Talk:Thioflavin

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Untitled[edit]

The molecular weight is 318.86 of Thioflavin T (Sigma). Jitendra Well, I have a few questions about this compound and its use, maybe writing them here will serve as a book mark for me to come back and answer them, if no one else does first.

Is Thioflavin T in fact a fluorescent dye? The article discusses the blue shift that is observed upon amyloid binding. Does thsi make the emission appear green? Yellow? Blue? What does unbound dye look like? Are images of dyed amyloids obtained by difference or is the location of the amyloid apparent a stained sample? How long does the stuff stick around in an amyloid aggregate? —Preceding unsigned comment added by Weise (talk • contribs) 22:38, 28 September 2010 (UTC)[reply]

Planned update[edit]

I am a biophysicist who uses Thioflavin T to study amyloid-forming proteins. The parts of the article dealing with this application of ThT are quite out-of-date. I plan to update this article over the next couple of days with references to recent findings that show how our understanding of this important dye has evolved. Please let me know if you have comments or objections. Ignoramibus (talk) 20:06, 6 May 2011 (UTC)[reply]

Mention of benzylamine is erroneous[edit]

The following passage is erroneous: "Thioflavin T molecule consists of a benzylamine and a benzothiazole ring connected through a carbon-carbon bond." I think the author who wrote it meant "consists of a para-N,N-dimethylaniline and a benzothiazole..." N,N-dimethylaniline is completely different from benzyl amine. The former molecular fragment has a condensed structural formula of (CH3)2N-C6H4- (consistent with the structure), but the latter has a condensed formula of H2N-CH2-C6H4-. 45.62.183.154 (talk) 17:41, 9 February 2024 (UTC)[reply]