Talk:Reprogramming

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Wiki Education assignment: Molecular Genetics[edit]

This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 August 2022 and 9 December 2022. Further details are available on the course page. Student editor(s): L!ttleW0lf (article contribs).

— Assignment last updated by L!ttleW0lf (talk) 21:39, 10 September 2022 (UTC)[reply]

Missing info on potential for rejuvenation[edit]

The article seems to miss info on potentials of (research and results of) reprogramming for anti-aging / life extension / healthspan-extension interventions.

Moreover, wouldn't it be good if there was info on some of the mechanisms / recent progress / chronology of achievements in this area here or somewhere else?

There also is this section: Induced pluripotent stem cell#Anti-aging properties. Maybe it should be added there instead (or additionally via transclusion). I may possibly also ask at its talk page about this as well.

For relevant studies to add (probably not all), please go to Timeline of senescence research and ctrl+F for "reprogramming" and "Yamanaka".

These two items were featured in 2023 in science in January:

A team led by David Sinclair shows how DNA breaks are a major driver of epigenetic change, and how the loss of epigenetic information is a cause of aging in mammals. Using a treatment based on Yamanaka factors, they demonstrate an ability to drive aging in both the forward and reverse directions in mice.^[1]^[2]^[3]

In a preprint, another team of researchers reports the use of reprogramming to modestly extend the lifespan in elderly mice. However, if it was also applicable to humans, risks reportedly may include the formation of cancer (5 Jan).^[2]^[4]^[5]

References

^ "Old mice grow young again in study. Can people do the same?". CNN. 13 January 2023. Archived from the original on 13 January 2023. Retrieved 13 January 2023.
^ ^a ^b "Two research teams reverse signs of aging in mice". Science. Archived from the original on 14 February 2023. Retrieved 17 February 2023.
^ Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; Blanchette, Marco; Munding, Elizabeth M.; Bhakta, Mital; Chew, Yap Ching; Guo, Wei; Yang, Xiaojing; Maybury-Lewis, Sun; Tian, Xiao; Ross, Jaime M.; Coppotelli, Giuseppe; Meer, Margarita V.; Rogers-Hammond, Ryan; Vera, Daniel L.; Lu, Yuancheng Ryan; Pippin, Jeffrey W.; Creswell, Michael L.; Dou, Zhixun; Xu, Caiyue; Mitchell, Sarah J.; Das, Abhirup; O’Connell, Brendan L.; Thakur, Sachin; Kane, Alice E.; Su, Qiao; Mohri, Yasuaki; Nishimura, Emi K.; Schaevitz, Laura; Garg, Neha; Balta, Ana-Maria; Rego, Meghan A.; Gregory-Ksander, Meredith; Jakobs, Tatjana C.; Zhong, Lei; Wakimoto, Hiroko; Andari, Jihad El; Grimm, Dirk; Mostoslavsky, Raul; Wagers, Amy J.; Tsubota, Kazuo; Bonasera, Stephen J.; Palmeira, Carlos M.; Seidman, Jonathan G.; Seidman, Christine E.; Wolf, Norman S.; Kreiling, Jill A.; Sedivy, John M.; Murphy, George F.; Green, Richard E.; Garcia, Benjamin A.; Berger, Shelley L.; Oberdoerffer, Philipp; Shankland, Stuart J.; Gladyshev, Vadim N.; Ksander, Bruce R.; Pfenning, Andreas R.; Rajman, Luis A.; Sinclair, David A. (19 January 2023). "Loss of epigenetic information as a cause of mammalian aging". Cell. 186 (2): 305–326.e27. doi:10.1016/j.cell.2022.12.027. ISSN 0092-8674. PMID 36638792.
^ "This biotech startup says mice live longer after genetic reprogramming". MIT Technology Review. Archived from the original on 17 February 2023. Retrieved 17 February 2023.
^ Macip, Carolina Cano; Hasan, Rokib; Hoznek, Victoria; Kim, Jihyun; Metzger, Louis E.; Sethna, Saumil; Davidsohn, Noah (27 January 2023). "Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice": 2023.01.04.522507. doi:10.1101/2023.01.04.522507. S2CID 255478053. Archived from the original on 19 February 2023. Retrieved 17 February 2023. {{cite journal}}: Cite journal requires |journal= (help)

Prototyperspective (talk) 14:44, 5 March 2023 (UTC)[reply]

[1] "Old mice grow young again in study. Can people do the same?". CNN. 13 January 2023. Archived from the original on 13 January 2023. Retrieved 13 January 2023.

[twoteams-2] "Two research teams reverse signs of aging in mice". Science. Archived from the original on 14 February 2023. Retrieved 17 February 2023.

[3] Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; Blanchette, Marco; Munding, Elizabeth M.; Bhakta, Mital; Chew, Yap Ching; Guo, Wei; Yang, Xiaojing; Maybury-Lewis, Sun; Tian, Xiao; Ross, Jaime M.; Coppotelli, Giuseppe; Meer, Margarita V.; Rogers-Hammond, Ryan; Vera, Daniel L.; Lu, Yuancheng Ryan; Pippin, Jeffrey W.; Creswell, Michael L.; Dou, Zhixun; Xu, Caiyue; Mitchell, Sarah J.; Das, Abhirup; O’Connell, Brendan L.; Thakur, Sachin; Kane, Alice E.; Su, Qiao; Mohri, Yasuaki; Nishimura, Emi K.; Schaevitz, Laura; Garg, Neha; Balta, Ana-Maria; Rego, Meghan A.; Gregory-Ksander, Meredith; Jakobs, Tatjana C.; Zhong, Lei; Wakimoto, Hiroko; Andari, Jihad El; Grimm, Dirk; Mostoslavsky, Raul; Wagers, Amy J.; Tsubota, Kazuo; Bonasera, Stephen J.; Palmeira, Carlos M.; Seidman, Jonathan G.; Seidman, Christine E.; Wolf, Norman S.; Kreiling, Jill A.; Sedivy, John M.; Murphy, George F.; Green, Richard E.; Garcia, Benjamin A.; Berger, Shelley L.; Oberdoerffer, Philipp; Shankland, Stuart J.; Gladyshev, Vadim N.; Ksander, Bruce R.; Pfenning, Andreas R.; Rajman, Luis A.; Sinclair, David A. (19 January 2023). "Loss of epigenetic information as a cause of mammalian aging". Cell. 186 (2): 305–326.e27. doi:10.1016/j.cell.2022.12.027. ISSN 0092-8674. PMID 36638792.

[4] "This biotech startup says mice live longer after genetic reprogramming". MIT Technology Review. Archived from the original on 17 February 2023. Retrieved 17 February 2023.

[5] Macip, Carolina Cano; Hasan, Rokib; Hoznek, Victoria; Kim, Jihyun; Metzger, Louis E.; Sethna, Saumil; Davidsohn, Noah (27 January 2023). "Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice": 2023.01.04.522507. doi:10.1101/2023.01.04.522507. S2CID 255478053. Archived from the original on 19 February 2023. Retrieved 17 February 2023. {{cite journal}}: Cite journal requires |journal= (help)

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