User:Mr. Ibrahem/Adapalene
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| Clinical data | |
|---|---|
| Trade names | Differin, Pimpal, Gallet, Adelene, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604001 |
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| Routes of administration | Topical |
| Drug class | Retinoids[1] |
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| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Very low |
| Excretion | Bile |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C28H28O3 |
| Molar mass | 412.529 g·mol−1 |
| 3D model (JSmol) | |
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Adapalene, sold under the brand name Differin among others, is a medication primarily used to treat acne.[2] Other uses may include molluscum contagiosum and actinic keratoses.[1] It is applied to the skin.[2]
Common side effects include redness, skin peeling, dry skin, and itchiness.[2] Other side effects may include sunburns.[2] It may result in less irritation than tazarotene.[1] It should not be used in pregnancy.[3] It is a third-generation retinoid and binds to the retinoic acid receptor (RAR).[1] It is more stable compared to tretinoin and tazarotene when exposed to sunlight.[1]
Adapalene was approved for medical use in the United States in 1996.[2] It is available as a generic medication.[4] In the United Kingdom 45 grams costs the NHS about £16 as of 2021.[3] This amount in the United States is about 45 USD.[4] It also comes mixed with benzoyl peroxide.[3]
References[edit]
- ^ a b c d e Tolaymat, L; Zito, PM (January 2021). "Adapalene". PMID 29494115.
{{cite journal}}: Cite journal requires|journal=(help) - ^ a b c d e f g "Adapalene Monograph for Professionals". Drugs.com. Archived from the original on 31 January 2021. Retrieved 13 January 2022.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1313. ISBN 978-0857114105.
- ^ a b "Adapalene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 27 June 2020. Retrieved 13 January 2022.