Chemical and physical data
FormulaC22H29ClO5
Molar mass408.92 g·mol−1
3D model (JSmol)
  • C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
  • InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1 checkY
  • Key:FJXOGVLKCZQRDN-PHCHRAKRSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Alclometasone, sold under the brand name Aclovate among others, is a corticosteroid used for certain skin conditions.[2] This includes atopic dermatitis, psoriasis, and allergic contact dermatitis.[2] It is applied to the skin.[2]

Common side effects include redness, irritation, acne, skin thinning, and striae.[2] Other side effects may include Cushing’s syndrome and infection.[2] Safety in pregnancy is unclear.[2] It is of moderate strength.[1]

Alclometasone was approved for medical use in the United States in 1982.[2] It is available as a generic medication.[4] In the United States 15 grams costs about 12 USD as of 2022.[4] In the United Kingdom 50 grams costs the NHS about £13.[1]

References[edit]

  1. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1286. ISBN 978-0857114105.
  2. ^ a b c d e f g h i j "Alclometasone Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 13 January 2022.
  3. ^ "Alclometasone - Professional Patient Advice". Drugs.com. Archived from the original on 28 August 2019. Retrieved 29 December 2017.
  4. ^ a b "Alclometasone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 November 2016. Retrieved 13 January 2022.