Talk:Sigma receptor

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A receptor doesn't cause effects, its interaction with an ligand does.[edit]

"Sigma receptors may induce hallucinogenic effects and also may be responsible for the paradoxical convulsions sometimes seen in opiate overdose."
Not σ-receptors are inducing these effects, their activation by an agonist ligand does; further, in the article, σ-receptors are defined as "non-opioid", yet the image on the right describes it as "sigma opioid receptors".--84.163.87.66 06:56, 28 April 2007 (UTC)[reply]

How can antidepressive effects be seen in mice?[edit]

Wouldn´t it be better to express is like this: " Antidepressive Effects have been concluded."?---- —Preceding unsigned comment added by 91.96.45.250 (talk) 20:14, 9 June 2010 (UTC)[reply]

Slightly Inaccurate?[edit]

"However, pharmacological testing indicated that the σ-receptors were activated by drugs completely unrelated to the opioids, and their function was unrelated to the function of the opioid receptors. For example, phencyclidine(PCP), and the antipsychotic haloperidol may interact with σ-receptors. Neither phencyclidine nor haloperidol have any appreciable chemical similarity to the opioids."

PCP is a relatively strong mu opiate receptor agonist. It also actually does share some structural similarity to morphine and other opioids like pethidine and fentanyl. So does haloperidol. Maybe a good example would be fluoxetine, diphenhydramine, sertraline, or DHEA. (Although truthfully these all have a lot of structural similarity to active opioids.) Also I think the sigma classification is still being disputed. At some point maybe I will find some good examples of the sigma receptors still being referred to as opioid receptors. Mostly the common parlance is orphan receptor. Anyway, this is all minor. :) Good article. — Preceding unsigned comment added by JasonSims1984 (talk • contribs) 04:42, 21 December 2014 (UTC)[reply]

I've removed the more direct claims of this here, but the classification section is a poorly written mess filled with similar claims. I'd like to rewrite it but I'm having a hard time getting a good citation about the history of sigma receptors and their ligands and prototypical ligands being benzomorphans (or what the first discovered ligand was). The whole section is a mess and really needs to be rewritten. Towelbin (talk) 06:49, 30 March 2021 (UTC)[reply]

Woah[edit]

It honestly took me over three minutes to understand what the lead sentence meant. Can this text be simplified?PNSMurthy (talk) 05:54, 1 August 2020 (UTC)[reply]

Tool compound selective for sigma-2 over sigma-1[edit]

I think a link to SAS-1121 belongs somewhere in here. (Obviously the fact I'm trying to de-orphan that article is one reason for me thinking so.) It's a tool compound that was used in research on the σ_2 receptor. Musiconeologist (talk) 02:21, 7 March 2024 (UTC)[reply]