Talk:Pantothenic acid/GA1

GA Review

Article (edit | visual edit | history) · Article talk (edit | history) · Watch

Reviewer: HaEr48 (talk · contribs) 02:31, 20 June 2020 (UTC)

Reviewing. HaEr48 (talk) 02:31, 20 June 2020 (UTC)

Thank you for taking on this review. Looking forward to working with you. Appears you will also be busy with your GA nominations! David notMD (talk) 08:02, 20 June 2020 (UTC)

Thank you for writing this interesting article. Re my GA nominations, lol I have been waiting for them sitting idle, and now suddenly I have three in review :) I'll manage somehow. As for this article, in general it is in good shape, but I have some feedback especially for clarity and completeness. My feedback is below:

• The anion is called pantothenate: I worry that the relevance/meaning of this statement is lost for general readers, and for people familiar with acids it might be already obvious. Is it possible to explain further, or else remove ?
  • Removed the sentence "The anion is called pantothenate." from the Lede, as it is not elaborated on in the body of the article.David notMD (talk) 21:56, 21 June 2020 (UTC)
• Before we go through the biological role etc. could we add a section about the molecular structure or definition, its chemical properties and functional groups, etc? Is it a single compound, or is it a group of related molecules?
  • Added a Definition section at beginning of the article, incorporating those aspects. David notMD (talk) 21:56, 21 June 2020 (UTC)
• The synthesis of CoA from pantothenic acid is down-regulated by the concentration of CoA and acetyl-Co: Can we have a link for "down-regulated", or use an easier-to-understand way to describe it?
  • Better explanation as separate paragraph. David notMD (talk) 16:07, 26 June 2020 (UTC)
• Is it possible to describe how and where the synthesis of CoA from pantothenic acid happens, or which enzymes/pathways are involved?
  • CoA synthesis information copied from Coenzyme A. David notMD (talk) 16:07, 26 June 2020 (UTC)
• CoA is important in energy metabolism : would a link to metabolism be appropriate here?
  • Biological roles better defined, but Wikilinking to Metabolism would be too vague. David notMD (talk) 19:50, 26 June 2020 (UTC)
• "Pantothenic acid in the form of CoA": Isn't it a COA a distinct compound that is synthesized from p. acid and as opposed to a "form" it?
  • Sentence changed. David notMD (talk) 16:07, 26 June 2020 (UTC)
• Food sources of pantothenic acid include animal-sourced foods: Is it possible to enumerate which animal-sourced foods? Or do all animal foods (including meat, eggs and milk) contain it?
  • All animal-sourced foods, included milk and eggs. Sentence revised to state this and appropriate ref used. David notMD (talk) 17:07, 22 June 2020 (UTC)
• Last statement of #Supplements is unreferenced. Also, it would be interesting to see more explanation why pantothenic acid supplement is a thing if its deficiency is extremely rare. Are there traditional uses of the vitamin that are disproved or not corroborated by science?
  • Added sentence and ref (WebMD)for mention of many conditions for which a supplement benefit has been claimed, but scientific evidence not sufficient. David notMD (talk) 19:37, 22 June 2020 (UTC)
• pantothenic acid deficiency is so rare : is there a quantitative measure of how rare?
  • Ref #9 (ODS) has "Pantothenic acid deficiency is very rare in the United States." but no details and no reference for that statement. Likewise, ref #10 (Present Knowledge...) states "...deficiency of this vitamin in humans is very rare." again, with no details or reference. Descriptions of deficiency specifically of pantothenic acid (in Present Knowledge) are of POWs held by Japan in WWII and in experiments in which deficiency was induced by combining a low PA diet with a PA blocking compound. Changed wording in article to "Very rare." David notMD (talk) 19:18, 22 June 2020 (UTC)
• First para of "Dietary recommendations" is unreferenced.
  • Ref added, it's the DRI ref.
• Within the lumen of the intestine: link "lumen"?
  • Done. David notMD (talk) 17:07, 22 June 2020 (UTC)
• Coenzyme A is hydrolyzed to pantothenic acid, then excreted intact in urine: Maybe add "Waste coenzyme A is hydrolyzed …" or something similar, to clarify that this is a totally different process than the absorption.
  • Excretion sentence revised so no mention of coenzyme A.
• Any description of how deficiency is treated?
  • Deficiency of just B5 is very rare. If diagnosed, would be treated with oral B5. If present, B4 deficiency more likely to be occurring in combination with multiple nutrient deficiencies, so treatment would be with an oral vitamin B complex. (from Present Knowledge ref).
• No dietary requirement for pantothenic acid has been established: Add "for ruminants"? The sentence could be taken to mean in general.
• Done. David notMD (talk) 14:50, 24 June 2020 (UTC)
• History: any idea since when/why it was considered one of the B vitamins?
  • Text and refs added to describe how water soluble vitamins were first called "B vitamin" and later identified as eight different vitamins, with pantothenic acid named B5. David notMD (talk) 11:08, 23 June 2020 (UTC)
    • An editor removed the ref as being not WP:RS. Searching for replacement. David notMD (talk) 14:50, 24 June 2020 (UTC)
      • Existing ref Combs2007 provides a reliable source ref for vitamin history
• Suggest adding page number to books to make it easy for cross referencing, e.g. Voet D, Voet JG, Pratt CW. Also the citation of this books suggest that the original book is cited, but the link is to a student companion book, could you clarify?
  • References for books without page numbers: Voet, Gropper, Combs, Natl Research. Cannot identify page numbers for Voet, so Present Knowledge in Nutrition substituted. Added page numbers for the others. David notMD (talk) 16:07, 24 June 2020 (UTC)

--Thank you. HaEr48 (talk) 23:06, 20 June 2020 (UTC)

HaEr48I believe I have addressed all of this set of requests/queries. David notMD (talk) 20:25, 26 June 2020 (UTC)

@David notMD: Thank you for the updates. I have read the article again and I believe it is ready for GA status. HaEr48 (talk) 16:59, 3 July 2020 (UTC)