User:Mr. Ibrahem/Acebutolol

Mr. Ibrahem/Acebutolol
Clinical data
Trade names	Sectral, Prent, others
AHFS/Drugs.com	Monograph
MedlinePlus	a687003
License data	US FDA: Acebutolol;
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, iv
Drug class	Beta blocker
Legal status
Legal status	UK: POM (Prescription only); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	40% (range 35 to 50%)
Metabolism	Hepatic
Onset of action	Within 90 min
Elimination half-life	3-4 hours (parent drug); 8-13 hours (active metabolite)
Duration of action	Up to 24 hr
Excretion	Kidney: 30%; Biliary: 60%
Identifiers
	IUPAC name (RS)-N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}butanamide;
Chemical and physical data
Formula	C18H28N2O4
Molar mass	336.432 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	121 °C (250 °F)
	SMILES O=C(Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C)CCC;
	InChI InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23) ; Key:GOEMGAFJFRBGGG-UHFFFAOYSA-N ;
	(verify)

Acebutolol, sold under the brand names Sectral among others, is a beta blocker used for the treatment of high blood pressure, heart related chest pain, and heart arrhythmias.^[1] They are not generally the initially recommended medication for high blood pressure.^[1] It is taken by mouth.^[1] Onset is within 90 minutes and may last up to 24 hours.^[1]

Common side effects include tiredness, lightheadedness, shortness of breath, constipation, swelling, and depression.^[1] Other side effects may include sexual dysfunction, heart failure, and liver problems.^[1]^[2] Use is not recommended when breastfeeding.^[1] It works by blocking β1-adrenergic receptors.^[1]

Acebutolol was patented in 1967 and approved for medical use in 1973.^[3] It is available as a generic medication.^[4] In the United Kingdom it costs the NHS about 20£ per month.^[2] In the United States this amount is about 18 USD per month as of 2021.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ "Acebutolol Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 18 July 2021.
^ ^a ^b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 163. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08. Retrieved 2020-09-19.
^ ^a ^b "Acebutolol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 July 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ "Acebutolol Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 18 July 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 163. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[3] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08. Retrieved 2020-09-19.

[GX2021-4] "Acebutolol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 July 2021.

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