Talk:Von Hippel–Lindau tumor suppressor

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Function[edit]

"In normal cells in hypoxic conditions, HIF1A is activated with little activation of HIF2A. However, in tumors the balance of HIF1A and HIF2A is tipped towards HIF2A. While HIF1A serves as a pro-apoptotic factor, HIF2A interacts with Cyclin D1. This leads to increased survival due to lower rates of apoptosis and increased proliferation due to the activation of Cyclin D1.[3]"

this is pretty dubious. theres plenty of normal cell types that activate HIF2a at least as strongly as HIF1a. the apoptosis part is fairly cell type specific also i think. this isnt a proper reference either --Soltee (talk) 12:16, 9 November 2011 (UTC)[reply]