User:Mr. Ibrahem/ACAM2000 smallpox vaccine

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Mr. Ibrahem/ACAM2000 smallpox vaccine
Clinical data
Trade namesACAM2000
Other namesSmallpox (Vaccinia) vaccine live[1]
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • Potentially harmful[2]
Routes of
administration		Pricking the skin[1]
Legal status
Legal status

ACAM2000 is a smallpox vaccine to protect against smallpox and mpox (monkeypox).[3] A single dose is generally only used in those at high risk of disease.[3] It is given by pricking the skin of the upper arm several times with a 2-pronged needle which has been dipped in the vaccine.[1] Similar vaccines have been used in all age groups.[2] A booster dose may be given every three to ten years in those with continuing high risk.[3]

Common side effects include reactions at the site it was given, swollen lymph nodes, fever, and tiredness.[2] Other side effects may include myocarditis, pericarditis, encephalitis, and vaccinia.[2] While use in pregnancy may harm the baby, such use may be warranted after exposure to smallpox.[2] It contains live vaccinia virus which can spread to close contacts.[2]

ACAM2000 was approved for medical use in the United States in 2007.[4] By 2008, it replaced Dryvax, the prior vaccine of choice for preventing smallpox.[5] It is manufactured by Emergent Product Development Gaithersburg and made in cell culture.[4][6] In 2008 it costs governments about 5 USD per dose.[7]

References[edit]

  1. ^ a b c "ACAM2000 (Smallpox Vaccine) Questions and Answers". FDA. Center for Biologics Evaluation and Research. 23 March 2018. Archived from the original on 20 May 2022. Retrieved 20 May 2022.
  2. ^ a b c d e f g "Smallpox Vaccine Live Monograph for Professionals". Drugs.com. Archived from the original on 1 June 2022. Retrieved 8 August 2022.
  3. ^ a b c d "Mpox in the U.S." Centers for Disease Control and Prevention. 21 October 2022. Archived from the original on 29 November 2022. Retrieved 4 December 2022.
  4. ^ a b Remington, Jack S.; Wilson, Christopher B.; Nizet, Victor; Klein, Jerome O.; Maldonado, Yvonne (27 August 2010). Infectious Diseases of the Fetus and Newborn E-Book. Elsevier Health Sciences. p. 904. ISBN 978-1-4377-3637-3. Archived from the original on 12 August 2022. Retrieved 8 August 2022.
  5. ^ Saleh, Amr; Qamar, Shahraz; Tekin, Aysun; Singh, Romil; Kashyap, Rahul (July 2021). "Vaccine Development Throughout History". Cureus. 13 (7): e16635. doi:10.7759/cureus.16635. ISSN 2168-8184. PMID 34462676. Archived from the original on 2022-05-21. Retrieved 2022-05-21.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Bonville, Cynthia; Domachowske, Joseph (2021). "28. Smallpox". In Domachowske, Joseph; Suryadevara, Manika (eds.). Vaccines: A Clinical Overview and Practical Guide. Switzerland: Springer. pp. 333–342. ISBN 978-3-030-58416-0. Archived from the original on 2 June 2022. Retrieved 1 June 2022.
  7. ^ Lambert de Rouvroit, Axel; Heegaard, Erik D. (January 2016). "Total costs associated with replicating and non-replicating smallpox vaccines". Global Security: Health, Science and Policy. 1 (1): 3–9. doi:10.1080/23793406.2016.1171944.
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