Talk:Phosphodiesterase

This is the talk page for discussing improvements to the Phosphodiesterase article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Molecular Biology: MCB / Cell Signaling

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Mid-importance).
	This article is within the scope of the Cell Signaling task force, a task force which is currently considered to be inactive.

Medicine Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Redirect to Phosphodiester bonds ?[edit]

Iiuc, phosphodiesterase normally refers specifically to enzymes that degrade cyclic AMP, and has nothing to do with the bonds between adjacent nucleotides that are the main focus of the redirect article. If it's going to redirect somewhere, it should be to cyclic AMP. But I'm not going to start a redirect war. -- dsws 03:49, 12 July 2005 (UTC)[reply]

Yes, I totally agree with dsws. Phosphodiesterase (PDE) represents a large group of enzymes that degrade the cyclic nucleotides, cyclic AMP and cyclic GMP. PDE can be further grouped into 11 families and I think PDE deserves a page by itself and the re-direction is inappropriate. --Wkong 01:08, 10 December 2005 (UTC)[reply]

I concur. IMO, the redirect to Phosphodiester bonds was inappropriate. I've rewritten the article to a small stub. -- PFHLai 07:22, 10 December 2005 (UTC)[reply]

If you say that there are 11 families of PDEs it would be good to mention that this is only true for mammalian cells.

more generally...[edit]

Technically a phosphodiesterase is any enzyme that breaks a phosphodiester bond. This includes DNAses (including restriction enzymes)and RNAses, clycic nucleotide phosphidesterases, and phospholipases C & D. Cyclic nucleotide PDEs may be the family that comes to most peoples' minds when they think of phosphodiesterases but I think the current description is too narrow. I'm happy to expand the page a bit if there's support for this idea... Roadnottaken 16:15, 21 March 2007 (UTC)[reply]

I agree, and MeSH agrees. Your expansion of the article would be quite welcome. --Arcadian 17:09, 21 March 2007 (UTC)[reply]

I'm a little confused about how to proceed. This article is quite good, only, it refers to cyclic nucleotide phosphodiesterases, rather than phosphodiesterases in general. I'd like to just change the title of this page (and fix pages that link to it) and make a new page that points to all the different types of phosphodiesterases... advice? Roadnottaken 19:44, 30 March 2007 (UTC)[reply]

Insulin sensitive PDE?[edit]

I think it would be good to add a section regarding its role in endocrine controlled metabolism, namely insulin-sensitive PDE which decreases levels of cAMP. — Preceding unsigned comment added by Thetokster (talk • contribs) 09:54, 25 May 2011 (UTC)[reply]

Clinical and molecular genetics[edit]

doi:10.1210/er.2013-1053 Endocr Rev JFW | T@lk 19:47, 31 March 2014 (UTC)[reply]